Nervous System Diseases (Neurological Disorders)

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3338 relevant articles (117 outcomes, 304 trials/studies) found for this Disease

Description: Diseases of the central and peripheral nervous system. This includes disorders of the brain, spinal cord, cranial nerves, peripheral nerves, nerve roots, autonomic nervous system, neuromuscular junction, and muscle.

Also Known As:

Neurological Disorders; Neurological Disorder; Nervous System Disease; Nervous System Disorders; Neurologic Disorder; Neurologic Disorders; Disease, Nervous System; Diseases, Nervous System; Disorder, Nervous System; Disorder, Neurologic; Disorder, Neurological; Disorders, Nervous System; Disorders, Neurologic; Disorders, Neurological; Nervous System Disorder

Relationship Network

Disease Context: Research Results

Nervous System Diseases: 3338

Neurodegenerative Diseases: 7169

Demyelinating Diseases: 3131

Neurologic Manifestations: 2841

Central Nervous System Diseases: 916

Neuromuscular Diseases: 735

Sleep Disorders: 639

Autonomic Nervous System Diseases: 251

Cranial Nerve Diseases: 145

Nervous System Neoplasms: 142

Neurotoxicity Syndromes: 123

Neurocutaneous Syndromes: 64

Nervous System Trauma: 41

Chronobiology Disorders: 35

Nervous System Malformations: 21

Autoimmune Diseases of the Nervous System: 15

Related Diseases

1.	Stroke (Strokes)
2.	Parkinson Disease (Parkinson's Disease)
3.	Epilepsy (Aura)
4.	Alzheimer Disease (Alzheimer's Disease)
5.	Pain (Aches)
584 Diseases and 1539 more articles analyzed in the Full Patient-Physician Summary Report, order at left...

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Nervous System Diseases:

