Indicators and Reagents (Reagents)

Substances used for the detection, identification, analysis, etc. of chemical, biological, or pathologic processes or conditions. Indicators are substances that change in physical appearance, e.g., color, at or approaching the endpoint of a chemical titration, e.g., on the passage between acidity and alkalinity. Reagents are substances used for the detection or determination of another substance by chemical or microscopical means, especially analysis. Types of reagents are precipitants, solvents, oxidizers, reducers, fluxes, and colorimetric reagents. (From Grant & Hackh's Chemical Dictionary, 5th ed, p301, p499)

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Networked: 2917 relevant articles (153 outcomes, 335 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Hewinson, R G: 6 articles (06/2012 - 05/2002)
2.	Epstein, Alan L: 6 articles (11/2011 - 12/2002)
3.	Spagnoli, Giulio C: 5 articles (01/2013 - 11/2006)
4.	Vordermeier, H M: 5 articles (03/2012 - 12/2002)
5.	Reiter, Yoram: 5 articles (01/2012 - 07/2002)
6.	Li, Xiao: 4 articles (09/2015 - 12/2009)
7.	Sewell, Andrew K: 4 articles (09/2015 - 07/2007)
8.	Breyer, Matthew D: 4 articles (09/2015 - 03/2007)
9.	Scholler, Nathalie: 4 articles (07/2015 - 01/2011)
10.	Vieths, Stefan: 4 articles (01/2015 - 06/2003)

Related Diseases

1.	Neoplasms (Cancer) 10/02/2013 - "These reagents show enhanced in vivo properties and broad reactivity resulting in dramatically improved labeling and tumor imaging properties compared to those of previously reported ABPs. " 04/01/2010 - "However, the efficacy of these reagents in cancer patients still needs to be proven in randomized clinical trials. " 12/01/2014 - "These mice will not only provide important insights into the mechanisms underlying the loss of RAI uptake in thyroid tumors but will also serve as preclinical animal models to evaluate the efficacy of candidate reagents to selectively increase RAI uptake in thyroid cancers. " 05/16/2014 - "These reagents were effective in killing GBM cells in vitro and in reducing tumor load in subcutaneous mouse models. " 05/01/1998 - "These reagents will permit improved diagnostics and offer the promise of enhanced therapeutic targets for this cancer. "
2.	Infection 02/01/2004 - "These mAbs may be very useful in distinguishing between BHV-1 and BHV-5 infections since most of the traditional reagents and techniques are unable to do so. " 11/01/1986 - "The practical efficacy of these reagents and procedures is documented by the ability of maternal immunization with anti-idiotope to confer complete protection in neonates from a potentially lethal reovirus type 3 viral infection." 02/01/2009 - "Better understanding of the molecular basis of viral structural genes involved with production should contribute significantly toward the development of improved prophylactic and therapeutic reagents to control the infection. " 06/01/2005 - "Better understanding of the molecular basis of viral pathogenesis should contribute significantly towards the development of improved prophylactic, therapeutic and diagnostic reagents to control infections. " 05/01/1994 - "The acquisition of these mAbs provide reagents which would be very useful in the development of simple immunodiagnostic assays for the diagnosis of V. cholerae O139 infections."
3.	Hypersensitivity (Allergy) 12/01/2009 - "Previous studies have demonstrated insufficient sensitivity of commercially available celeriac extract reagents in the diagnosis of celeriac allergy. " 01/01/2007 - "This study describes the production of new reagents to identify eosinophils (as well as granulocytes) in sheep that will be useful in studying the role of eosinophils in disease pathologies in parasite and allergy models." 06/01/2006 - "Previous studies have demonstrated insufficient sensitivity of commercially available cherry extract reagents in the diagnosis of cherry allergy. " 06/01/2005 - "The aim of this study was to evaluate the clinical availability of the lymphocyte stimulation test (LST) using metal reagents as a method for diagnosing metal allergy. " 01/01/2003 - "The reagents described here provide tools for further study of association with clinical and biochemical phenotypes related to allergy and immunity."
4.	Lymphoma (Lymphomas) 04/01/1986 - "A general application of immunophenotyping of malignant lymphomas in clinical hematology will depend on a better standardization of the immunological reagents, a simplification of logistic problems and a significant reduction of the costs." 06/01/1999 - "The discovery of KSHV in a subset of malignant lymphomas has allowed the development of lymphoma cell lines which now serve as biological reagents for propagating the virus, as a substrate for serologic assays, and as a model system for pathobiologic studies. " 12/01/1987 - "Its advantage lies in its sensitivity and greater B cell specificity than any of the B cell related reagents currently available for the study of malignant lymphoma in fixed tissues." 05/01/2010 - "The same reagents demonstrated cytoplasmic labelling of more than 5% of cells in all 83 lymphoma samples tested with polyclonal antiserum and in 67 of 82 (82%) of samples tested with monoclonal antiserum. " 01/01/2005 - "We will highlight how improvements in our understanding of lymphoma biology rapidly facilitate the development of new diagnostic reagents that could be used to alter clinical practice. "
5.	Tuberculosis (Tuberculoses) 12/01/2001 - "Use of the information gained from sequencing the Mycobacterium tuberculosis genome will enable scientists to accelerate the development of reagents for improved tuberculosis control. " 03/01/2015 - "Reagents from humans are usually cross-reactive with macaques, further facilitating the use of this model system to study tuberculosis. " 01/01/2004 - "A decisive role in enhancing the effectiveness of detection of patients with tuberculosis by the Ziel-Nielsen test is played by the following factors: training of laboratory personnel; provision of laboratories with high-grade equipment and reagents; introduction of the methods and techniques unified and approved by the Ministry of Health of the Russian Federation; regular supervision of jurisdictional laboratories; outside control of the quality of studies. " 01/01/2015 - "There were many health centers that had no or only low stocks of key tuberculosis laboratory reagents and consumables as a result of ineffective distribution system. " 01/01/2015 - "Of the 82 health centers, 77 (93.9%) did not fulfill the criteria for effective distribution of tuberculosis laboratory reagents and consumables. "

Related Drugs and Biologics

1.	Antigens
2.	Antibodies
3.	Vaccines
4.	DNA (Deoxyribonucleic Acid)
5.	Monoclonal Antibodies
6.	Peptides
7.	Penicillins (Penicillin)
8.	Paraffin
9.	Proteins (Proteins, Gene)
10.	T-Cell Antigen Receptors (T-Cell Receptor)

Related Therapies and Procedures

1.	Immunotherapy
2.	Therapeutics
3.	Drug Therapy (Chemotherapy)
4.	Autologous Transplantation
5.	Injections