Peripheral Nervous System Diseases (PNS Diseases)

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3461 relevant articles (178 outcomes, 365 trials/studies) found for this Disease

Description: Diseases of the peripheral nerves external to the brain and spinal cord, which includes diseases of the nerve roots, ganglia, plexi, autonomic nerves, sensory nerves, and motor nerves.

Also Known As:

PNS Diseases; Peripheral Neuropathy; Neuropathy, Peripheral; Peripheral Neuropathies; PNS (Peripheral Nervous System) Diseases; Peripheral Nervous System Disease; Peripheral Nervous System Disorders; Nerve Disease, Peripheral; Nerve Diseases, Peripheral; PNS Disease; Peripheral Nerve Disease; Peripheral Nerve Diseases

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Pain (Aches)
2.	Postherpetic Neuralgia
3.	Neoplasms (Cancer)
4.	Seizures (Seizure)
5.	Arthralgia (Joint Pain)

Experts

1.	Argyriou, Andreas A: 8 articles (09/2008 - 08/2005)
2.	Bennett, Gary J: 8 articles (07/2008 - 05/2004)
3.	Chroni, Elisabeth: 8 articles (11/2007 - 08/2005)
4.	Iconomou, Gregoris: 7 articles (09/2008 - 08/2005)
5.	Kalofonos, Haralabos P: 7 articles (09/2008 - 08/2005)
6.	Polychronopoulos, Panagiotis: 7 articles (11/2007 - 08/2005)
7.	Koutras, Angelos: 6 articles (01/2007 - 08/2005)
8.	Cavaletti, Guido: 5 articles (03/2008 - 07/2005)
9.	Levine, J D: 5 articles (03/2007 - 09/2000)
10.	Flatters, Sarah J L: 4 articles (03/2008 - 05/2004)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Peripheral Nervous System Diseases:

