Micelles

Particles consisting of aggregates of molecules held loosely together by secondary bonds. The surface of micelles are usually comprised of amphiphatic compounds that are oriented in a way that minimizes the energy of interaction between the micelle and its environment. Liquids that contain large numbers of suspended micelles are referred to as EMULSIONS.

Networked: 1446 relevant articles (180 outcomes, 246 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Kataoka, Kazunori: 48 articles (01/2016 - 12/2003)
2.	Nishiyama, Nobuhiro: 38 articles (12/2015 - 12/2003)
3.	Torchilin, Vladimir P: 38 articles (04/2015 - 10/2002)
4.	Zhang, Qiang: 24 articles (09/2015 - 04/2009)
5.	Yuan, Hong: 23 articles (05/2015 - 08/2007)
6.	Du, Yong-Zhong: 23 articles (05/2015 - 08/2007)
7.	Hu, Fu-Qiang: 22 articles (05/2015 - 08/2007)
8.	Cabral, Horacio: 19 articles (12/2015 - 12/2003)
9.	Gao, Jinming: 19 articles (11/2015 - 08/2004)
10.	Hennink, Wim E: 18 articles (08/2015 - 03/2008)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2016 - "In fact polymeric micelles are among the most extensively studied delivery platforms for the effective treatment of different cancers as well as non-cancerous disorders. " 12/24/2014 - "However, following systemic delivery, the DOX-loaded micelles with the most hydrophobic core exhibited the most significant inhibition of tumor growth in a MDA-MB-231 tumor model, indicating the importance of hydrophobicity of core on the antitumor efficacy of drug delivery systems. " 06/01/2013 - "In vivo antitumor activity demonstrated that FA-hyd micelles had the highest safety to body and the best therapeutic efficacy to tumors. " 10/01/2009 - "These shell-sheddable biodegradable micelles are highly promising for the efficient intracellular delivery of various lipophilic anticancer drugs to achieve improved cancer therapy." 08/01/2009 - "To the best of our knowledge, our results demonstrated for the first time that polyplex micelles might show improved tumor penetrability over cationic polyplexes, thereby achieving transfection into the inside of the tumor tissue."
2.	Breast Neoplasms (Breast Cancer) 03/01/2015 - "The cumulative evidence indicates that Res-loaded mixed micelles hold significant promise for the treatment of drug-resistant breast cancer." 03/01/2014 - "More interestingly, when the media pH decreased from 7.4 to 5.5, the micelles shrank from 171.0 nm to 22.6 nm and their surface charge increased to 24.8 mV meanwhile, which resulted in the significantly improved cell uptake of CUR by human breast cancer MCF-7 cells. " 06/01/2010 - "Importantly, CPT-pH-PMs exhibited significantly increased therapeutic efficacy with minimum side effects by other tissues in breast tumor-bearing mice, compared to free CPT and CPT encapsulated PEG-PLLA micelles. " 11/01/2014 - "The therapeutic efficacy and toxicity of PTX-loaded micelles were investigated using a syngeneic mouse model of breast cancer (4T1.2). " 01/21/2015 - "Therefore, PEOz-hyd-DOX conjugate-based micelles might be potential drug delivery vehicles of DOX for safe and effective breast cancer therapy. "
3.	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 08/15/2015 - "This study aimed to prepare efficient cRGDyK peptide-decorated micelles for the targeted therapy of non-small-cell lung cancer (NSCLC). " 12/01/2010 - "Synergistic antitumor activity of the SN-38-incorporating polymeric micelles NK012 with S-1 in a mouse model of non-small cell lung cancer." 07/06/2006 - "Moreover, DOX-loaded micelles could slowly and efficiency decrease cell viability of non-small-cell lung carcinoma CL3 cells. " 04/07/2014 - "For the in vivo test, the therapeutic efficacy of the CPT-loaded micelles was studied in a non-small-cell lung cancer xenograft animal model. " 01/01/2012 - "The purpose of this study is to evaluate the efficacy of composite doxorubicinloaded micelles for enhancing doxorubicin radiosensitivity in multicellular spheroids from a non-small cell lung cancer cell line. "
4.	Carcinoma (Carcinomatosis) 10/01/2010 - "Moreover, the cellular uptake study demonstrated that the introduction of GA to the micelles could significantly increase the affinity for human hepatic carcinoma 7703 cells, which induced a 3.7-fold higher endocytosis than unmodified ones. " 07/13/2015 - "The resulting micelles had hydrodynamic diameters of around 30 nm. In this work, we show that fucosylated micelles reveal an increased uptake by pancreatic, lung, and ovarian carcinoma cell lines, whereas the uptake by the healthy cell lines (CHO) is negligible. " 01/01/2015 - "Both free Cur and Cur micelles efficiently suppressed growth of CT26 colon carcinoma cells in vitro. " 01/01/2015 - "The IC50 values of CUR-loaded micelles and free drug in human breast carcinoma cell lines were 4.10 μg/ml and 6.93 µg/ml, respectively. " 05/15/2014 - "In vitro cytotoxicity assay revealed that polymeric micelles loaded with PTX isomer had higher cytotoxic effect to normal human dermal fibroblasts (NHDF) and human colon carcinoma cells (HCT-116) than the same micelles loaded with non-isomerized PTX. "
5.	Experimental Arthritis 06/01/2013 - "Additionally, a pharmacodynamic study in vivo based on both the carrageenan-induced acute and complete Freund's adjuvant-induced adjuvant arthritis models indicated that sustained therapeutic efficacy could be achieved through subcutaneous injection of IND-loaded micelles. " 09/15/2008 - "In vivo pharmacodynamic study based on both carrageenan-induced acute and complete Freund's adjuvant (CFA) induced adjuvant-arthritis models indicated that sustained therapeutic efficacy could be achieved through intraarticular injection of IND-loaded micelles. " 12/01/2006 - "In vivo pharmacodynamic study based on both carrageenan-induced acute and complete Freund's adjuvant-induced adjuvant arthritis model indicated that sustained therapeutic efficacy could be achieved through intraarticular injection of IND-loaded micelles. "

Related Drugs and Biologics

1.	Paclitaxel (Taxol)
2.	Doxorubicin (Adriamycin)
3.	Carbon Monoxide
4.	Curcumin
5.	docetaxel (Taxotere)
6.	Folic Acid (Vitamin M)
7.	alpha-tocopheryl polyethylene glycol succinate
8.	Small Interfering RNA (siRNA)
9.	Polymers
10.	Ethylene Glycol (Monoethylene Glycol)

Related Therapies and Procedures

1.	Heterologous Transplantation (Xenotransplantation)
2.	Drug Therapy (Chemotherapy)
3.	Therapeutics
4.	Photochemotherapy (Photodynamic Therapy)
5.	Intra-Articular Injections