Drug-eluting stents (DESs) placement remarkably reduces the over-proliferation of smooth muscle cells (SMCs) and thus neointimal
hyperplasia. However, the pharmacological agent also slows down the re-endothelization, delays
injury vascular healing and increases the risk of in-
stent restenosis (ISR). Here, inspired by mussel foot
proteins (Mfps), a mimicking endothelium functional
stent coating was efficiently fabricated by
thiol-ene "click" reaction, consisting of
catechol grafted
chitosan (CS-C),
zinc sulfate, and
Arg-Glu-Asp-Val (REDV)
peptide. The mimicking endothelium coating could continuously catalyze endogenous
nitric oxide (NO) gas and maintain the bioactivity of REDV
peptide. Compared with bare
stents, the mimicking coatings significantly inhibited the acute
thrombosis for the first 1-week, accelerated re-endothelization and decreased in-
stent restenosis for 1- and 3-month after implantation. In addition, the synergistic effect of NO and REDV
peptide also regulated
inflammation response and promoted the expression of muscle fiber.