Hereditary Spastic Paraplegia

A group of inherited diseases that share similar phenotypes but are genetically diverse. Different genetic loci for autosomal recessive, autosomal dominant, and x-linked forms of hereditary spastic paraplegia have been identified. Clinically, patients present with slowly progressive distal limb weakness and lower extremity spasticity. Peripheral sensory neurons may be affected in the later stages of the disease. (J Neurol Neurosurg Psychiatry 1998 Jan;64(1):61-6; Curr Opin Neurol 1997 Aug;10(4):313-8)
Also Known As:
Spastic Paraplegia, Hereditary; Autosomal Dominant Hereditary Spastic Paraplegia; Autosomal Dominant Spastic Paraplegia Hereditary; Autosomal Recessive Hereditary Spastic Paraplegia; Autosomal Recessive Spastic Paraplegia, Hereditary; HMSN Type V; HMSN V (Hereditary Motor and Sensory Neuropathy Type V); Hereditary Autosomal Dominant Spastic Paraplegia; Hereditary Autosomal Recessive Spastic Paraplegia; Hereditary Motor-Sensory Neuropathy with Pyramidal Signs; Hereditary Spastic Paraplegia, Autosomal Recessive; Hereditary X-Linked Recessive Spastic Paraplegia; Hereditary, Spastic Paraplegia, Autosomal Dominant; Hereditary, Spastic Paraplegia, X-Linked Recessive; Hypertrophic Motor-Sensory Neuropathy-Spastic Paraplegia; Paraplegia, Spastic, Hereditary; Spastic Paraplegia, Autosomal Dominant, Hereditary; Spastic Paraplegia, Autosomal Recessive, Hereditary; Spastic Paraplegia, Hereditary, Autosomal Dominant; Spastic Paraplegia, Hereditary, Autosomal Recessive; Spastic Paraplegia, Hereditary, X-Linked Recessive; Spastic Paraplegia, X-Linked Recessive, Hereditary; Spastic Paraplegia-Hypertrophic Motor-Sensory Neuropathy; Type V Hereditary Motor and Sensory Neuropathy; X-linked Recessive Hereditary Spastic Paraplegia; Hereditary Motor Sensory Neuropathy with Pyramidal Signs; Hereditary Spastic Paraplegias; Hereditary X Linked Recessive Spastic Paraplegia; Hypertrophic Motor Sensory Neuropathy Spastic Paraplegia; Paraplegia, Hereditary Spastic; Paraplegias, Hereditary Spastic; Spastic Paraplegia Hypertrophic Motor Sensory Neuropathy; Spastic Paraplegias, Hereditary; Type V, HMSN; X linked Recessive Hereditary Spastic Paraplegia; X-Linked, Spastic Paraplegia, Hereditary
Networked: 187 relevant articles (5 outcomes, 9 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Paraplegia (Spastic Paraplegia)
2. Atrophy
3. Muscle Spasticity (Spastic)
4. Mental Retardation (Idiocy)
5. Spinocerebellar Ataxias (Spinocerebellar Ataxia)


1. Blackstone, Craig: 12 articles (05/2015 - 12/2003)
2. Stevanin, Giovanni: 9 articles (08/2015 - 11/2007)
3. Brice, Alexis: 8 articles (08/2015 - 11/2007)
4. Reid, Evan: 8 articles (08/2012 - 11/2002)
5. Durr, Alexandra: 7 articles (08/2015 - 11/2007)
6. Züchner, Stephan: 6 articles (01/2015 - 08/2006)
7. Zhu, Peng-Peng: 6 articles (11/2014 - 12/2003)
8. Rugarli, Elena I: 6 articles (01/2008 - 06/2004)
9. Mochel, Fanny: 5 articles (08/2015 - 06/2009)
10. Schöls, Ludger: 5 articles (01/2015 - 01/2012)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Hereditary Spastic Paraplegia:
1. BaclofenFDA LinkGeneric
2. Type A Botulinum Toxins (Botulinum A Toxin)FDA Link
3. Ursodeoxycholic Acid (Urso)FDA LinkGeneric
4. Chenodeoxycholic Acid (Chenix)FDA Link
5. Spastic paraplegia 17IBA
6. Proteins (Proteins, Gene)IBA
7. Mitochondrial Proteins (Mitochondrial Protein)IBA
8. Levodopa (L Dopa)FDA LinkGeneric
9. Pontocerebellar Hypoplasia Type 1IBA
10. RNA (Ribonucleic Acid)IBA

Therapies and Procedures

1. Ligation
2. Injections
3. Drug Therapy (Chemotherapy)
4. Activities of Daily Living (ADL)