Abstract | OBJECTIVE: Several species of Pinus have shown anti-nociceptive and anti-inflammatory properties. This study was aimed to evaluate anti-nociceptive and anti-inflammatory effects of hydroalcoholic extract of bark and essential oil of leaves of P. eldarica in animal models. MATERIALS AND METHODS: RESULTS: The total phenolic content of the extract in terms of gallic acid equivalent was 404.9±7.7 mg/g of the extract powder. P. eldarica hydroalcoholic extract (200 and 400 mg/kg) and essential oil (100 and 200 µl/kg) significantly (all, p<0.001) decreased pain behavior in acetic acid and formalin tests but not in hot plate test. The extract and essential oil suppressed edema in carrageenan and croton tests. Glibenclamide partially reversed the anti-nociceptive effect of hydroalcoholic extract while the other antagonists were ineffective. CONCLUSION: Hydroalcoholic extract of bark and essential oil of leaves of P. eldarica significantly decreased acute and chronic pain as well as inflammation. ATP-dependent K+ channels mediate a part of the observed anti-nociceptive effect.
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Authors | Valiollah Hajhashemi, Behzad Zolfaghari, Pooya Amin |
Journal | Avicenna journal of phytomedicine
(Avicenna J Phytomed)
2021 Sep-Oct
Vol. 11
Issue 5
Pg. 494-504
ISSN: 2228-7930 [Print] Iran |
PMID | 34745921
(Publication Type: Journal Article)
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