The nano delivery systems and applications of mRNA.

Abstract

The current COVID-19 epidemic has greatly accelerated the application of mRNA technology to our real world, and during this battle mRNA has proven it's unique advantages compared to traditional biopharmaceutical and vaccine technology. In order to overcome mRNA instability in human physiological environments, mRNA chemical modifications and nano delivery systems are two key factors for their in vivo applications. In this review, we would like to summarize the challenges for clinical translation of mRNA-based therapeutics, with an emphasis on recent advances in innovative materials and delivery strategies. The nano delivery systems include lipid delivery systems (lipid nanoparticles and liposomes), polymer complexes, micelles, cationic peptides and so on. The similarities and differences of lipid nanoparticles and liposomes are also discussed. In addition, this review also present the applications of mRNA to other areas than COVID-19 vaccine, such as infectious diseases, tumors, and cardiovascular disease, for which a variety of candidate vaccines or drugs have entered clinical trials. Furthermore, mRNA was found that it might be used to treat some genetic disease, overcome the immaturity of the immune system due to the small fetal size in utero, treat some neurological diseases that are difficult to be treated surgically, even be used in advancing the translation of iPSC technology et al. In short, mRNA has a wide range of applications, and its era has just begun.

• Authors: Mingyuan Li, Yuan Li, Shiqin Li, Lin Jia, Haomeng Wang, Meng Li, Jie Deng, Ali Zhu, Liqiao Ma, Weihong Li, Peng Yu, Tao Zhu
• Journal: European journal of medicinal chemistry (Eur J Med Chem) Vol. 227 Pg. 113910 (Jan 05 2022) ISSN: 1768-3254 [Electronic] France
• PMID: 34689071 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2021 Elsevier Masson SAS. All rights reserved.

Chemical References

• COVID-19 Vaccines
• Lipid Nanoparticles
• Liposomes
• Micelles
• Nanoparticle Drug Delivery System
• Peptides
• RNA, Messenger

Topics

• COVID-19 (prevention & control, virology)
• COVID-19 Vaccines (administration & dosage, chemistry)
• Humans
• Liposomes (chemistry)
• Micelles
• Nanoparticle Drug Delivery System (chemistry)
• Nanoparticles (chemistry)
• Peptides (chemistry)
• RNA, Messenger (chemistry, metabolism)
• SARS-CoV-2 (isolation & purification)