Innate immunity is the only defense system for resistance against
infections in crustaceans. In crustaceans, white spot diseases caused by white spot syndrome virus (WSSV) are a serious
viral disease with high accumulative mortality after
infection. Attachment and entry into cells have been known to be two initial and important steps in
viral infection. However, systematic information about the mechanisms related to WSSV
infection in crustaceans is still limited. Previous studies have reported that cellular receptors are important in the innate immune system and are responsible for the recognition of foreign microorganisms and in the stimulation of the immune responses during
infections. In this review, we summarize the current understanding of the functions of cellular receptors, including Toll,
C-type lectin,
scavenger receptor, β-
integrin,
polymeric immunoglobulin receptor,
laminin receptor, globular
C1q receptor,
lipopolysaccharide-and β-1,3-glucan-binding
protein,
chitin-
binding protein, Ras-associated binding, and
Down syndrome cell adhesion molecule in the innate immune defense of crustaceans, especially shrimp and crabs, in response to WSSV
infection. The results of this study provide information on the interaction between viruses and hosts during
infections, which is important in the development of preventative strategies and
antiviral targets in cultured aquatic animals.