Reduction of obesity and hepatic adiposity in high-fat diet-induced rats by besunyen slimming tea.

Abstract

Objective:

Obesity is a significant risk factor for metabolic syndrome, type 2 diabetes mellitus, hypertension, nonalcoholic fatty liver disease, and cardiovascular disorders. As a well-known Chinese tea product, Besunyen Slimming Tea (BST) is believed to effectively reduce body weight (BW) and lipid profile. In this study, we aimed to elucidate the mechanisms and effects of BST on treating obesity and hepatic steatosis using a rat model fed with a high-fat diet (HFD).

Methods:

Sprague-Dawley rats were subjected to random separation into three categories: Animals were fed (1) a normal diet food (ND); (2) HFD, and (3) HFD + BST (n = 12/category). After successfully establishing the obesity model at week 8, the HFD + BST received BST (0.6 g/0.6 kg) orally, and the ND and HFD received the same amount (2 ml) of distilled water orally.

Results:

HFD + BST reduced waist circumference (7.84%, P = 0.015), food intake (14.66%, P = 0.011), final BW (12.73%, P = 0.010), BW gain (964.16%, P < 0.001), and body mass index (8.97%, P = 0.044) compared with the HFD. BST supplementation also decreased hyperlipidemia, inflammation, and insulin resistance in rats with HFD. Furthermore, BST suppressed hepatic lipidosis by decreasing de novo lipogenesis and increasing fatty acid oxidation.

Conclusions:

The results of this study offer evidence supporting the potential health benefits of BST in the management of metabolic disorders and obesity.

• Authors: Chingwen Yu, Xiaoning Wan, Dan Li, Xiaomei Guo
• Journal: Heliyon (Heliyon) Vol. 9 Issue 6 Pg. e17383 (Jun 2023) ISSN: 2405-8440 [Print] England
• PMID: 37416691 (Publication Type: Journal Article)
• Copyright: © 2023 The Authors.