Serum netrin-1 and netrin receptor levels in fibromyalgia and osteoarthritis.

Abstract

Objectives:

This study aims to define serum levels of netrin-1 and netrin receptors in patients with fibromyalgia (FM) and osteoarthritis (OA).

Patients and methods:

This cross-sectional study was conducted with a total of 150 female participants (mean age: 47.2±16.1 years; range, 18 to 89 years) at Fırat University between June 2016 and December 2016. The participants were evaluated in three groups: the FM group with 50 patients, the OA group with 50 patients, and the control group, which included 50 healthy volunteers. Netrin-1, netrin receptors (DCC, UNC5B, and UNC5D), interleukin (IL)-6, IL-10, and IL-17 levels were analyzed by the enzyme-linked immunosorbent assay from the serum samples of the participants.

Results:

The level of serum netrin-1 was significantly lower in the FM group than in the control and OA groups (p<0.01 and p<0.001, respectively). However, the difference between patients with OA and healthy controls in terms of netrin-1 was not statistically significant (p>0.05). In addition, serum levels of netrin receptors and cytokines in the FM group were similar to the control group (p>0.05). However, serum DCC, UNC5D, IL-6, and IL-10 levels were higher in the OA group compared to the control group (p<0.001, p<0.05, p<0.01, and p<0.001, respectively).

Conclusion:

Serum netrin-1 level is suppressed in FM, which suggests that netrin-1 is influential in FM pathogenesis.

• Authors: Alparslan Köhle, Arif Gülkesen, Tuba Kaya Karataş, Gürkan Akgöl, Ahmet Karataş, Necip İlhan, Süleyman Serdar Koca
• Journal: Turkish journal of physical medicine and rehabilitation (Turk J Phys Med Rehabil) Vol. 68 Issue 2 Pg. 238-245 (Jun 2022) ISSN: 2587-1250 [Electronic] Turkey
• PMID: 35989959 (Publication Type: Journal Article)
• Copyright: Copyright © 2022, Turkish Society of Physical Medicine and Rehabilitation.