Paraplegia (Spastic Paraplegia)

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1378 relevant articles (52 outcomes, 71 trials/studies) found for this Disease

Description: Severe or complete loss of motor function in the lower extremities and lower portions of the trunk. This condition is most often associated with SPINAL CORD DISEASES, although BRAIN DISEASES; PERIPHERAL NERVOUS SYSTEM DISEASES; NEUROMUSCULAR DISEASES; and MUSCULAR DISEASES may also cause bilateral leg weakness.

Also Known As:

Spastic Paraplegia; Flaccid Paraplegia; Paralysis, Legs; Paralysis, Lower Limbs; Paraplegia, Ataxic; Paraplegia, Cerebral; Paraplegia, Flaccid; Paraplegia, Spinal; Ataxic Paraplegia; Ataxic Paraplegias; Cerebral Paraplegia; Cerebral Paraplegias; Flaccid Paraplegias; Paraplegias; Paraplegias, Ataxic; Paraplegias, Cerebral; Paraplegias, Flaccid; Paraplegias, Spastic; Paraplegias, Spinal; Spastic Paraplegias; Spinal Paraplegia; Spinal Paraplegias; Paralysis, Lower Extremities; Paraplegia, Spastic

Relationship Network

Disease Context: Research Results

Nervous System Diseases: 3643

Neurologic Manifestations: 3015

Paralysis: 7000

Paraplegia: 1378

Brown-Sequard Syndrome: 13

Signs and Symptoms Pathological Conditions

Signs and Symptoms

Neurologic Manifestations: 3015

Paralysis: 7000

Paraplegia: 1378

Brown-Sequard Syndrome: 13

Related Diseases

1.	Paraplegia (Spastic Paraplegia)
2.	Spinal Cord Ischemia
3.	Hypothermia
4.	Aneurysm (Aneurysms)
5.	Ischemia

Experts

1.	Singh, G: 3 articles (05/2005 - 01/2002)
2.	Soni, B M: 3 articles (05/2005 - 01/2002)
3.	Vaidyanathan, S: 3 articles (05/2005 - 01/2002)
4.	Hughes, P L: 3 articles (05/2005 - 01/2002)
5.	Sett, P: 2 articles (05/2005 - 01/2004)
6.	Mansour, P: 2 articles (01/2004 - 01/2002)
7.	Bayliss, C: 1 article (09/2008)
8.	Silburn, P A S: 1 article (09/2008)
9.	SHAPE-SCI Research Group: 1 article (09/2008)
10.	Buchholz, A C: 1 article (09/2008)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Paraplegia:

1.	Calcitonin (Calcitonin, Eel)FDA LinkGeneric 09/01/1977 - "[Paget's paraplegia successfully treated with calcitonin with a remission of more than 4 years]" 04/30/1977 - "[Paget's paraplegia, treated successfully with calcitonin, with remission lasting over 3 years]" 03/13/1976 - "Improvement in paraplegia in vertebral Paget's disease treated with calcitonin." 07/01/1994 - "In contrast, plasma calcitonin concentration in the quadriplegic group was significantly higher than that in persons with paraplegia and insignificantly higher than that in the control group. " 01/01/1981 - "The recovery of cord function following calcitonin therapy in patients with paraplegia due to Paget's disease of the vertebral column is likely to be due to enhanced spinal cord perfusion." Order ALL the reference details at left...
2.	Mannitol (Osmitrol)FDA LinkGeneric 09/01/1979 - "The effects of mannitol on the spinal cord blood flow patterns in experimental traumatic paraplegia were correlated with microangiographic and electrophysiologic studies. " 10/01/1995 - "Neuroanesthesia adjunct therapy (mannitol and hyperventilation) is as effective as cerebrospinal fluid drainage for prevention of paraplegia after descending thoracic aortic cross-clamping in the dog." 10/01/1995 - "We compared cerebrospinal fluid (CSF) drainage (Group D; n = 8) to neuroanesthesia adjunct therapy (hyperventilation and mannitol administration; Group N; n = 8) for the prevention of paraplegia using a canine model of descending thoracic aortic cross-clamping (AXC; 2.5 mm distal to the left subclavian artery for 30 min). " 08/01/1993 - "BACKGROUND AND PURPOSE: Using a canine model of thoracic aortic cross-clamping, we compared the incidence and severity of paraplegia with and without standard neuroanesthesia adjuncts (mannitol administration and deliberate hyperventilation). " 01/01/2002 - "Compared with other groups, animals in the 5-Day Paraplegia group had greater incorporation of [(3)H]-D-mannitol and [(14)C]-carboxyl-inulin in lumbar segment 8, corresponding to the location of the epidural catheter tip. " Order ALL the reference details at left...
3.	Methylprednisolone FDA LinkGeneric 01/01/2009 - "Weakness improved after two courses of intravenous infusion of methylprednisolone 1000 mg. On day 67, she developed paraplegia, urinary retention, a Th4 sensory level, and loss of position sense in the lower limbs. " 03/01/1992 - "For example, treatment with methylprednisolone more than doubled the probability that patients would convert from quadriplegia or paraplegia to quadriparesis or paraparesis, analgesia to hypalgesia, and anesthesia to hypesthesia. " 01/01/1990 - "We investigated whether intravenous methylprednisolone (30 mg/kg) before 30 minutes of aortic cross-clamping and after 4 hours could enhance the effects of cerebrospinal fluid drainage on spinal cord perfusion pressure and postoperative paraplegia when proximal blood pressure was controlled with sodium nitroprusside and partial exsanguination. " 02/01/2000 - "METHOD: One hundred and six patients who had spinal trauma (including 48 with paraplegia and 58 with tetraplegia) were randomly separated into four groups: M=methylprednisolone (30 mg x kg(-1) over 1 h, followed by 5.4 mg x kg(-1) x h(-1) for 23 h), N=nimodipine (0.015 mg x kg(-1) x h(-1) for 2 h followed by 0.03 mg x kg(-1)h(-1) for 7 days), MN (both agents) or P (neither medication). " 01/01/1982 - "Therefore, thiopental significantly decreased the incidence of paraplegia, while methylprednisolone and mannitol did not enhance its protective effect." Order ALL the reference details at left...
4.	Baclofen FDA LinkGeneric 09/01/1991 - "Chronic intrathecal baclofen infusion has recently been reported as an effective treatment of the spasticity of paraplegia. " 01/01/1977 - "Clinical and laboratory assessment of the efficacy of baclofen (Lioresal) on urethral sphincter spasticity in patients with traumatic paraplegia." 02/01/2000 - "In this study of a single patient with familial spastic paraplegia, intrathecal baclofen has facilitated the emergence of normal, supraspinally determined movement patterns." 04/01/1981 - "A lactating woman with spastic paraplegia was given 94 mumol (20 mg) of baclofen orally to study the transport of the drug into breast milk. " 12/01/2003 - "METHODS: We present a case of a 38-year-old male with complete T9 spastic paraplegia for 15 years, treated with intrathecal baclofen for 11 years. " Order ALL the reference details at left...
5.	Anti-Bacterial Agents (Antibiotics)IBA 04/01/2008 - "He responded well to antibiotics but was not investigated for causes of paraplegia. " 09/01/2000 - "One patient improved with antibiotics but the second developed paraplegia, a recognized complication of discitis. " 07/15/2004 - "Meningitis was treated with the appropriate antibiotics, and the patient underwent rehabilitation for paraplegia and bladder and bowel incontinence. " 01/01/2004 - "FINDINGS: A 39-year-old man with T10 paraplegia presented with a distended, quiet abdomen following recent treatment with antibiotics for pneumonia. " 01/01/1999 - "Further developments in diagnosis using molecular genetic techniques, more effective antibiotics and more aggressive surgical protocols in the next millennium may help in solving the problems of late severe deformity and paraplegia in the debilitated immunocompromised patients." Order ALL the reference details at left...