1.	pregabalin (Lyrica)FDA Link 07/01/2008 - "Efficacy, safety, and tolerability of pregabalin treatment for painful diabetic peripheral neuropathy: findings from seven randomized, controlled trials across a range of doses." 01/01/2008 - "Efficacy and safety of pregabalin 600 mg/d for treating painful diabetic peripheral neuropathy: a double-blind placebo-controlled trial." 04/01/2005 - "Relief of painful diabetic peripheral neuropathy with pregabalin: a randomized, placebo-controlled trial." 08/01/2004 - "Pregabalin for the treatment of painful diabetic peripheral neuropathy: a double-blind, placebo-controlled trial." 01/01/2009 - "Pregabalin for painful diabetic peripheral neuropathy." Order ALL the reference details at left...
2.	Paclitaxel (Taxol)FDA LinkGeneric 01/01/2008 - "Peripheral neuropathy (PN) is one of the most common and dose-limiting side effects of paclitaxel, a chemiotherapeutic drug of proven efficacy in various tumours. " 11/01/2008 - "The present studies were conducted to evaluate the efficacy of cannabinoid CB(2) receptor activation in suppressing painful peripheral neuropathy evoked by chemotherapeutic treatment with the antitumor agent paclitaxel. " 01/01/2008 - "Peripheral neuropathy due to paclitaxel: study of the temporal relationships between the therapeutic schedule and the clinical quantitative score (QST) and comparison with neurophysiological findings." 06/01/2006 - "Using a rat model of paclitaxel-induced painful peripheral neuropathy, we have performed studies to search for peripheral nerve pathology. " 06/01/2006 - "Studies of peripheral sensory nerves in paclitaxel-induced painful peripheral neuropathy: evidence for mitochondrial dysfunction." Order ALL the reference details at left...
3.	NAD (NADH)IBA 09/01/2009 - "OBJECTIVE: The purpose of this systematic review is to evaluate current evidence in the literature on the efficacy of Semmes Weinstein monofilament examination (SWME) in diagnosing diabetic peripheral neuropathy (DPN). " 07/01/2009 - "AIMS/HYPOTHESIS: The aim of the study was to determine whether diabetic peripheral neuropathy (DPN) is a risk factor for depressive symptoms and examine the potential mechanisms for this relationship. " 11/01/2008 - "This study (Part 2) defines the psychometric properties of the German-translated Norfolk QOL-DN in a large multicenter (96 sites) population with neuropathy ranging from minimal to severe, comparing them with those in the original English/American version in a 30-center European/North American population with mild neuropathy; determines the power of the German-translated version in a five-staged diabetic peripheral neuropathy (DPN) German population to discriminate different levels of neuropathy severity; and establishes factors having the greatest impact on QOL. " 09/01/2007 - "AIMS: The objective of this study was to describe the proportion and characteristics of patients with type 1 and type 2 diabetes diagnosed with diabetic peripheral neuropathy (DPN) in France, Italy, Spain, and the United Kingdom (UK). " 01/01/2005 - "Anterior-Posterior Centers-of-Pressure (AP CoP) were compared among the detected and non-detected trials for the Healthy Elderly Adults (HEA) and Diabetic Peripheral Neuropathy (DPN) elderly adults. " Order ALL the reference details at left...
4.	gabapentin (Neurontin)FDA LinkGeneric 09/30/2004 - "In the present study, we investigated the effect of gabapentin on mechanical, warm and cold allodynia in a rat model of peripheral neuropathy. " 08/01/2003 - "The aim of the present study was to investigate the effect of gabapentin in a recently developed mouse model of peripheral neuropathy. " 02/01/2009 - "Gabapentin extended release for the treatment of painful diabetic peripheral neuropathy: efficacy and tolerability in a double-blind, randomized, controlled clinical trial." 11/01/2007 - "BACKGROUND: The antiepileptic agent, gabapentin, has been demonstrated to relieve symptoms of peripheral neuropathy due to various etiologies. " 09/30/2004 - "Our results suggest that gabapentin is an effective agent against mechanical, warm and cold allodynia in a rat model of peripheral neuropathy." Order ALL the reference details at left...
5.	Amitriptyline (Elavil)FDA LinkGeneric 01/01/1995 - "The growing medical interest in acupuncture is evidenced in the progress of CPCRA 022, a phase II/III trial to study acupuncture alone or in combination with amitriptyline, an anti-depressant, as a treatment for peripheral neuropathy. " 08/01/1998 - "RESEARCH DESIGN AND METHODS: Patients (n = 26) with peripheral neuropathy were treated with amitriptyline. " 03/01/1997 - "Peripheral neuropathy in scleroderma successfully treated with amitriptyline." 02/01/1988 - "Amitriptyline-related peripheral neuropathy. " 10/01/1985 - "Peripheral neuropathy following amitriptyline overdose." Order ALL the reference details at left...
