Fibroblast growth factor 21 (
FGF21) plays a role in
kidney disease. Circulating
FGF21 levels are associated with kidney function and progression in patients with
type 2 diabetes (T2D). However, the association between
FGF21 and kidney function in the general population is still lacking. The aim of this study was to determine the association between
FGF21 and kidney function and its progression in a Chinese cohort.A total of 2425 participants from a population-based survey of diabetes and
metabolic syndrome in Pinggu, Beijing, were included in the baseline analysis. After a median follow-up of 12 months, 2402 participants with baseline estimated glomerular filtration rate (eGFR) ≥60 mL/min/1.73 m2 were analyzed in the longitudinal study. The progression of kidney function was defined as an eGFR decline exceeding 3.3% per year. Serum
FGF21 levels were measured using an
enzyme-linked
immunosorbent assay at baseline.Male sex, body mass index (BMI), homeostasis model assessment of
insulin resistance, higher levels of
low-density lipoprotein cholesterol (
LDL-c),
uric acid, and
FGF21 were associated with increased odds of a lower eGFR at baseline. The association of
FGF21 with lower eGFR was independent of all the potential confounders in multivariable logistic regression (odds ratio, 1.005; 95% confidence interval 1.002-1.008). However,
FGF21 was not associated with eGFR decline in the longitudinal analysis (odds ratio, 1.000; 95% confidence interval 0.998-1.001).Increased serum
FGF21 levels were independently associated with lower eGFR in this nonmedicated general population.
FGF21 could be a
biomarker of kidney function in the general population.