Neurodegenerative Diseases (Neurodegenerative Disease)

7375  relevant articles (227 outcomes, 542 trials/studies) found for this Disease

Neurodegenerative Disease; Neurodegenerative Disorders; Degenerative Diseases, Central Nervous System; Degenerative Diseases, Neurologic; Degenerative Diseases, Spinal Cord; Degenerative Neurologic Diseases; Degenerative Neurologic Disorders; Nervous System Degenerative Diseases; Neurologic Degenerative Conditions; Neurologic Degenerative Diseases; Neurologic Diseases, Degenerative; Degenerative Condition, Neurologic; Degenerative Conditions, Neurologic; Degenerative Neurologic Disease; Degenerative Neurologic Disorder; Neurodegenerative Disorder; Neurologic Degenerative Condition; Neurologic Degenerative Disease; Neurologic Disease, Degenerative; Neurologic Disorder, Degenerative; Neurologic Disorders, Degenerative; Degenerative Diseases, Nervous System

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Parkinson Disease (Parkinson's Disease)
2.	Alzheimer Disease (Alzheimer's Disease)
3.	Stroke (Strokes)
4.	Neoplasms (Cancer)
5.	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease)

Experts

1.	Youdim, Moussa B H: 14 articles (08/2008 - 03/2004)
2.	Mattson, Mark P: 7 articles (07/2008 - 03/2003)
3.	Butterfield, D Allan: 6 articles (12/2006 - 09/2002)
4.	Amit, Tamar: 5 articles (08/2008 - 03/2004)
5.	Lee, Virginia M-Y: 5 articles (12/2007 - 01/2004)
6.	Greig, Nigel H: 5 articles (09/2007 - 01/2004)
7.	Dickson, Dennis W: 4 articles (08/2008 - 11/2002)
8.	Trojanowski, John Q: 4 articles (12/2007 - 03/2004)
9.	Bar-Am, Orit: 4 articles (11/2007 - 02/2005)
10.	Montine, Thomas J: 4 articles (08/2006 - 07/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Neurodegenerative Diseases:

1.	Proteins (Proteins, Gene)IBA 01/01/2005 - "Studies of proteins, cells, animal models, and humans suggest that treatments to diminish, or bypass, the reduction in KGDHC might be beneficial in age-related neurodegenerative disorders." 03/01/1996 - "Enhanced permeability following modification might allow the use of systematic delivery of these proteins for practical therapeutic treatment of various neurodegenerative disorders." 10/01/2006 - "In this review, we will describe how induction of autophagy is protective against toxic intracytosolic aggregate-prone proteins that cause a range of neurodegenerative diseases" 05/01/2003 - "Immunization against extracellular neurotoxic proteins has shown promise in the treatment of several neurodegenerative disorders" 05/16/1998 - "Impaired clearance of oxidised proteins in neurodegenerative diseases." Order ALL the reference details at left...
2.	Nerve Growth Factors (Neurotrophins)IBA 09/01/2001 - "Since neurotrophins themselves are not ideal drug candidates due to their poor pharmacokinetic behaviour and bioavailability, small molecule neurotrophin mimetics may be beneficial in treating a number of neurodegenerative disorders" 11/10/1996 - "Neurotrophic factors hold promise for the treatment of neurodegenerative diseases" 01/01/1994 - "For example, neurotrophins might function as long term mediators of changes in cellular shapes under the influence of electrical activity, as well as in pathological situations when axonal elongation is needed to restore connections, or to maintain the well-being of neurons that are eliminated during the course of neurodegenerative diseases." 09/01/2008 - "Recent studies have claimed that these neurotrophic factors are important tools for therapeutic intervention in neurodegenerative diseases" 12/01/2007 - "These results suggest more studies in the effect of a combinatorial use of neurotrophins on different sites of brain need to be carried out to develop gene therapy protocols for neurodegenerative diseases." Order ALL the reference details at left...
3.	AntioxidantsIBA 06/01/2005 - "Mitochondria under oxidative stress are thought to play a key role in various neurodegenerative disorders; therefore protection by antioxidants against oxidative stress to mitochondria may prove to be beneficial in delaying the onset or progression of these diseases" 04/15/2003 - "The association between the reduced number of apoptotic cells and the reduction in inclusion bodies may explain in part the increased longevity of mice fed CAT, and supports the contention that the combined actions of selected antioxidants may be therapeutically effective against neurodegenerative diseases." 01/30/2007 - "Recently, clinical trials of several neurodegenerative diseases have increasingly targeted the evaluation of the effectiveness of various antioxidants" 12/15/2004 - "Clinical trials of several neurodegenerative diseases have increasingly targeted the evaluation of various antioxidants' effectiveness" 07/01/2002 - "BACKGROUND: Previous studies raise the possibility that antioxidants protect against neurodegenerative diseases" Order ALL the reference details at left...
4.	Glutamic Acid (Glutamate)FDA Link 04/01/2007 - "These data indicated that 3d and 4c have significant protective effect on nerve cell against glutamate injury, deserved to be further tested and maybe helpful for treatment of neurodegenerative disease." 12/01/2004 - "Taken together, our results demonstrate that the inhibition of glutamate release via activation of the CB1-cannabinoid receptor is one mechanism involved in Delta9-THC-induced impairment of spatial memory, and the therapeutic effect of Delta9-THC on EAE, and a Delta9-THC analog might provide an effective treatment for psychosis and neurodegenerative diseases." 12/09/2003 - "Because an increased glutamate outflow is thought to play a crucial role in triggering excitotoxic neuronal death, drugs able to regulate glutamate release could be effective for the management of neurodegenerative diseases" 06/01/2003 - "Thus neuronal protection against glutamate-induced neurotoxicity is considered as an appropriate therapeutic strategy for preventing and treating neurodegenerative diseases" 03/05/2008 - "Additionally, combined use of both drugs may be warranted for clinical trials to treat glutamate-related neurodegenerative diseases." Order ALL the reference details at left...
5.	Estrogens (Estrogen)FDA Link 01/01/2004 - "Based on estrogen-inducible mechanisms, which have been elucidated in healthy neuron model systems, it would be predicted that estrogen therapy could be highly effective in preventing neurodegenerative disease by promoting neuronal defence and memory mechanisms" 06/01/2003 - "Experimental and epidemiologic studies as well as clinical trials have demonstrated that estrogen is beneficial for the course of neurodegenerative disorders such as Parkinson and Alzheimer diseases but may also protect neurons from postischemic neuronal degeneration" 04/01/1999 - "Potential protective effects of the gonadal steroid estrogen on neurons are of particular interest in aging, neurodegenerative disease, and other traumatic conditions" 01/01/2006 - "In summary estrogen can display a wide range of neuroprotective activities through different types of mechanisms and we are only understanding part of the molecular control of these activities which may help to develop neuropreventive strategies against neurodegenerative diseases in the future." 01/01/2004 - "In summary, the time at which estrogen therapy is initiated, the neurological status of the brain at the time of estrogen therapy initiation and the type of progestogen used all contribute to the efficacy of estrogen in preventing neurodegenerative disease and to sustaining neurological health and function" Order ALL the reference details at left...