6.	Dizocilpine Maleate (Dizocilpine)IBA 01/01/2005 - "CONCLUSION: These results demonstrate that combined temporary clipping of the aortic arch (just proximal to the left common carotid artery) plus left subclavian artery for 17 minutes reproduces reliable paraplegia, and a single dose of MK-801 given before ISCI provides significant neuroprotection." 06/01/1990 - "The effect of a single intramuscular treatment with either MK-801 (3 mg/kg) or ketamine (110 mg/kg) given at the onset of paraplegia was evaluated 30 hours later. " 01/01/1998 - "This study demonstrates that although MK-801 or KB-2796 does not prevent paraplegia due to spinal cord ischemia in the rabbit, both drugs can influence the rate of recovery after ischemic injury." 06/01/1993 - "The NO precursor L-arginine (100-500 mg/kg, IP) and L-NAME (1-125 mg/kg, IP) had no overt effects on animals' behaviour by themselves, while MK-801 (0.1-0.8 mg/kg, IP) caused motor excitability at low doses and sedation and paraplegia at high ones. " 08/01/1994 - "Group MG was improved from groups SA (P = < 0.0039) and CO (P = < 0.0048) at day 4. This study demonstrates that although intrathecal NMDA receptor blockade with MgSO4 or MK-801 does not prevent paraplegia due to spinal cord ischemia in the rat, it could however influence the rate of recovery after ischemic injury." Order ALL the reference details at left...
7.	Glucose (Dextrose)FDA LinkGeneric 05/01/1993 - "This paraplegia was completely reversed with the administration of intravenous glucose. " 03/01/1992 - "Almost half of the 45 active, healthy subjects with paraplegia we studied have a disorder of carbohydrate tolerance, 1 in 5 subjects having a diabetic oral glucose tolerance test. " 10/01/1987 - "Dextrose administration increases sensory/motor impairment and paraplegia after infrarenal aortic occlusion in the rabbit." 06/01/1994 - "Eighty-two percent of the controls had normal (NL) oral glucose tolerance, compared with 38% of those with quadriplegia and 50% of those with paraplegia. " 03/01/1992 - "Subjects with paraplegia having impaired glucose tolerance or diabetes mellitus are significantly older than those with normal glucose tolerance. " Order ALL the reference details at left...
8.	PapaverineIBA 07/01/1986 - "Intrathecal application of papaverine proved to be even more effective in increasing SCBF and also completely prevented paraplegia. " 07/01/1986 - "The preliminary trial using intrathecal papaverine in human beings has thus far shown no adverse side effects from the drug, and no paraplegia has occurred." 03/01/1990 - "We have previously described a technique for intrathecal administration of papaverine and cerebrospinal fluid drainage to prevent paraplegia after aortic surgery. " 12/01/1988 - "Preliminary results and rationale for the use of intrathecal papaverine for the prevention of paraplegia after aortic surgery." 11/01/1988 - "Intrathecal papaverine for the prevention of paraplegia after operation on the thoracic or thoracoabdominal aorta." Order ALL the reference details at left...
9.	Dexamethasone (Maxidex)FDA LinkGeneric 01/01/1994 - "Five years prior to the 1990 publication of the Second National Acute Spinal Cord Injury Study (SNASCIS), a 24-year-old man sustained traumatic paraplegia, and was treated with 797 mg of dexamethasone over the ensuing 26 days. " 04/01/2001 - "Recognizing the symptoms of spinal cord compression and initiating dexamethasone therapy promptly to prevent paraplegia are critical." 02/01/1988 - "Pharmacological intervention with indomethacin compares favorably with dexamethasone in reduction of spinal cord edema and in delaying the onset of paraplegia." 04/01/1991 - "Treatment with either dexamethasone or indomethacin delayed onset of paraplegia but had no effect on 5-HT metabolism. " 10/01/1988 - "The effect of treatment given on onset of paraplegia with either dexamethasone sodium phosphate (Dex-p; 10 mg/kg twice daily), or free dexamethasone (F-dex; 8.25 mg/kg twice daily) or indomethacin (10 mg/kg twice daily), was evaluated after 30 hours of therapy. " Order ALL the reference details at left...
10.	Carbon MonoxideIBA 07/01/2000 - "For a PET(CO(2)) of 70 mm Hg the estimated expiratory muscle contribution to VT was 10.3 and 28.4% (p < 0.02) in patients with paraplegia and normal subjects, respectively. " 09/01/2006 - "While the co-existence of paraplegia and mental nerve neuropathy is a possible feature of metastatic prostate cancer involving the spine and mandible, the concomitant occurrence of multiple facial swellings involving the anterior mandible with its related gingival and lip mucosa, frontal bone and parotid glands is a rare finding. " 07/01/2000 - "Minute ventilation (V E) and mean inspiratory flow responses to hypercapnia were similar in normal subjects and patients with paraplegia, but in the latter, at any given level of end-tidal CO(2) partial pressure (PET(CO(2))), tidal volume (VT) was reduced and frequency was increased. " 06/01/1986 - "In three children with homocarnosinosis the biochemical aberration co-exists with paraplegia, retinitis pigmentosa, and a progressive mental deficiency. " 08/01/2002 - "A range of co-existing health conditions were present among decedents including: blood-bome viruses (BBVs), chronic pain/injury, asthma, epilepsy, diabetes, obesity, kidney disease, cardiac disease, pancreatitis, gall stones, paraplegia, cerebral palsy, schizophrenia, depression, suicidal ideation and arthritis. " Order ALL the reference details at left...

