Hypnotics and Sedatives (Sedatives)

05/01/2015 - "The present study suggested that usage of multiple hypnotics is not beneficial for relieving insomnia or for keeping better QOL in shift work nurses. "
11/01/2002 - "Good evidence exists for the efficacy of hypnotics for short term insomnia but long term data is currently lacking. "
01/01/1993 - "More than half of the patients reported a daily use of the hypnotics for 1-5 years or longer, but only 22% of the severely insomniac patients reported at the time of the third inquiry a significant improvement of insomnia due to the administration of sleeping pills. "
11/01/2006 - "Cognitive-behavioral treatment (CBT) has been found to be just as effective as hypnotics for the treatment of acute insomnia and more effective for the treatment of chronic insomnia. "
12/01/2004 - "There is now an overwhelming preponderance of evidence that cognitive behavioural therapy for insomnia (CBT-I) is effective, as effective as sedative hypnotics during acute treatment (4-8 weeks), and is more effective in long term (following treatment). "

01/01/2011 - "For example, what medications can be used safely to treat pain, what sedatives are safe and effective, which medications are to be avoided, what diet should be prescribed, and which invasive procedures are safe. "
01/01/2013 - "Understanding the underlying fundamental mechanics behind insertion difficulties and pain during colonoscopy may help to simplify colonoscopy and reduce the required extent of training and reliance on sedatives. "
06/01/2002 - "They should include assessment of general behaviour, locomotor activity and motor coordination, but can also include studies of pain sensitivity, convulsive threshold and interaction with hypnotics. "
01/01/1994 - "This survey concerned the patient's general status, his usual sleep profile and factors which could interfere with sleep (hypnotics, pain, environmental factors) throughout the study period. "
01/01/2016 - "Although our initial results suggest that a proposed framework consisting of self-treatment and recreational motives might have some utility in explaining the use of stimulants and pain relievers, more research is needed to characterize motives for tranquilizers and sedatives. "

04/01/2014 - "Since hypnotics are traditionally associated with misuse, a lack of abuse liability of DORAs would offer significant benefits over current therapies for sleep disorders. "
09/01/2015 - "A total of 45,602 patients with nonapnea sleep disorders and use of hypnotics were identified as the study cohort. "
09/01/2015 - "Risk of Type 2 Diabetes in Patients With Nonapnea Sleep Disorders in Using Different Types of Hypnotics: A Population-Based Retrospective Cohort Study."
06/01/2015 - "The safety and efficacy data of hypnotics for primary sleep disorders are limited in pediatrics and should be avoided or used with extreme caution in children with comorbid sleep and psychiatric problems. "
12/14/2011 - "Since developing hypnotics that increase NREMS without altering sleep architecture remains a medical challenge, MT(2) receptors may represent a novel target for the treatment of sleep disorders."

01/01/2015 - "To assess the safety and efficacy of alpha-2 agonists for sedation of more than 24 hours, compared with traditional sedatives, in mechanically-ventilated critically ill patients. "
02/01/2014 - "To study the feasibility of daily interruption of sedatives in critically ill children. "
11/01/1994 - "We have shown that it is possible to prospectively study the toxicity of sedatives in critically ill infants and children."
04/01/2014 - "Alterations in end-organ function in critically ill patients may also lead to varied responses to commonly used sedatives. "
02/01/2014 - "Randomized controlled trial of daily interruption of sedatives in critically ill children."

08/01/2015 - "Z-drugs have improved pharmacokinetic profiles, but incidence of neuropsychiatric sequelae, poisoning, and death may prove to be similar to the other hypnotics. "
06/01/2013 - "Though Z-drugs have improved pharmacokinetic profiles, their adverse effects, neuropsychiatric sequelae, and incidence of poisoning and death may prove to be similar to older hypnotics."
04/29/1961 - "[Experimental studies on the treatment of severe poisoning by sedatives with the artifical kidney]."
08/01/2014 - "In 108,265 patients, the most common causes of poisoning were anti-epileptics and sedative-hypnotics (22.3%). "
04/01/2009 - "Multi target analysis of putrefactive specimens by liquid chromatography-tandem mass spectrometry to prove multiple poisonings by hypnotics and muscle relaxants."