1.	Botulinum Toxins (Botulinum Toxin)IBA 11/01/2002 - "Botulinum toxin has dramatically improved the treatment of a variety of neurologic disorders" 12/01/1997 - "Botulinum toxin (BTX) has become a safe and effective therapeutic tool in the treatment of a variety of neurological disorders, especially dystonias" 01/01/2008 - "Use of botulinum toxin a in adult neurological disorders : efficacy, tolerability and safety." 01/01/2006 - "Botulinum toxin has been shown to effectively treat several types of neurological disorders" 05/01/2004 - "This review focuses on the pharmacology, electrophysiology, immunology, and application of botulinum toxin in selected neurological disorders." Get all the results and reference details, order at left...
2.	Tissue Plasminogen Activator (Alteplase)FDA Link 04/01/2008 - "We report a 93 year-old female subjected to intravenous thrombolysis using tissue plasminogen activator (r-tPA), according to the National Institute of Neurological Disorders protocol" 01/01/2002 - "However, following the randomized trial of intravenous tissue-type plasminogen activator (t-PA) sponsored by the National Institutes of Neurological Disorders and Stroke (NINDS) in 1995, the first proven effective therapy for acute stroke became available" 06/01/2001 - "Reliability of the mNIHSS was assessed with the certification data originally collected to assess the reliability of investigators in the National Institute of Neurological Disorders and Stroke (NINDS) rtPA (recombinant tissue plasminogen activator) Stroke TRIAL: Validity of the mNIHSS was assessed with the outcome results of the NINDS rtPA Stroke Trial: RESULTS: Reliability was improved with the mNIHSS: the number of scale items with poor kappa coefficients on either of the certification tapes decreased from 8 (20%) to 3 (14%) with the mNIHSS" 01/01/2001 - "The publication of the positive results of the National Institute of Neurological Disorders and Stroke (NINDS) trial of alteplase (a recombinant tissue plasminogen activator; rt-PA) for acute stroke patients in 1995 and its approval by the US Food and Drug Administration as well as the American Academy of Neurology and American Heart Association increased the interest and attention of the medical community in acute stroke treatment" 01/01/1999 - "BACKGROUND--With the exception of the National Institutes of Neurological Disorders and Stroke trial of recombinant tissue plasminogen activator, clinical trials in stroke have failed to show improved outcome" Get all the results and reference details, order at left...
3.	Proteins (Proteins, Gene)IBA 10/01/2004 - "Several groups have published the first positive results using protein transduction domains for the delivery of therapeutic proteins in relevant animal models of human neurological disorders" 05/01/2005 - "In human cerebrospinal fluid (CSF), approximately 80% of proteins originate from serum, and removal of major proteins is necessary to study brain-derived proteins that are present at low concentrations for successful biomarker and therapeutic target discoveries for neurological disorders" 03/01/1997 - "Based on the studies reviewed here, we conclude that grafted NT2N cells could serve as a suitable platform for the delivery of exogenous proteins into the CNS for gene therapy of human nervous system diseases." 11/01/1996 - "In this study, localization of Bax and Bcl-2 proteins was investigated in the human central nervous system using autopsy cases without any neurological disorder" 01/01/1993 - "Probes against various synaptic proteins have recently been used to study synaptic alterations in human disease, as well as in experimental models of neurological disorders" Get all the results and reference details, order at left...
4.	gamma-Aminobutyric Acid (GABA)IBA 06/01/1999 - "Pharmacological inhibition of GABA uptake transporters provides a mechanism for increasing GABAergic transmission, which may be useful in the treatment of various neurological disorders" 01/01/1982 - "Trials of drugs enhancing GABA-ergic function have been made in a wide variety of neurological disorders" 04/04/2008 - "Understanding the genetic mechanism behind such changes in alpha subunit expression will lead to a better understanding of the role that signal transduction plays in control over GABA(A)R function and brings with it the promise of providing new therapeutic tools for the prevention or cure of a variety of neurological disorders" 02/01/2006 - "Several neurological disorders such as Alzheimer's and Parkinson's diseases have been attributed to gamma-aminobutyric acid (GABA) depletion in the brain" 05/12/2005 - "This work is therefore expected to facilitate the design and development of new biologically active GABA analogues to treat GABA-related neurological disorders." Get all the results and reference details, order at left...
5.	N-Methylaspartate (NMDA)IBA 07/01/2003 - "The initial promise of the N-methyl-D-aspartate (NMDA) receptor antagonists gave hope for the therapeutic treatment of neurological disorders, which ultimately was unfulfilled" 09/01/1988 - "These findings strongly suggest that Ca2+ entry through N-methyl-D-aspartate-activated channels is responsible for this type of neuronal death and suggest strategies that may be clinically useful in the treatment of various neurological disorders." 02/01/2005 - "This review examines the roles of NMDA receptor subtypes in excitotoxicity and neurological disorders." 01/01/2000 - "These data challenge the notion that extracellular accumulation of endogenous QUIN may contribute to excessive NMDA-receptor activation in some neurological disorders, and the suitability of kynurenine-3-hydroxylase inhibition as an effective anti-excitotoxic strategy." 01/01/1997 - "These data suggest that inhibition of organic anion transport is not, by itself, sufficient to protect against neurological disorders involving excessive NMDA-receptor activation" Get all the results and reference details, order at left...
