Abstract | BACKGROUND: Growing evidence shows that enhancer of zeste homolog 2 (EZH2) plays a role in various physiological functions and cancer pathogenesis. However, its contribution to allergic diseases remains controversial. We sought to investigate the role of EZH2 in the pathogenesis of allergic airway inflammation. METHODS: RESULTS: EZH2 expression was inhibited by DZNep treatment (P < 0.05). The administration of DZNep significantly inhibited the inflammatory cell infiltration (P < 0.0001) and goblet cell hyperplasia (P < 0.001). Moreover, it suppressed the secretion of IL-4 (P < 0.0001) and IL-6 (P < 0.01) in the BALF. CONCLUSIONS:
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Authors | Hang Li, Jian Li, Tong Lu, Dehua Chen, Rui Xu, Wei Sun, Xi Luo, Huabin Li, Renqiang Ma, Weiping Wen |
Journal | Molecular immunology
(Mol Immunol)
Vol. 131
Pg. 60-67
(03 2021)
ISSN: 1872-9142 [Electronic] England |
PMID | 33358566
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2020 Elsevier Ltd. All rights reserved. |
Chemical References |
- Anti-Inflammatory Agents
- Cytokines
- 3-deazaneplanocin
- Ovalbumin
- Adenosine
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Topics |
- Adenosine
(analogs & derivatives, pharmacology)
- Animals
- Anti-Inflammatory Agents
(pharmacology)
- Asthma
(chemically induced, drug therapy, metabolism)
- Bronchoalveolar Lavage Fluid
- Cytokines
(metabolism)
- Disease Models, Animal
- Female
- Hypersensitivity
(drug therapy, metabolism)
- Inflammation
(chemically induced, drug therapy, metabolism)
- Lung
(drug effects, metabolism)
- Mice
- Mice, Inbred BALB C
- Ovalbumin
(pharmacology)
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