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Drug-Eluting Stents

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Stents that are covered with materials that are embedded with chemicals that are gradually released into the surrounding milieu.

Also Known As:

Drug Coated Stents; Drug Eluting Stents; Drug-Coated Stent; Drug-Eluting Stent; Stent, Drug-Coated; Stent, Drug-Eluting; Stents, Drug Coated; Stents, Drug Eluting; Drug-Coated Stents; Stents, Drug-Coated; Stents, Drug-Eluting

Networked: 2732 relevant articles (209 outcomes, 445 trials/studies)

Relationship Network

Therapy Context: Research Results

Equipment and Supplies
- Prostheses and Implants: 13222
  - Stents: 31330
    - Drug-Eluting Stents: 2732

Experts

1.	Serruys, Patrick W: 85 articles (12/2015 - 03/2002)
2.	Park, Seung-Jung: 77 articles (10/2015 - 01/2005)
3.	Kim, Young-Hak: 62 articles (10/2015 - 11/2005)
4.	Waksman, Ron: 61 articles (10/2015 - 01/2004)
5.	Stone, Gregg W: 59 articles (12/2015 - 03/2005)
6.	Park, Seong-Wook: 55 articles (10/2015 - 01/2005)
7.	Colombo, Antonio: 50 articles (12/2014 - 04/2002)
8.	Hong, Myeong-Ki: 48 articles (01/2016 - 01/2005)
9.	Lee, Cheol Whan: 48 articles (10/2015 - 01/2005)
10.	Park, Duk-Woo: 48 articles (10/2015 - 11/2005)