6.	EnzymesIBA 08/01/2006 - "In this review, we discuss the molecular pathologies of lysosomal diseases from the protein structural aspect, current enzyme replacement therapies, and attempts to develop enzyme replacement therapies effective for lysosomal diseases associated with neurological disorders, i.e., production of enzymes, brain-specific delivery and incorporation of lysosomal enzymes into cells." 08/01/1996 - "Therefore, the predictive value of these enzymes for the development of neurologic disorders in asphyxiated newborns is not adversely affected by the development of an immediately and effectively treated IRDS" 11/15/2005 - "Mutations in enzymes involved in sphingolipid metabolism and trafficking cause a variety of neurological disorders, but details of the molecular pathophysiology remain obscure" 08/01/1990 - "We studied the activity of two enzymes NSE and TK in the biological fluids of 104 patients with nervous system diseases, who fell into 4 groups" 10/01/1970 - "Leucocyte hydrolytic enzymes in the diagnosis of some neurological disorders." Get all the results and reference details, order at left...
7.	Intravenous Immunoglobulins (IVIG)FDA Link 04/01/2005 - "Although the use of IVIG is effective for autoimmune neurological disorders, there are no commonly accepted protocols for the use of IVIG treatment" 04/01/1992 - "The studies cited herein highlight the potential benefits of IVIG therapy in a group of neurological disorders that are associated with aberrant immune responses" 09/01/2006 - "IVIG therapy in neurological disorders of childhood." 04/01/2006 - "Whether different brands of IVIg or different lots of the same brand are comparably efficacious for the treatment of neurological disorders is not clear" 10/01/2003 - "Intravenous immunoglobulins in neurological disorders: safety issues." Get all the results and reference details, order at left...
8.	LigandsIBA 01/01/2000 - "Immunophilin ligands as a novel treatment of neurological disorders." 01/01/2008 - "However, a number of selective 5-HT(2)R ligands currently under development, or in early clinical trials for psychiatric and/or neurological disorders, may soon be available for translational studies to explore their effectiveness in modulating drug use and dependence." 01/01/2006 - "However, a number of selective 5-HT2 R ligands currently under development, or in early clinical trials for psychiatric and/or neurological disorders, may soon be available for translational studies to explore their effectiveness in modulating drug use and dependence." 08/01/2006 - "CCR1 ligands, including CCL3, CCL5, and CCL7, are up-regulated in a number of neurological disorders in humans and animal models" 01/01/2006 - "Some selective nicotinic ligands have recently been developed and used to explore the complexity of nAChR subtype structure and function in the expectation that they will become rational therapeutic alternatives in a number of neurodegenerative, neuropsychiatric and neurological disorders" Get all the results and reference details, order at left...
9.	Dopamine (Intropin)FDA LinkGeneric 04/01/2007 - "Various pharmacological studies have implicated the dopamine D(3) receptor as an interesting therapeutic target in the treatment of different neurological disorders" 09/01/2008 - "The long-term consequences of exposure have become a major human health concern as research has indicated strong associations between neurotoxicants and a variety of dopamine-related neurological disorders" 08/01/2008 - "The effects of 17beta-estradiol (E(2)) on dopamine (DA) transport could explain gender and life-stage differences in the incidence of some neurological disorders" 06/01/2008 - "Dopamine regulates movement, motivation, reward, and learning and is implicated in numerous neuropsychiatric and neurological disorders" 03/01/2008 - "Dopamine (DA) plays an important role in a number of behavioral processes and neurological disorders" Get all the results and reference details, order at left...
10.	OxygenIBA 02/01/2002 - "While no research study has yet demonstrated convincing evidence for the efficacy of Hyperbaric Oxygen Therapy (HBOT) in patients with chronic neurological disorders (CND), anecdotal studies have been supportive of its use in improving healing of the damaged brain" 11/01/1995 - "When neurological disorders were observed, HBO therapy included immediate compression to 6 atm abs for 10 to 15 mn with air followed by decompression to 2 atm abs where the patients received 100% oxygen during 1 hour" 06/01/1993 - "These hypothetical pre- and post-HBO events may set the stage for the development of some delayed neurological disorders, including the retinopathy of prematurity and the retardation of brain development in fetuses or prematurely-born infants subjected to oxygen therapy." 02/29/1996 - "Neurological disorders, such as stroke, trauma, tardive dyskinesia, Alzheimer's and Parkinson's diseases, may be partially attributed to excessive exposition of the nervous tissue to oxygen-derived radicals" 08/31/2006 - "The brain is particularly vulnerable to oxygen free radicals, and these radicals have been implicated in the pathology of several neurological disorders" Get all the results and reference details, order at left...
1214 Drugs and Important Bio-Agents and 2962 more articles analyzed in the Full Patient-Physician Summary Report, order at left...

