5,5',6,6'- tetrachloro- 1,1',3,3'- tetraethylbenzimidazolocarbocyanine

structure given in first source

Also Known As:

5,5',6,6'-tetrachloro-1,1',3,3'-tetraethylimidacarbocyanine iodide; JC-1; 1H-Benzimidazolium, 5,6-dichloro-2-(3-(5,6-dichloro-1,3-diethyl-1,3-dihydro-2H-benzimidazol-2-ylidene)-1-propenyl)-1,3-diethyl-

Networked: 194 relevant articles (5 outcomes, 19 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Godugu, Chandraiah: 4 articles (01/2020 - 01/2018)
2.	Shankaraiah, Nagula: 3 articles (01/2021 - 01/2018)
3.	Tokala, Ramya: 3 articles (01/2021 - 01/2018)
4.	Lei, Shaoqing: 3 articles (01/2020 - 03/2016)
5.	Su, Wating: 3 articles (01/2020 - 03/2016)
6.	Xia, Zhengyuan: 3 articles (01/2020 - 03/2016)
7.	Zhang, Wei: 3 articles (01/2020 - 08/2013)
8.	Li, Jing: 2 articles (10/2022 - 01/2019)
9.	Zhang, Lin: 2 articles (01/2022 - 05/2014)
10.	Ben-Shachar, Dorit: 2 articles (01/2021 - 01/2015)