Related Diseases

1.	Coronary Artery Disease (Coronary Atherosclerosis) 01/01/2011 - "Most available data indicates that stenting for unprotected left main coronary artery disease (ULMCA) with drug-eluting stents (DES) is safe and effective. " 02/07/2007 - "Although full metal jacket using drug-eluting stent (DES) for a single coronary artery disease has sparsely been described before, there is no report of safety and efficacy of complete metal jacket from left main (LM) to three major coronary arteries. " 08/01/2006 - "Drug-eluting stents have been shown to be very effective in the treatment of coronary artery disease. " 04/01/2006 - "In coronary artery disease, although drug eluting stents have improved the results of percutaneous coronary intervention, coronary artery bypass grafts have still has an important place in the treatment of severe lesions: multivessel disease, left main and diabetes. " 06/01/2015 - "Drug-eluting stents have significantly improved the treatment of coronary artery disease. "
2.	Thrombosis (Thrombus) 01/01/2015 - "The introduction of drug-eluting stents (DES) has dramatically reduced restenosis rates compared with bare metal stents, but in-stent thrombosis remains a safety concern, necessitating prolonged dual anti-platelet therapy. " 08/01/2013 - "Although drug-eluting stents have dramatically reduced angiographic restenosis and clinical need for repeat revascularization procedures, some adverse effects, such as late stent thrombosis, have been described. " 11/01/2012 - "Drug-eluting stents have dramatically reduced the risk of restenosis, but concerns of an increased risk of stent thrombosis have provided uncertainty about their use. " 08/01/2012 - "Deployment of drug-eluting stents instead of bare-metal stents has dramatically reduced restenosis rates, but rates of very late stent thrombosis (>1 year postimplantation) have increased. " 07/01/2010 - "Drug-eluting stents (DES) are highly effective in reducing restenosis but have a small but significant risk for late stent thrombosis (LAST). "
3.	Myocardial Infarction 04/01/2008 - "Drug-eluting stents (DES) have proven to be effective in reducing the rate of restenosis and have, therefore, been incorporated into the treatment of patients with ST-elevation acute myocardial infarction (STEMI). " 12/07/2014 - "In the FAME 2 trial, fractional flow reserve-guided percutaneous coronary intervention with second generation drug eluting stents showed a significant reduction in the primary composite endpoint of 2-year mortality, myocardial infarction and unplanned hospitalization with urgent revascularisation as compared to medical therapy alone. " 06/01/2010 - "Drug-eluting stents are associated with a significant reduction in the 3-year cumulative rates of all-cause mortality, cardiovascular death, and myocardial infarction when compared to BMS. " 03/01/2010 - "Early data suggest that drug eluting stents reduce restenosis rates and the need for repeat revascularization irrespective of the diabetic state and with no significant reduction in hard clinical endpoints such as myocardial infarction and mortality. " 03/03/2011 - "Meta-analysis of randomized trials showed superior efficacy and similar safety of drug-eluting stent over bare-metal stent in acute ST-elevation myocardial infarction (STEMI) patients. "
4.	Pathologic Constriction (Stenosis) 02/01/2007 - "In the era of drug-eluting stents that have dramatically reduced the re-stenosis rate, and in the context of the development of emerging modalities like magnetic resonance imaging (MRI) and multislice computed tomography that allow precise and non-invasive diagnosis, it becomes important to question whether and how fluoroscopic-based evaluation of cardiac structure and function shall evolve. " 08/01/2010 - "The degree of in-stent stenosis was significantly reduced in the SES group, suggesting that the use of drug-eluting stents is an effective treatment for PVS. " 02/01/2009 - "Urgent coronary angiography showed severe LMCA stenosis caused by extrinsic compression from the pulmonary artery with no other lesions in the coronary arteries; coronary angioplasty was successfully performed with a direct drug-eluting stent implantation that led to a significant improvement of the haemodynamic conditions in the following days. " 01/01/2005 - "With coronary revascularization, drug-eluting stents have significantly decreased the incidence of in-stent stenosis and, therefore, the morbidity of the procedure. " 12/01/2010 - "Drug-eluting stent implantation for unprotected LMCA stenosis appears safe with regard to acute and long-term complications and is more effective in preventing restenosis compared to BMS implantation."
5.	Coronary Disease (Coronary Heart Disease) 01/01/2010 - "CILON-T trial will give powerful insight into whether triple anti-platelet therapy is superior to dual anti-platelet therapy in reducing ischemic events and platelet reactivity in the real-world unselected patients treated with drug-eluting stent for coronary heart disease. " 12/01/2004 - "Drug-eluting stents may represent a major advance in the management of diabetic patients with coronary heart disease in the near future." 01/01/2011 - "Hybrid revascularisation, in two stages: first - minimally invasive direct coronary artery bypass grafting procedure with left internal mammary artery conduit to left anterior descending artery and second stage - percutaneus coronary intervention with drug eluting stent in non-left anterior descending vessels may be safe and effective alternative in patients with multivessel and left main coronary disease." 06/01/2006 - "Although coronary surgery is still considered the current, evidence-based, gold-standard treatment of left main (LM) and 3-vessel coronary disease, the added benefit of drug-eluting stents has further expanded the use of percutaneous coronary intervention (PCI) beyond less complex populations in daily practice. " 10/01/2006 - "In conclusion, full metal jacket drug-eluting stents may be a safe and effective method to treat diffuse coronary disease and may be a useful treatment option for complex long lesions."

Related Drugs and Biologics

1.	Polymers
2.	glucuronyl glucosamine glycan sulfate (Vessel)
3.	Paclitaxel (Taxol)
4.	Sirolimus (Rapamycin)
5.	clopidogrel (Plavix)
6.	Aspirin (Acetylsalicylic Acid)
7.	cilostazol (Pletal)
8.	omega-Chloroacetophenone (Mace)
9.	everolimus
10.	Heparin (Liquaemin)

Related Therapies and Procedures

1.	Stents
2.	Coronary Artery Bypass (Coronary Artery Bypass Surgery)
3.	Transplants (Transplant)
4.	Angioplasty (Angioplasty, Transluminal)
5.	Balloon Angioplasty