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Spinocerebellar Ataxias (Spinocerebellar Ataxia)

A group of predominately late-onset, cerebellar ataxias which have been divided into multiple subtypes based on clinical features and genetic mapping. Progressive ataxia is a central feature of these conditions, and in certain subtypes POLYNEUROPATHY; DYSARTHRIA; visual loss; and other disorders may develop. (From Joynt, Clinical Neurology, 1997, Ch65, pp 12-17; J Neuropathol Exp Neurol 1998 Jun;57(6):531-43)
Also Known As:
Spinocerebellar Ataxia; Spinocerebellar Ataxia Type 6; Spinocerebellar Atrophy; Autosomal Dominant Cerebellar Ataxia, Type II; Cerebellar Degeneration with Slow Eye Movements; Cerebelloparenchymal Disorder I; Dominantly-Inherited Spinocerebellar Ataxias; Menzel Type OPCA; OPCA with Macular Degeneration and External Ophthalmoplegia; OPCA with Retinal Degeneration; Olivopontocerebellar Atrophy 2; Olivopontocerebellar Atrophy I; Olivopontocerebellar Atrophy II; Olivopontocerebellar Atrophy III; Olivopontocerebellar Atrophy IV; Olivopontocerebellar Atrophy, Holguin Type; SCA1; Schut-Haymaker Type OPCA; Spinocerebellar Ataxia 1; Spinocerebellar Ataxia 2; Spinocerebellar Ataxia 4; Spinocerebellar Ataxia 5; Spinocerebellar Ataxia 6; Spinocerebellar Ataxia 7; Spinocerebellar Ataxia with Slow Eye Movements; Spinocerebellar Ataxia, Autosomal Dominant, with Sensory Axonal Neuropathy; Spinocerebellar Ataxia, Cuban Type; Spinocerebellar Ataxia-1; Spinocerebellar Ataxia-2; Spinocerebellar Ataxia-4; Spinocerebellar Ataxia-5; Spinocerebellar Ataxia-6; Spinocerebellar Ataxia-7; Spinocerebellar Ataxias, Dominantly-Inherited; Spinocerebellar Atrophy 2; Spinocerebellar Atrophy I; Spinocerebellar Atrophy II; Spinocerebellar Degeneration with Slow Eye Movements; Type 1 Spinocerebellar Ataxia; Type 2 Spinocerebellar Ataxia; Type 4 Spinocerebellar Ataxia; Type 5 Spinocerebellar Ataxia; Type 6 Spinocerebellar Ataxia; Type 7 Spinocerebellar Ataxia; Wadia Swami Syndrome; Wadia-Swami Syndrome; Ataxia 1, Spinocerebellar; Ataxia 2, Spinocerebellar; Ataxia 4, Spinocerebellar; Ataxia 5, Spinocerebellar; Ataxia 6, Spinocerebellar; Ataxia 7, Spinocerebellar; Ataxia, Dominantly-Inherited Spinocerebellar; Ataxia, Spinocerebellar; Ataxias, Dominantly-Inherited Spinocerebellar; Ataxias, Spinocerebellar; Atrophies, Spinocerebellar; Atrophy 2, Olivopontocerebellar; Atrophy 2, Spinocerebellar; Atrophy 2s, Olivopontocerebellar; Atrophy 2s, Spinocerebellar; Atrophy I, Olivopontocerebellar; Atrophy I, Spinocerebellar; Atrophy II, Olivopontocerebellar; Atrophy III, Olivopontocerebellar; Atrophy IIs, Spinocerebellar; Atrophy IV, Olivopontocerebellar; Atrophy IVs, Olivopontocerebellar; Atrophy, Spinocerebellar; Cerebelloparenchymal Disorder Is; Dominantly Inherited Spinocerebellar Ataxias; Dominantly-Inherited Spinocerebellar Ataxia; OPCA, Menzel Type; OPCA, Schut-Haymaker Type; Olivopontocerebellar Atrophy 2s; Olivopontocerebellar Atrophy IIIs; Olivopontocerebellar Atrophy IIs; Olivopontocerebellar Atrophy IVs; Olivopontocerebellar Atrophy Is; SCA1s; Schut Haymaker Type OPCA; Spinocerebellar Ataxia 1s; Spinocerebellar Ataxia 2s; Spinocerebellar Ataxia 4s; Spinocerebellar Ataxia 5s; Spinocerebellar Ataxia 6s; Spinocerebellar Ataxia 7s; Spinocerebellar Ataxia, Dominantly-Inherited; Spinocerebellar Ataxias, Dominantly Inherited; Spinocerebellar Atrophy 2s; Spinocerebellar Atrophy IIs; Spinocerebellar Atrophy Is; Swami Syndrome, Wadia; Syndrome, Wadia Swami; Syndrome, Wadia-Swami; Spinocerebellar Ataxia Type 1; Spinocerebellar Ataxia Type 2; Spinocerebellar Ataxia Type 4; Spinocerebellar Ataxia Type 5; Spinocerebellar Ataxia Type 7
Networked: 2083 relevant articles (69 outcomes, 175 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Spinocerebellar Ataxias (Spinocerebellar Ataxia)
2. Ataxia (Dyssynergia)
3. Neurodegenerative Diseases (Neurodegenerative Disease)
4. Huntington Disease (Huntington's Disease)
5. Alzheimer Disease (Alzheimer's Disease)

Experts

1. Orr, Harry T: 57 articles (01/2022 - 01/2002)
2. Zoghbi, Huda Y: 52 articles (01/2022 - 01/2002)
3. Brice, Alexis: 32 articles (01/2022 - 01/2002)
4. Durr, Alexandra: 25 articles (01/2022 - 08/2004)
5. La Spada, Albert R: 25 articles (11/2021 - 06/2002)
6. Auburger, Georg: 24 articles (08/2022 - 09/2004)
7. Lee-Chen, Guey-Jen: 24 articles (11/2020 - 10/2008)
8. Pulst, Stefan M: 23 articles (01/2022 - 07/2003)
9. Ishikawa, Kinya: 22 articles (01/2022 - 04/2003)
10. Chen, Chiung-Mei: 21 articles (01/2022 - 10/2008)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Spinocerebellar Ataxias:
1. Proteins (Proteins, Gene)FDA Link
2. Ataxin-1IBA
3. CalciumIBA
4. polyglutamineIBA
5. Ataxin-7IBA
6. Varenicline (Chantix)FDA Link
7. Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
8. Brain-Derived Neurotrophic Factor (BDNF)IBA
9. Succinic Acid (Succinate)IBA
10. Biomarkers (Surrogate Marker)IBA

Therapies and Procedures

1. Therapeutics
2. Spinal Injections
3. Transcranial Direct Current Stimulation
4. Transcranial Magnetic Stimulation
5. Neurological Rehabilitation