Abstract | Objectives: The present study aimed to assess the efficacy of some known extracts on learning and memory impairment induced by streptozocin (STZ) in male rats. Materials and Methods: Eighty male rats were randomly divided: 1) control, 2) STZ (50 mg/kg), 3) STZ+Trigonella foenum-graecum (200 mg/kg), 4) STZ+Ribes rubrum (500 mg/kg), 5) STZ+Lavandula angustifolia (400 mg/kg), 6) STZ+Arctium Lappa (200 mg/kg), 7) STZ+mix of extracts (quarter dose of each extract), and 8) STZ+metformin (100 mg/kg). Treatment was continued for 8 weeks and the after that, the behavioral tests related to learning and memory including Morris water maze (MWM) and passive avoidance (PA) were performed along with biochemical analysis associated with oxidative stress pathway and other related indicators. Results: Conclusion: The present study demonstrated these extracts alone or in combination with a minimum dose have a strong potential to ameliorate learning and memory impairment induced by STZ along with lowering glucose levels by which they prevent or manage diabetes. It is noteworthy that the results matched those of metformin a well-known anti-diabetic drug.
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Authors | Mona Sadat Hosseini Arya, Samaneh Kakhki, Farimah Beheshti, Mohammad Hadi Ebrahimzadeh, Jalil Farzadmehr |
Journal | Iranian journal of basic medical sciences
(Iran J Basic Med Sci)
Vol. 26
Issue 12
Pg. 1490-1497
( 2023)
ISSN: 2008-3866 [Print] Iran |
PMID | 37970441
(Publication Type: Journal Article)
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