Cholecalciferol (Vitamin D3)

Derivative of 7-dehydroxycholesterol formed by ULTRAVIOLET RAYS breaking of the C9-C10 bond. It differs from ERGOCALCIFEROL in having a single bond between C22 and C23 and lacking a methyl group at C24.

Also Known As:

Networked: 2502 relevant articles (201 outcomes, 412 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Holick, Michael F: 19 articles (08/2015 - 11/2003)
2.	Bostick, Roberd M: 15 articles (10/2015 - 03/2009)
3.	Chen, Tai C: 12 articles (12/2015 - 11/2003)
4.	Tangpricha, Vin: 9 articles (11/2015 - 10/2007)
5.	Vieth, Reinhold: 9 articles (05/2015 - 01/2005)
6.	Flanders, W Dana: 9 articles (04/2015 - 03/2009)
7.	Uskokovic, Milan: 9 articles (01/2013 - 11/2002)
8.	Shaukat, Aasma: 8 articles (10/2015 - 03/2009)
9.	Hayes, Colleen E: 8 articles (09/2015 - 09/2005)
10.	Long, Qi: 8 articles (04/2015 - 03/2009)

Related Diseases

1.	Psoriasis (Pustulosis Palmaris et Plantaris) 01/01/1996 - "Both treatments are effective in psoriasis, although several reports suggest that vitamin D3 is less effective in reducing the inflammatory changes compared to its potent effect on keratinocyte growth and differentiation. " 08/01/2008 - "In recent years, vitamin D3 analogs and a new formulation containing 8% clobetasol-17-propionate in a colourless nail lacquer vehicle have produced good results for the control of nail psoriasis. " 07/01/1991 - "Vitamin D3 analogs appear to provide one more promising treatment option for psoriasis." 10/01/2006 - "The findings of this retrospective observational study indicated that combination treatment with topical vitamin D(3) derivatives and narrow-band UVB is effective against psoriasis without any obvious side-effects. " 05/01/1989 - "Several open studies with active forms of vitamin D3 have been reported to be effective in the treatment of psoriasis. "
2.	Neoplasms (Cancer) 10/01/2010 - "Vitamin D(3) upregulated protein 1 (VDUP1) is a candidate tumor suppressor, the expression of which is dramatically reduced in various tumor tissues. " 01/01/2015 - "While complete resection of responsible tumors improved biochemical abnormalities in patients with TIO, treatment with phosphate and/or active vitamin D3 did not normalize serum phosphate and tubular maximum transport of phosphate in patients with XLH. " 10/06/2010 - "Fish oil in combination with vitamin D(3) resulted in a significant reduction in incidence, multiplicity and volume of mammary tumors. " 07/12/1996 - "Treating mice having established tumors and high levels of suppressor activity with vitamin D3 eliminated suppressor activity, increased anti-tumor immunity, induced an immune stimulatory cell population, and reduced tumor growth. " 07/01/2010 - "However, in in vivo models vitamin D3 was not found to be effective against tumor cell growth."
3.	Osteoporosis 10/05/2001 - "These results indicate that a chronopharmacological approach is beneficial for establishing a more effective and/or safer regimen of active vitamin D3 for the treatment of osteoporosis." 10/01/2004 - "For management of osteoporosis, the efficacy of vitamin D(3) and bisphosphonate had been demonstrated by meta-analytic approach. " 04/01/2009 - "The results of this study confirm the validity of vitamin D(3) to treat senile osteoporosis and suggest the need of higher vitamin D(3) intake in senile osteoporotic patients than in younger subjects." 01/01/2005 - "The role of vitamin D3 in osteoporosis is conclusively established from a very simple meta-analysis of the four randomized, placebo-controlled clinical trials into the effect of 20 microg (800 IU) per day. " 08/01/2004 - "Animal studies and clinical trials involving humans with data on therapy to treat or prevent glucocorticoid-induced osteoporosis with active vitamin D3 analogues were included. "
4.	Vitamin D Deficiency 09/01/2012 - "Full body NB-UVB three times per week is more effective in treating vitamin D deficiency than prescription of a daily oral intake of 1600 IU (40 μg) vitamin D(3) ." 10/01/2015 - "The aim of this study was to investigate the effects of vitamin D3 treatment on serum sclerostin levels in young adult females with severe vitamin D deficiency. " 06/01/2015 - "This study aimed to evaluate the effect of vitamin D3 megadose supplementation and influence of BsmI polymorphism in the VDR gene on the inflammatory profile and oxidative stress in elderly women with vitamin D deficiency. " 01/01/2015 - "The study involved 16 CKD stages 2-3 patients with vitamin D deficiency treated with cholecalciferol 7000-14000 IU/week for 6 months. " 10/15/2014 - "For the severe vitamin D deficiency subgroup analysis (n = 200), length of hospital stay was not significantly different between the 2 study groups: 20.1 days (IQR, 12.9-39.1) for vitamin D3 vs 19.0 days (IQR, 11.6-33.8) for placebo. "
5.	Rickets (Rachitis) 01/01/1980 - "It is concluded that high intermittent oral doses of vitamin D3 give an effective protection against rickets but at the cost of several times higher 25-OH-D concentration in serum and at the risk of hypervitaminosis D in some healthy infants." 02/01/2010 - "An IM injection of a mega dose of cholecalciferol is a safe and effective therapy for treatment of VDD rickets in infants and toddlers with normalization of all the biochemical parameters and healing of radiological manifestations. " 09/01/1984 - "Parenteral cholecalciferol is a safe and effective therapy for the treatment and prevention of childhood rickets." 09/01/1984 - "The safety and efficacy of parenteral cholecalciferol was evaluated in the treatment and prevention of childhood rickets. " 10/01/2005 - "An overall evaluation of the study indicates that chicks from hens fed the highest levels of vitamin D3 and fed high levels of Ca or 25-OHD3 had the highest BWG, tibia ash, and plasma Ca, and the lowest incidences of TD and Ca rickets."

Related Drugs and Biologics

1.	hydroxide ion
2.	Vitamin D
3.	Calcitriol (Calcijex)
4.	Calcium
5.	Cholecalciferol (Vitamin D3)
6.	25-hydroxyvitamin D
7.	calcipotriene (calcipotriol)
8.	Parathyroid Hormone (Parathormone)
9.	maxacalcitol
10.	Retinoids

Related Therapies and Procedures

1.	Renal Dialysis (Hemodialysis)
2.	Phototherapy (Light Therapy)
3.	Injections
4.	Heterologous Transplantation (Xenotransplantation)
5.	Intramuscular Injections