Abstract | OBJECTIVE: METHODS: RESULTS:
Olanzapine treatments for 1, 8 and 36 days significantly activated the inflammatory IKKβ/NFκB signaling, and increased the expression of TNF-α, IL-6, IL-1β and immune-related proteins such as iNOS, TLR4 and CD14. Olanzapine treatment for 1 day, 8 and 36 days also induced ER stress in the PFC. Co-treatment with an ER stress inhibitor, 4-phenylbutyrate, inhibited olanzapine-induced inflammation and the immune response in the PFC. CONCLUSION:
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Authors | Wen-Ting Li, Xu-Feng Huang, Chao Deng, Bao-Hua Zhang, Kun Qian, Meng He, Tao-Lei Sun |
Journal | Current medical science
(Curr Med Sci)
Vol. 41
Issue 4
Pg. 788-802
(Aug 2021)
ISSN: 2523-899X [Electronic] China |
PMID | 34403105
(Publication Type: Journal Article)
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Copyright | © 2021. Huazhong University of Science and Technology. |
Chemical References |
- Interleukin-1beta
- Interleukin-6
- Tlr2 protein, rat
- Toll-Like Receptor 2
- Nitric Oxide Synthase Type II
- Nos2 protein, rat
- I-kappa B Kinase
- Olanzapine
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Topics |
- Animals
- Apoptosis
(drug effects)
- Disease Models, Animal
- Endoplasmic Reticulum Stress
(drug effects, genetics)
- Gene Expression Regulation
(drug effects)
- Humans
- I-kappa B Kinase
(genetics)
- Immunity
(drug effects, genetics)
- Inflammation
(chemically induced, genetics, metabolism, pathology)
- Interleukin-1beta
(genetics)
- Interleukin-6
(genetics)
- Nitric Oxide Synthase Type II
(genetics)
- Olanzapine
(pharmacology)
- Oxidative Stress
(drug effects)
- Prefrontal Cortex
(drug effects, metabolism, pathology)
- Rats
- Schizophrenia
(complications, drug therapy, genetics, pathology)
- Signal Transduction
(drug effects)
- Toll-Like Receptor 2
(genetics)
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