Overview of key molecular and pharmacological targets for diabetes and associated diseases.

Abstract

Diabetes epidemiological quantities are demonstrating one of the most important communities' health worries. The essential diabetic difficulties are including cardiomyopathy, nephropathy, inflammation, and retinopathy. Despite developments in glucose decreasing treatments and drugs, these diabetic complications are still ineffectively reversed or prohibited. Several signaling and molecular pathways are vital targets in the new therapies of diabetes. This review assesses the newest researches about the key molecules and signaling pathways as targets of molecular pharmacology in diabetes and diseases related to it for better treatment based on molecular sciences. The disease is not cured by current pharmacological strategies for type 2 diabetes. While several drug combinations are accessible that can efficiently modulate glycemia and mitigate long-term complications, these agents do not reverse pathogenesis, and in practice, they are not established to modify the patient's specific molecular profiling. Therapeutic companies have benefited from human genetics. Genome exploration, which is agnostic to the information that exists, has revealed tens of loci that impact glycemic modulation. The physiological report has begun to examine subtypes of diseases, illustrate heterogeneity and propose biochemical therapeutic pathways.

• Authors: Seyed Hossein Shahcheraghi, Alaa A A Aljabali, Mazhar S Al Zoubi, Vijay Mishra, Nitin B Charbe, Yusuf A Haggag, Garima Shrivastava, Abdulmajeed G Almutary, Abdullah M Alnuqaydan, Debmalya Barh, Kamal Dua, Dinesh K Chellappan, Gaurav Gupta, Marzieh Lotfi, Ángel Serrano-Aroca, Bojlul Bahar, Yogendra Kumar Mishra, Kazuo Takayama, Pritam Kumar Panda, Hamid A Bakshi, Murtaza M Tambuwala
• Journal: Life sciences (Life Sci) Vol. 278 Pg. 119632 (Aug 01 2021) ISSN: 1879-0631 [Electronic] Netherlands
• PMID: 34019900 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2021 Elsevier Inc. All rights reserved.

Chemical References

• Hypoglycemic Agents

Topics

• Animals
• Diabetes Complications (drug therapy, genetics, metabolism, pathology)
• Diabetes Mellitus (drug therapy, genetics, metabolism, pathology)
• Drug Discovery
• Humans
• Hypoglycemic Agents (pharmacology, therapeutic use)
• Molecular Targeted Therapy
• Signal Transduction (drug effects)