Abstract | OBJECTIVES: MATERIAL AND METHODS: RESULTS: The mice model had decreased performance in MWM, representing impairment of cognitive functions. Biochemical evaluation showed rise in TBARS level, MPO and AChE activity, and fall in GSH level. The histopathological study revealed severe infiltration of neutrophils. In the study, Phlorizin/ Donepezil (serving as positive control) treatment mitigate streptozotocin induced cognitive decline, histopathological changes and biochemical alterations. CONCLUSIONS: The results suggest that Phlorizin decreased cognitive function via its anticholinesterase, antioxidative, antiinflammatory effects and probably through SGLT inhibitory action. It can be conferred that SGLTs can be an encouraging target for the treatment of dementia of AD.
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Authors | Reena Rani, Amit Kumar, Amteshwar Singh Jaggi, Nirmal Singh |
Journal | Journal of basic and clinical physiology and pharmacology
(J Basic Clin Physiol Pharmacol)
Vol. 32
Issue 6
Pg. 1057-1064
(Feb 08 2021)
ISSN: 2191-0286 [Electronic] Germany |
PMID | 33548170
(Publication Type: Journal Article)
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Copyright | © 2021 Walter de Gruyter GmbH, Berlin/Boston. |
Chemical References |
- Symporters
- Streptozocin
- Sodium
- Phlorhizin
- Acetylcholinesterase
- Glucose
|
Topics |
- Acetylcholinesterase
(metabolism)
- Alzheimer Disease
(chemically induced, drug therapy)
- Animals
- Brain
(metabolism)
- Disease Models, Animal
- Glucose
(therapeutic use)
- Maze Learning
- Mice
- Oxidative Stress
- Phlorhizin
(adverse effects)
- Sodium
(adverse effects)
- Streptozocin
(pharmacology)
- Symporters
(adverse effects)
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