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Messenger RNA (mRNA)

RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Also Known As:
mRNA; Poly(A) Tail; RNA, Messenger; Non-Polyadenylated mRNA; Poly(A) RNA; Polyadenylated mRNA; Non Polyadenylated mRNA; Polyadenylated Messenger RNA; Polyadenylated RNA; RNA, Polyadenylated Messenger; mRNA, Non Polyadenylated; Messenger RNA, Polyadenylated; Poly(A)+ RNA; Poly(A)+ mRNA; RNA, Messenger, Polyadenylated; RNA, Polyadenylated; mRNA, Non-Polyadenylated; mRNA, Polyadenylated
Networked: 115441 relevant articles (2212 outcomes, 11779 trials/studies)

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Bio-Agent Context: Research Results

Experts

1. Zhang, Wei: 264 articles (06/2022 - 06/2003)
2. Wang, Wei: 240 articles (11/2022 - 02/2002)
3. Wang, Yan: 173 articles (06/2022 - 01/2005)
4. Wang, Jing: 169 articles (12/2022 - 03/2004)
5. Li, Li: 164 articles (08/2022 - 04/2002)
6. Liu, Yang: 159 articles (05/2022 - 02/2002)
7. Li, Wei: 152 articles (11/2022 - 02/2003)
8. Zhang, Jing: 146 articles (07/2022 - 04/2002)
9. Li, Yan: 143 articles (07/2022 - 05/2003)
10. Li, Jun: 141 articles (09/2022 - 11/2002)

Related Diseases

1. Neoplasms (Cancer)
2. Infections
3. COVID-19
4. Inflammation (Inflammations)
5. Body Weight (Weight, Body)
08/01/2000 - "Marked changes in the CAIII levels of liver cytosol were observed in rats following doses of PenCB ranging from 0.5 to 25 mg/kg body weight and maximum suppression was observed at a dose of 10 mg/kg. Northern analysis revealed that the level of CAIII mRNA in rat liver was dramatically reduced by PenCB treatment while only weak suppression was observed in pair-fed controls. "
08/01/2000 - "However, there was no difference in muscle UCP3/actin mRNA ratios between DIO animals and DR animals that had been fed the HE diet for 10 weeks and then returned to either an ad libitum chow diet for 10 weeks (DIO = 13.8 +/- 3.53, DR = 11.1 +/- 3.43, p = NS) or to a restricted chow diet for 10 weeks (DIO = 11.0 +/- 2.85, DR = 10.6 +/- 2.20, p = NS) despite significantly greater body weight of the DIO animals. "
06/01/2008 - "Since pair feeding of the high-fat diet eliminated both the body weight and CART mRNA differences between the DIO and DR mice, it is likely that their alterations in gene expression were a consequence of their dissimilar body weight levels."
01/03/2023 - "This study investigates intramuscular (IM) adipocyte development in the Longissimus muscle (LM) between Wagyu- and Angus-sired steers compared at a similar age and days on feed (D) or similar body weight (B) endpoint by measuring IM adipocyte cell area and lipid metabolism mRNA expression. "
01/03/2023 - "This study investigates intramuscular (IM) adipocyte development in the Longissimus muscle (LM) between Wagyu- and Angus-sired steers compared at a similar age and days on feed (D) endpoint or similar body weight (B) endpoint by measuring IM adipocyte cell area and lipid metabolism mRNA expression. "

Related Drugs and Biologics

1. Proteins (Proteins, Gene)
2. Vaccines
3. Cytokines
4. Messenger RNA (mRNA)
5. Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
6. Interleukin-6 (Interleukin 6)
7. COVID-19 Vaccines
8. Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
9. Interleukin-10 (Interleukin 10)
10. Small Interfering RNA (siRNA)

Related Therapies and Procedures

1. Therapeutics
2. Drug Therapy (Chemotherapy)
3. Immunotherapy
4. Aftercare (After-Treatment)
5. Oral Administration