Therapies and Procedures

1.	Transplantation (Transplant Recipients) 08/15/2004 - "Transplantation of genetically manipulated cells to the central nervous system holds great promise for the treatment of several severe neurological disorders" 12/01/1995 - "After an initial postoperative exacerbation of her neurological disorder the patient developed an impressive remission of her clinical condition during the 4 year post transplantation follow up period" 11/01/2006 - "Transplantation studies have begun in a variety of models in hopes of defining their potential use to treat a wide variety of human conditions, including diabetes and urological and neurological disorders." 11/01/2004 - "In order to verify the biological aspects of 'autogeneic' bone marrow stromal cells (BMSC) transplantation for neurological disorders, we aimed our study towards the assessment of the survival, distribution, and differentiation of autologous BMSC in the central nervous system (CNS)" 08/01/2008 - "The use of olfactory neuroepithelium neural progenitor cells for transplantation has attracted attention in the treatment of many neurological disorders, which require efficient recovery methods and cryopreservation procedures" Get all the results and reference details, order at left...
2.	Plasma Exchange 01/01/1999 - "We investigated 19 patients affected by chronic peripheral neurological disorders treated with therapeutic plasma exchange (TPE) to verify the efficacy of the therapeutic protocol used in these diseases" 01/01/1981 - "Coagulation studies were performed during and after 60 continuous plasma exchanges in 15 patients with neurologic disorders" 04/01/2008 - "Therapeutic plasma exchange (TPE) is commonly used in many neurological disorders where an immune etiology was known or suspected" 02/01/2007 - "Plasma exchange is a therapeutic procedure commonly used in various neurological disorders" 02/01/2007 - "Plasma exchange as a therapeutic option in neurological disorders]" Get all the results and reference details, order at left...
3.	Drug Therapy (Chemotherapy) 04/01/2008 - "Distinguishing the beneficial from the detrimental effects of PMN on neurons may aid in the development of more effective drug therapies for neurological disorders involving neuroinflammation, including painful neuropathies." 04/01/2008 - "Voltage-gated Ca(2+) channels in etiology, pathogenesis, and pharmacotherapy of neurologic disorders]" 09/01/2007 - "By providing a fine-tuning mechanism these receptors also offer attractive sites for pharmacotherapy in nervous system diseases" 08/01/2007 - "The market for neuropharmaceuticals is potentially one of the largest sectors of the global pharmaceutical market owing to the increase in average life expectancy and the fact that many neurological disorders have been largely refractory to pharmacotherapy" 06/01/2006 - "These results contribute to understanding sex differences in stimulant-induced locomotor activity in rats and may have broader implications for neurologic disorders and their pharmacotherapies in humans." Get all the results and reference details, order at left...
4.	Therapeutics 11/01/2006 - "Identification of unique effectors in AA metabolism could direct the development of new therapeutics holding significant promise for the prevention and treatment of neurological disorders." 11/01/2001 - "Standardization of specific behavioral paradigms and phenotyping strategies will ensure that these behavioral mouse mutants offer robust models for evaluating the efficacy of novel therapeutics in the treatment of hereditary neurological disorders" 02/01/2008 - "This method provides a simple and sensitive cell-based assay for screening of PDE10 inhibitors for development of novel therapeutics for the treatment of neurological disorders." 06/01/2006 - "This discourse highlights the successes and challenges encountered using HSV amplicon vectors as tools for the dissection of neural network function and as therapeutics directed against a variety of neurologic disorders." 06/01/2006 - "In vivo, magnetic resonance spectroscopy interrogates metabolite distributions in living cells and tissues with increasing precision, which significantly impacts the development of anticancer or neurological disorder therapeutics" Get all the results and reference details, order at left...
5.	Deep Brain Stimulation 09/01/2007 - "The mismatch between the extensive clinical use of deep brain stimulation (DBS), which is being used to treat an increasing number of neurological disorders, and the lack of understanding of the underlying mechanisms is confounded by the difficulty of measuring the spread of electric current in the brain in vivo" 09/01/2007 - "Chronic, high-frequency electrical stimulation of subcortical brain structures (deep brain stimulation [DBS]) is an effective clinical treatment for several medically refractory neurological disorders" 02/01/2007 - "Deep brain stimulation in neurologic disorders." 03/01/2006 - "Deep brain stimulation (DBS) is an established clinical treatment for a range of neurological disorders" 05/15/2005 - "Recent successes in treating neurological disorders with electrical stimulation of the brain have spurred interest in studying the neuronal mechanisms by which such therapies work" Get all the results and reference details, order at left...
140 Therapies and Procedures and 454 more articles analyzed in the Full Patient-Physician Summary Report, order at left...

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