Related Diseases

1.	Mitochondrial Diseases (Mitochondrial Disease) 11/27/2023 - "Mitochondrial dysfunction was assessed by the JC-1 probe and Mito-Tracker probe. " 07/08/2023 - "Moreover, we verified the DEGs related to spindle assembly (such as Naip1, Aspm, Racgap1, Zfp207) by real-time quantitative PCR (RT-qPCR) and checked the mitochondrial dysfunction by JC-1 staining. " 01/01/2022 - "Neuronal death and mitochondrial dysfunction were determined by the LDH assay kit and JC-1 staining. " 01/01/2020 - "Apoptosis was further validated to be induced with mitochondria dysfunction, which indicated with JC-1 labeled loss of mitochondrial membrane potential, reduced activity of SOD, and increased MDA and LDH. " 01/01/2019 - "JC-1 assay was used to detect the mitochondrial dysfunction of the cells. "
2.	Neoplasms (Cancer) 01/01/2020 - "Immunofluorescence, immunoprecipitation, MTT, flow cytometry and JC-1 staining analyses were conducted to study the reversal of MDR that is mediated by P-gp and BCRP in cancer cells. " 08/15/2019 - "OPDEA is quickly internalized via macropinocytosis by various cancer cells and transferred into the mitochondria, which slightly lowers the mitochondrial membrane potential as determined by the JC-1 assay." 08/01/2018 - "The antitumor activity of PTE was examined by using the Cell Counting Kit-8, apoptosis assays, cell cycle analysis, JC-1 mitochondrial membrane potential assay, western blot analysis, and tumor xenograft models. " 01/01/2018 - "Furthermore, we found that J1 strongly induced growth arrest of these cancer cells by modulating the mitochondrial membrane potentials without significant effect on normal MCF-10 cells using JC-1 staining and flow cytometry analysis. " 01/01/2018 - "After four weeks of treatment, cancer growth inhibition, rate and mitochondrial membrane potential were measured with MTT and JC-1 assays, respectively, while ROS were estimated fluorimetrically. "
3.	Hypoxia (Hypoxemia) 11/01/2023 - "JC-1 staining indicated that PB2 reduced the mitochondrial membrane potential of cardiomyocytes under hypoxia. " 01/01/2022 - "JC-1 staining, flow cytometry, and TUNEL staining were presented in hypoxia/reoxygenation (H/R)-stimulated H9C2 cells with TRMT5 deficiency. " 01/01/2020 - "Similarly, CGP53353 could restore hypoxic postconditioning (HPostC) protection against hypoxia reoxygenation- (HR-) induced injury evidenced by decreased LDH release and JC-1 monomeric cells and increased cell viability. " 11/13/2023 - "After establishing a RI/R injury mouse model and a hypoxia/reoxygenation (H/R) cell model, the effects of silenced SOCS3 on injury and mitophagy in the above models were analyzed by ELISA, qRT-PCR, Western blot, pathological sections, CCK-8 assay, flow cytometry and JC-1 assay. " 08/31/2023 - "To clarify the mechanisms of CD44+CD24- cells resistance to hypoxia-induced apoptosis is achieved by inhibiting the activation of endoplasmic reticulum stress (ERS) pathway, silenced CHOP and PERK cell lines of EC9706 cells and overexpressed CHOP and PERK cell lines of CD44+CD24- cells were constructed, the effects of hypoxia on apoptosis, cell cycle, and mitochondrial membrane potential were detected by flow cytometry and JC-1 reagent. "
4.	Necrosis 09/17/2014 - "Necrosis was preceded by a very early mitochondrial damage as indicated by JC-1 fluorescence shift, recorded already after 5 min toxin exposure. " 04/30/2015 - "The μsPEFs-treated group indicated mitochondrial damage and tumor necrosis as shown in JC-1 test, flow cytometry, H&E staining and TEM. " 04/25/2002 - "Overexpression of the anti-apoptotic protein Bcl-2 increased both JC-1 and DCFH-DA fluorescence, which was paralleled by protection against cytokine-induced apoptosis and necrosis. " 11/25/2022 - "By using a tumour necrosis factor-α (TNF-α)-induced HUVECs injury model, cell viability and the expression of intercellular adhesion molecule 1 (ICAM1), matrix metalloproteinase 9 (MMP9), cleave-caspase-3 and cleave-caspase-9, in combination with the results of flow cytometry, JC-1 and Hoechst 33258 staining were investigated to evaluate the anti-inflammatory and anti-apoptotic impact effects of IPTS on HUVECs. " 01/01/2019 - "Cell viability, apoptosis and necrosis, mitochondrial transmembrane potential (MTP) and reactive oxygen species (ROS) were examined by CCK-8, FCM, JC-1 and fluorescent probe, respectively. "
5.	Breast Neoplasms (Breast Cancer) 01/01/2017 - "In silico studies, cell cycle, Annexin-V-FITC/PI, JC-1 mitochondrial assay, ROS analysis were performed to analyse the impact of hit compound 3b on breast cancer cells. " 05/02/2022 - "Moreover, the effect of TIMM8A on breast cancer proliferation and apoptosis was evaluated in vitro by CCK-8 assays, EdU cell proliferation assays, JC-1 mitochondrial membrane potential detection assays and Western blot assays and the in vivo effect was revealed through a patient-derived xenograft mouse model. " 01/01/2020 - "Subsequently, we used Hoechst, Annexin V, JC-1 staining to analyze the inhibition pathway of drugs on breast cancer cells. " 09/01/2006 - "Heat-stress induced effects on mitochondrial transmembrane potentials were analyzed in breast cancer cells, species MX1, using the potential sensor JC-1 (Molecular Probes, Invitrogen, Germany). " 01/01/2022 - "Subsequently, Hoechst staining, annexin V flow cytometry, and JC-1 staining were used to analyze the inhibitory pathway of Ad-VT plus cyclophosphamide on breast cancer cells. "

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5.	Adenosine Triphosphate (ATP)
6.	Oxidopamine (6 Hydroxydopamine)
7.	Cytokines
8.	4,5-dianilinophthalimide
9.	citronellol
10.	Reactive Oxygen Species (Oxygen Radicals)

Related Therapies and Procedures

1.	Aftercare (After-Treatment)
2.	Therapeutics
3.	Lasers (Laser)
4.	Drug Therapy (Chemotherapy)
5.	Critical Care (Surgical Intensive Care)