Abstract | BACKGROUND: METHODS: RESULTS: Treatment with vitamin D3 increased serum 25OHD and upregulated VDR in lung tissues with or without hyperoxia. In addition, treatment with vitamin D3 attenuated alveolar simplification, increased VEGF and VEGFR2, and protected alveolar simplification induced by hyperoxia. Furthermore, treatment with vitamin D3 resulted in a decrease of IL-1β and IFN-γ and an increase of HIF-1α in lung tissues under hyperoxia conditions. CONCLUSION:
|
Authors | Yuchun Wang, Lian Jiang |
Journal | Pediatric pulmonology
(Pediatr Pulmonol)
Vol. 56
Issue 7
Pg. 2335-2344
(07 2021)
ISSN: 1099-0496 [Electronic] United States |
PMID | 33878208
(Publication Type: Journal Article)
|
Copyright | © 2021 Wiley Periodicals LLC. |
Chemical References |
- Receptors, Calcitriol
- Vascular Endothelial Growth Factor A
- Vitamin D
|
Topics |
- Animals
- Animals, Newborn
- Bronchopulmonary Dysplasia
(drug therapy, etiology)
- Humans
- Hyperoxia
(complications)
- Infant, Newborn
- Lung
- Rats
- Receptors, Calcitriol
(genetics)
- Vascular Endothelial Growth Factor A
- Vitamin D
|