Abstract | OBJECTIVE: METHODS: RESULTS: PCPA injection significantly decreased sleep duration, increased sleep latency and induced anxiety-like behaviors in mice. In PCPA-insulted mice, EA of the cymba concha improved the sleep disturbance by significantly prolonging sleep duration, while no change in sleep latency was observed. Moreover, EA of the cymba concha improved PCPA-induced anxiety-like behaviors without decreasing locomotor activities in the open field test. EA of the cymba concha increased the level of GABA in the hypothalamus and peripheral blood, while Glu concentrations remained unchanged. CONCLUSION: These findings indicate that EA of the region innervated by the ABVN upregulates GABA levels in the hypothalamus and ameliorates the symptoms of insomnia and anxiety, suggesting that EA of the cymba concha might have potential value as an intervention for insomnia.
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Authors | Fenyan Zhang, Xiaoming Zhang, Qi Peng, Ling Tang |
Journal | Acupuncture in medicine : journal of the British Medical Acupuncture Society
(Acupunct Med)
Vol. 41
Issue 6
Pg. 345-353
(12 2023)
ISSN: 1759-9873 [Electronic] England |
PMID | 37081732
(Publication Type: Journal Article)
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Chemical References |
- Fenclonine
- gamma-Aminobutyric Acid
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Topics |
- Mice
- Animals
- Sleep Initiation and Maintenance Disorders
(chemically induced, therapy)
- Fenclonine
- Electroacupuncture
- Hypothalamus
- gamma-Aminobutyric Acid
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