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MitoSox Red

a fluorescent probe for mitochondrial superoxide

Networked: 18 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Organophosphorus Compounds: 300
  - MitoSox Red: 18
Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 3-Ring Heterocyclic Compounds
    - Phenanthridines: 3
      - MitoSox Red: 18

Experts

1.	Du, Jiankui: 1 article (12/2021)
2.	Wang, Changnan: 1 article (12/2021)
3.	Yuan, Jihong: 1 article (12/2021)
4.	Burcus, Niculina I: 1 article (12/2021)
5.	Guo, Siqi: 1 article (12/2021)
6.	Jing, Yu: 1 article (12/2021)
7.	Scott, Megan: 1 article (12/2021)
8.	Semenov, Iurii: 1 article (12/2021)
9.	Ammar, Oumaima: 1 article (12/2021)
10.	Giovannelli, Lisa: 1 article (12/2021)

Related Diseases

1.	Asthenozoospermia 06/01/2018 - "The latter, together with the results from MitoSox Red assay, may provide insights into the pathophysiological basis of asthenozoospermia." 06/01/2018 - "The aim of this study was to identify the proteins, and thereby the metabolic pathways, responsible for asthenozoospermia, using 2-DE and MALDI-TOF MS, and correlate the results obtained with those of two mitochondrial tests: JC-1 and MitoSox Red. "
2.	Wounds and Injuries (Trauma) 05/10/2019 - "The cell membrane integrity/amount of mitochondrial ROS was determined by treating the strains with extract/standard in presence of H2O2 and propidium iodide (PI)/MitoSOX Red RESULTS: During the preliminary in-vivo wound healing study, the period for complete re-epithelialization of the wound tissue was reduced significantly (pin the treatment groups as compared to the negative control group. "
3.	Mitochondrial Diseases (Mitochondrial Disease) 01/01/2016 - "In addition, MitoSOX Red, JC-1 and cell viability assay showed that ASC-exo reduces mitochondrial dysfunction and cell apoptosis of in vitro HD model. " 03/01/2019 - "Mitochondrial dysfunctions were analyzed by using JC-1, Mitotracker Green FM, and MitoSOX Red dye. " 01/01/2018 - "TNF-α induced mitochondrial dysfunction with impaired basal, ATP-linked, and maximal respiration, decreased cellular ATP synthesis, and increased mitochondrial superoxide production (measured by MitoSOX red fluorescence), which were rescued by inhibiting HDACs with MPT0E014 (1 μM, a Class I and IIb inhibitor), or MS-275 (1 μM, a Class I inhibitor). "
4.	Sepsis (Septicemia) 12/15/2021 - "The model of sepsis was established by applying the cecal ligation and puncture (CLP) method, and mitochondria from the lung tissue were isolated to assess mitochondrial function, as determined from measuring mitochondrial superoxide production using MitoSOX red mitochondrial superoxide indicator and the membrane potential. "
5.	Hyperoxia 10/15/2017 - "Compared with HUVECs from infants who survived without BPD, HUVECs obtained from infants who developed BPD or died had a lower maximal oxygen consumption rate (mean ± SEM, 107 ± 8 vs. 235 ± 22 pmol/min/30,000 cells; P < 0.001), produced more superoxide after exposure to hyperoxia (mean ± SEM, 89,807 ± 16,616 vs. 162,706 ± 25,321 MitoSOX Red fluorescence units; P < 0.05), and released more hydrogen peroxide into the supernatant after hyperoxia exposure (mean ± SEM, 1,879 ± 278 vs. 842 ± 119 resorufin arbitrary fluorescence units; P < 0.001). "

Related Drugs and Biologics

1.	5,5',6,6'- tetrachloro- 1,1',3,3'- tetraethylbenzimidazolocarbocyanine
2.	Proteins (Proteins, Gene)
3.	Propidium (Propidium Iodide)
4.	Superoxides (Superoxide)
5.	Indicators and Reagents (Reagents)
6.	Reactive Oxygen Species (Oxygen Radicals)
7.	Antioxidants
8.	Caspase 3 (Caspase-3)
9.	Lysosomal-Associated Membrane Protein 1
10.	Green Fluorescent Proteins

Related Therapies and Procedures

1.	Resuscitation
2.	Punctures
3.	Ligation