6.	Cisplatin (Platino)FDA LinkGeneric 01/01/1996 - "Although vigorous hydration schedules have helped to alleviate nephrotoxicity, ototoxicity and cumulative dose-related peripheral neuropathy, these side effects remain important dose-limiting toxicities related to cisplatin therapy. " 05/01/1992 - "Our study confirmed in this highly specific clinical model the existence of cisplatin peripheral neuropathy: we observed definite clinical signs or symptoms of neuropathy in 80% of patients receiving a cumulative cisplatin dosage of 675 mg/m2; there was a progressive dose-related decrease in SAP amplitudes, expression of a sensory axonopathy or neuronopathy." 02/01/1986 - "[Peripheral neuropathies during treatment with cisplatin: clinical and electrophysiologic study of 11 cases]" 08/01/2008 - "These results strongly support the notion that Ape1 is a potential translational target such that protecting Ape1 levels and particularly its DNA repair function could reduce peripheral neuropathy in patients undergoing cisplatin treatment." 08/01/2008 - "Peripheral neuropathy is one of the major side effects of the anticancer drug cisplatin. " Order ALL the reference details at left...
7.	Aldehyde Reductase (Aldose Reductase)IBA 03/01/2005 - "Although aldose reductase inhibitors (ARIs) have been shown to be effective against diabetic peripheral neuropathy, their effectiveness on diabetic digestive neuropathy remains to be evaluated. " 01/01/2000 - "OBJECTIVES: To assess the efficacy of aldose reductase inhibitors in the prevention, reversal or delay in the progression of diabetic peripheral neuropathy. " 01/01/1996 - "OBJECTIVES: To assess the efficacy of aldose reductase inhibitors in the prevention, reversal or delay in the progression of diabetic peripheral neuropathy. " 12/01/1996 - "A meta-analysis of trials on aldose reductase inhibitors in diabetic peripheral neuropathy. " 09/01/2007 - "Oral aldose reductase inhibitors have been studied with some success only in patients with diabetic peripheral neuropathy. " Order ALL the reference details at left...
8.	Immunoglobulin M (IgM)IBA 01/01/1985 - "Peripheral neuropathy in IgM kappa paraproteinaemia: clinical and ultrastructural studies in two patients." 12/01/2005 - "Peripheral neuropathy associated with IgM monoclonal gammopathy of unknown significance is a common disorder, while the association of paraproteinaemic neuropathies with haematological malignancies is far less frequent. " 10/14/2000 - "The association with peripheral neuropathy and IgM monoclonal gammapathy is well known. " 08/01/2000 - "Monoclonal IgM autoantibody reactivity in M-IgM peripheral neuropathy." 05/01/1999 - "BACKGROUND: The peripheral neuropathy associated with IgM paraproteinaemia usually runs a chronic, slowly progressive course which may eventually cause severe disability. " Order ALL the reference details at left...
9.	Thalidomide (Thalomid)FDA Link 08/01/2008 - "We report a patient with scleromyxoedema and peripheral neuropathy treated successfully with thalidomide. " 01/01/2007 - "Because thalidomide may cause peripheral neuropathy, it is current practice to perform nerve conduction studies to exclude subclinical neuropathy before treatment. " 02/01/2005 - "Children treated with thalidomide should undergo regular neurophysiologic studies in order to detect presymptomatic or progressive peripheral neuropathy." 11/01/2000 - "In contrast to humans, Beagle dogs did not develop thalidomide-induced peripheral neuropathy under conditions of the study." 09/01/1999 - "Our experience with low-dose, long-term thalidomide therapy suggests that peripheral neuropathy is not as common as suggested by other studies (up to 50% of patients treated with thalidomide in some series)." Order ALL the reference details at left...
10.	lamotrigine (Lamictal)FDA LinkGeneric 06/15/2008 - "Efficacy of lamotrigine in the management of chemotherapy-induced peripheral neuropathy: a phase 3 randomized, double-blind, placebo-controlled trial, N01C3." 09/01/1999 - "Efficacy of lamotrigine on sensory symptoms and pain in peripheral neuropathies." 06/15/2008 - "Based on such data, a multicenter double-blind, placebo-controlled, randomized trial was conducted to evaluate the effect of lamotrigine on pain and other neuropathic symptoms due to chemotherapy-induced peripheral neuropathy (CIPN). " 01/01/2002 - "Lamotrigine, a new anticonvulsant, is effective in trigeminal neuralgia, painful peripheral neuropathy, and post-stroke pain. " 04/01/2007 - "AIMS: To compare the efficacy and safety of lamotrigine and amitriptyline in controlling chronic painful peripheral neuropathy in diabetic patients. " Order ALL the reference details at left...