Therapies and Procedures

1.	Decompression 11/01/1997 - "The operative decompression of the spinal cord and stabilization of the injured spine by short segment pedicle instrumentation led to a complete or partial remission of the neurological deficits in 93% of the patients with incomplete paraplegia. " 11/01/1965 - "[Contribution to the study of the problems of spinal cord decompression, of straightening and retention of the spine in late Pott's paraplegia due to a large hump back]" 06/01/2009 - "CONCLUSIONS: Rehabilitation is better after staged anterior decompression and fusion in burst fracture of thoracolumbar junction with complete paraplegia." 06/01/2009 - "Thoracolumbar burst fracture with complete paraplegia: rationale for second-stage anterior decompression and fusion regarding functional outcome." 05/01/2008 - "We also report a similar observation in a 13.5-year-old boy who also suffered from acute paraplegia and had only a partial recovery after urgent decompression." Order ALL the reference details at left...
2.	Drug Therapy (Chemotherapy) 04/01/1997 - "OBJECTIVE: To assess the efficacy of 9-month short-course chemotherapy (SCC) and to study the pattern of neurological recovery in patients with Pott's paraplegia. " 09/01/2003 - "All patients presented with neurological deficits and were treated with chemotherapy initially, after which 3 patients recovered, 4 improved and 6 were aggravated into paraplegia. " 09/01/2004 - "He developed flaccid paraplegia despite radiotherapy of the lumbar spine combined with corticosteroid therapy and chemotherapy. " 10/01/2003 - "Surgical intervention prior to the onset of paraplegia and the prompt initiation of chemotherapy resulted in an excellent neurological and hematological outcome. " 04/01/1997 - "Short-course chemotherapy in the treatment of Pott's paraplegia: report on five year follow-up." Order ALL the reference details at left...
3.	Transplantation (Transplant Recipients) 09/27/2008 - "BACKGROUND: Bone marrow stromal cells (BMSC) transplantation offers promise in the treatment of chronic paraplegia in rodents. " 01/01/1992 - "Omental transplantation in the management of chronic traumatic paraplegia. " 09/01/2008 - "The trial was a Phase I/IIa design whose main aim was to test the feasibility and safety of transplantation of autologous olfactory ensheathing cells into the injured spinal cord in human paraplegia. " 01/01/1997 - "Second, to show, from our own results, obtained from the study of an animal model of paraplegia, the adult spinal rat, how it could be possible to take advantage of the autonomy of the CPG, with special reference to its sensibility to monoamines, to obtain locomotor recovery in hindlimbs after section of the thoracic spinal cord, by means of transplantation of noradrenergic and/or serotonergic embryonic neurons in the lumbo-sacral spinal cord. " 01/01/2009 - "For this reason, we revise our previous experimental findings about neuronal transdifferentiation of BMSC, and the utility of local BMSC transplantation in an experimental model of chronic paraplegia. " Order ALL the reference details at left...
4.	Stents 05/01/2006 - "CONCLUSION: Thoracic aortic stent grafting is a safe procedure in selected patients with the added benefit of a low incidence of paraplegia. " 03/01/2006 - "We report the case of a man who developed paraplegia 36 hours after insertion of 4 stents in the descending thoracic aorta. " 03/01/2006 - "[Cerebrospinal fluid drainage to treat delayed paraplegia after stent grafting of the descending thoracic aorta]" 12/01/2003 - "No other major complication was present and there was no paraplegia after the stent grafting. " 08/01/2003 - "There were two cases of access failure due to small caliber of iliac arteries, and 1 of these patients died shortly after the procedure was abandoned, At 12 months of follow-up, there were no cases of paraplegia, stent migration, or endoleaks. " Order ALL the reference details at left...
5.	Transplants (Transplant) 04/01/2009 - "The reintervention for substituting an infected graft was excluded due to the high risk of death or paraplegia. " 02/01/2009 - "Meta-analysis indicates that endoluminal graft repair is accompanied by lower procedure related mortality (OR 0.46, 95% CI 0.26-0.78, p=0.005) and paraplegia rates (OR 0.23, 95% CI 0.08-0.65, p=0.005), as compared to open repair. " 06/01/2008 - "These changes have resulted in a major reduction of mortality and procedure-related paraplegia but also a significant increase of early graft-related complications." 10/01/2007 - "Graft interposition and cross-clamping of the aorta are responsible for a high paraplegia rate. " 06/01/2007 - "In recent years, endoluminal graft therapy has been increasingly applied to the treatment of thoracic aortic pathologies with decreased morbidity, mortality, and risk of paraplegia. " Order ALL the reference details at left...

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