6.	Amyloid (Amyloid Fibrils)IBA 08/01/2006 - "Complement activation may also reduce the accumulation of amyloid and degenerating neurons by promoting their clearance and suggest that certain inflammatory defense mechanisms in the brain may be beneficial in neurodegenerative disease" 04/03/2007 - "On the basis of data from mouse models of neurodegenerative diseases showing that exercise or environmental enrichment reduces the amyloid oligomer level and improves cognitive ability, we hypothesized that CryAB(R120G)-induced DRM would also respond favorably to prolonged voluntary exercise, reducing HF symptoms and rescuing the mice from premature death" 01/01/2005 - "Furthermore, the success in the development of amyloid-imaging agents helps with the development of imaging agents for in vivo studies of other AD pathologies in particular and of neurodegenerative disorders in general." 02/07/2000 - "We wanted to further study amyloid Abeta protein alterations in non-AD neurodegenerative diseases" 08/01/2008 - "Amyloid fibers are filamentous proteinaceous structures commonly associated with mammalian neurodegenerative diseases" Order ALL the reference details at left...
7.	N-Methylaspartate (NMDA)IBA 05/01/2004 - "With the use of ChEI and NMDA-receptor antagonist therapy, the symptoms and outcomes of this devastating neurodegenerative disease can be improved and its course altered." 05/01/2007 - "For this reason many previous NMDA receptor antagonists have disappointingly failed advanced clinical trials for a number of neurodegenerative disorders" 04/01/2005 - "For this reason many previous NMDA receptor antagonists have disappointingly failed advanced clinical trials for a number of neurodegenerative disorders" 12/01/2004 - "For this reason many previous NMDA receptor antagonists have disappointingly failed advanced clinical trials for a number of neurodegenerative disorders" 11/27/2007 - "Ngb may protect neurons from NMDA and Abeta toxicity by inhibiting the formation of a death-signaling membrane complex, and interventions that increase Ngb expression could have therapeutic application in AD and other neurodegenerative disorders." Order ALL the reference details at left...
8.	MelatoninIBA 01/01/2003 - "Melatonin, the main secretory product of the pineal gland, has been shown to be potentially effective in prevention of numerous types of neurodegenerative disorders in which free radical processes are involved" 06/01/2002 - "Melatonin administration has been shown to be effective in counteracting the neurodegenerative conditions both in experimental models of neurodegenerative diseases and in patients suffering from such diseases" 07/01/2003 - "The results support the hypothesis that melatonin can be useful in the treatment of neurodegenerative diseases." 10/01/2001 - "The study demonstrates the effectiveness of melatonin in preventing the cognitive deficits as well as the oxidative stress caused by ICV STZ in rats and suggests it's potential in age and age-related neurodegenerative disorders where oxidative stress and cognitive impairment are involved." 10/01/2008 - "Melatonin plays an important role in neurodegenerative diseases as an antioxidant and neuroprotector" Order ALL the reference details at left...
9.	Reactive Oxygen Species (Oxygen Radicals)IBA 01/01/2000 - "Oxidative stress is a major cause of neurodegenerative diseases, so the protection of neuronal cells from reactive oxygen species can be beneficial for the prevention and treatment of these diseases" 04/01/2008 - "Brain aging has become an area of intense research and a subject of much speculation fueled largely from the widely recognized fact that age is the biggest risk factor in most neurodegenerative diseases and age-related increase of reactive oxygen species is particularly detrimental to postmitotic tissues" 01/01/2008 - "An increasing number of reports suggest the involvement of oxidative stress in neurodegenerative diseases where the increased formation of reactive oxygen species (ROS) leads to neuronal damage and cell death" 10/24/2007 - "Mitochondria are a major source of reactive oxygen species (ROS) and oxidative stress, key contributors to aging and neurodegenerative disorders" 08/01/2007 - "The generation of reactive oxygen species (ROS) and resultant oxidative stress has been implicated in the mechanism of brain dysfunction due to age-related neurodegenerative diseases" Order ALL the reference details at left...
10.	Glial Cell Line-Derived Neurotrophic Factor (GDNF)IBA 11/01/2000 - "Glial cell line-derived neurotrophic factor (GDNF) as a defensive molecule for neurodegenerative disease: a tribute to the studies of antonia vernadakis on neuronal-glial interactions." 07/01/2008 - "However, the actual role of endogenous GDNF in the normal adult brain is unknown, even though GDNF-based therapies are considered promising for neurodegenerative disorders" 11/01/2006 - "The identification of a GDNF-mediated, autoregulatory long-lasting feedback loop could have important implications for GDNF's potential value as a treatment for addiction and neurodegenerative diseases." 03/22/2006 - "Glial cell line-derived neurotrophic factor (GDNF) is an important neurotrophic factor that has therapeutic implications for neurodegenerative disorders" 04/01/2003 - "Glial cell line-derived neurotrophic factor (GDNF) has received much attention as potential therapeutic agent for the treatment of neurodegenerative diseases" Order ALL the reference details at left...