Therapies and Procedures

1.	Drug Therapy (Chemotherapy) 01/01/2007 - "ALC has demonstrated efficacy and high tolerability in the treatment of neuropathies of various aetiologies, including chemotherapy-induced peripheral neuropathy (CIPN). " 01/01/2009 - "Additionally Gosya-jinki-gan might be more effective for peripheral neuropathy when it is administered from the beginning of chemotherapy including PTX." 02/01/1984 - "Peripheral neuropathy in osteosclerotic myeloma: clinical and electrodiagnostic improvement with chemotherapy." 12/01/2009 - "GOALS: The aim of the study was to determine the feasibility and validity of a newly developed patient-based instrument--the Patient Neurotoxicity Questionnaire (PNQ)--for grading chemotherapy-induced peripheral neuropathy (CIPN). " 06/01/2009 - "CI-PERINOMS: chemotherapy-induced peripheral neuropathy outcome measures study." Order ALL the reference details at left...
2.	Injections 01/01/1991 - "15% of the patients treated with Eta plus radiotherapy have received less than 15 Eta injections, mainly because of skin rashes (5%), peripheral neuropathies (3%) or patient refusal (3%). " 01/01/1976 - "injections of acrylamide (15 mg/kg) daily for 10 days to induce a peripheral neuropathy. " 12/01/2006 - "In the present study, we evaluated the efficacy of BoNT/A injections into the CP muscle in diabetic patients with severe oropharyngeal dysphagia associated with diabetic autonomic and/or somatic peripheral neuropathy. " 04/01/1995 - "The use of nonsteroidal anti- inflammatory drugs, opiates, alternative routes of administration, the treatment of peripheral neuropathy and aphthous ulcers, and the problem of pain resulting from repeated injections are also examined. " 12/01/1987 - "In 2 patients SEPs showed a marked improvement following treatment with vitamin B12 injections, one consistent with restored central conduction and the other with recovery from peripheral neuropathy. " Order ALL the reference details at left...
3.	Plasma Exchange 08/01/1984 - "Plasma exchange treatment of peripheral neuropathy associated with plasma cell dyscrasia." 02/01/1994 - "It is concluded that in peripheral neuropathy associated with MGUS selective techniques of apheresis can prove useful both in obtaining positive results and in avoiding the collateral effect of the original plasma exchange." 04/01/1986 - "Patients with rapidly progressive renal failure or active and reversible lesions generally improved after plasma-exchange, as well as those with a recently occurring sensory-motor peripheral neuropathy. " 04/01/1996 - "Plasma exchange was followed by disappearance of clinical and electrophysiological signs of neuromyotonia and MG, as well as peripheral neuropathy." 01/01/1994 - "Long-term plasma exchange was prescribed to 38 patients who failed to respond to conventional therapy; cryoglobulinemias, peripheral neuropathies and monoclonal gammopathies were their most frequent underlying diseases. " Order ALL the reference details at left...
4.	Immunotherapy 01/01/2006 - "SELECTION CRITERIA: We included randomised or quasi-randomised controlled trials of participants of any age treated with any type of immunotherapy for anti-myelin-associated glycoprotein antibody associated demyelinating peripheral neuropathy with monoclonal gammopathy of undetermined significance of any severity. " 01/01/2006 - "OBJECTIVES: To examine the efficacy of any form of immunotherapy in reducing disability and impairment resulting from IgM anti-myelin associated glycoprotein paraprotein-associated demyelinating peripheral neuropathy. " 01/01/2003 - "OBJECTIVES: To examine the efficacy of any form of immunotherapy in reducing disability and impairment resulting from IgM anti-Myelin Associated Glycoprotein paraprotein-associated demyelinating peripheral neuropathy. " 01/01/2006 - "Immunotherapy for IgM anti-myelin-associated glycoprotein paraprotein-associated peripheral neuropathies." 01/01/2003 - "Immunotherapy for IgM anti-Myelin-Associated Glycoprotein paraprotein-associated peripheral neuropathies." Order ALL the reference details at left...
5.	Aftercare (After-Treatment) 08/01/2005 - "RESULTS: The effective rate was 85.71% in the group III, 76.47% in the group II and 56.25% in the group I; after treatment MCV and SCV improved significantly in the group III. CONCLUSION: The basic treatment plus tapping with plum-blossom needle has a better therapeutic effect on diabetic peripheral neuropathies." 07/01/2004 - "SUBJECTS: Sixty-eight individuals over age 64 with diabetes, diabetic peripheral neuropathy, and loss of protective sensation who had clinically demonstrable increases in foot sensation to the Semmes-Weinstein monofilament after treatment with monochromatic near infrared photo energy. " 04/01/1999 - "CONCLUSIONS: Although it has been reported that peripheral neuropathy occurred after treatment with PHT for a week, there has been no report of a patient such as ours, who developed peripheral neuropathy just a few hours after the initial administration of PHT. " 01/01/1980 - "Peripheral neuropathy and ophthalmologic toxicity after treatment with cis-dichlorodiaminoplatinum II." 03/01/2006 - "Improved foot sensitivity and pain reduction in patients with peripheral neuropathy after treatment with monochromatic infrared photo energy--MIRE." Order ALL the reference details at left...

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