Therapies and Procedures

1.	Transplantation (Transplant Recipients) 06/01/2008 - "The rhesus macaque is the most relevant preclinical model for assessing the benefit, safety, and efficacy of ESC-based transplantations in the treatment of neurodegenerative diseases" 01/01/2006 - "Future studies should focus on predifferentiating NSC towards specific neuronal phenotypes prior to transplantation in order to restore behavioral function in rodent models of neurodegenerative disease." 01/01/2006 - "If clinical trials with autologous NSCs are pursued as a treatment option for neurodegenerative diseases, then lessons and insights from many years of clinical trials with fetal neural transplantation for Parkinson's and Huntington's diseases will be invaluable, and should be heeded" 02/01/2004 - "Preliminary stem transplantation trials have already been performed for some neurodegenerative diseases" 11/20/1999 - "Clinical trials of transplantation of pig cells and tissues to treat diabetes and neurodegenerative disorders are in progress" Order ALL the reference details at left...
2.	Therapeutics 01/01/2007 - "In addition, we discuss the drug discovery process and two approaches, function-driven and target-based, that show promise for development of neuroinflammation-targeted, disease-modifying therapeutics for multiple neurodegenerative disorders." 10/01/2007 - "Finally, we discuss how the development of therapeutics to attenuate MMP activity in neurodegenerative disorders may become powerful tools for future studies of synaptic formation and function within the developing and mature brain." 03/01/2008 - "Elucidation of this pathway may have important implications for the development of metal ligand based therapeutics for treatment of AD and other neurodegenerative disorders." 01/01/2008 - "Reduction in the mechanical stress in combination with other conventional aspects should facilitate the development of rational therapeutics for these neurodegenerative disorders." 12/01/2007 - "Excessive glial cell activation may thus constitute a viable target for the discovery of and development of neurodegenerative disease therapeutics" Order ALL the reference details at left...
3.	Transplants (Transplant) 02/10/1997 - "Rats receiving chronic treatment with CsA at a dose of 10 mg kg-1, i.p., daily for 26 days, as used in neural transplants for animal models of neurodegenerative disorders did not significantly differ from vehicle-treated rats, and even appeared slightly improved, in retention of a passive avoidance task" 01/01/2001 - "10 years of substitution therapy for neurodegenerative diseases using fetal neuron grafts: a positive outcome but with questions for the future]" 11/20/2005 - "Sertoli cells are considered 'nurse cells' in the seminiferous tubules and have been used in cell graft protocols for neurodegenerative diseases and diabetes in many studies" 05/16/2007 - "Experimental validation of cell replacement therapy as a treatment of neurodegenerative diseases requires the demonstration of graft-mediated behavioural recovery" 03/01/2007 - "Cell replacement therapies for neurodegenerative diseases, using multipotent neural stem cells (NSCs), require above all, a good survival of the graft" Order ALL the reference details at left...
4.	Stem Cell Transplantation 10/01/2008 - "Novel therapeutic approaches using stem cell transplantation to treat neurodegenerative diseases have yielded promising results" 12/01/2007 - "Stem cell transplantation for neurodegenerative diseases." 12/01/2006 - "Neural stem cell transplantation is a promising strategy for the treatment of neurodegenerative diseases" 03/01/2004 - "The emerging technologies of neural xenografting and stem cell transplantation for treating neurodegenerative disorders." 02/01/2004 - "The emerging technologies of neural xenografting and stem cell transplantation for treating neurodegenerative disorders." Order ALL the reference details at left...
5.	Investigational Therapies (Experimental Therapy) 07/01/1996 - "For these reasons, mGlu receptors can be considered as promising drug targets in the experimental therapy of acute or chronic neurodegenerative diseases." 09/01/1995 - "We conclude that agonists of class II or III mGluRs are of potential interest in the experimental therapy of acute or chronic neurodegenerative disorders." 10/01/2008 - "Understanding the molecular mechanisms of brain preconditioning holds promise in developing innovative therapies to prevent and treat neurodegenerative disorders, particularly ischemic stroke" 12/04/2007 - "Network biomarkers may be used as physiological assays in early-phase trials of experimental therapies for PD and other neurodegenerative disease." 06/01/2001 - "These data confirm that AIT-082 is of potential interest for the experimental therapy of neurodegenerative disorders." Order ALL the reference details at left...