Klotho Levels are Decreased and Associated with Enhanced Oxidative Stress and Inflammation in the Aqueous Humor in Patients with Exudative Age-related Macular Degeneration.

Abstract

PURPOSE:

To evaluate anti-aging protein klotho levels in the aqueous humor and its association with oxidative stress and inflammation in patients with age-related macular degeneration (AMD).

METHODS:

Levels of klotho, oxidative, and antioxidative stress markers, and proinflammatory and anti-inflammatory markers in the aqueous humor from 28 patients with exudative AMD and 35 age-matched controls were measured.

RESULTS:

Patients with AMD had lower levels of klotho, which were negatively correlated with macular lesion size. Patients with AMD also exhibited increased levels of 8-hydroxy-2'-deoxyguanosine (8-OHdG) and interleukin (IL)-6 but not tumor necrosis factor‑α, and decreased levels of total antioxidant status (TAS) and IL-10. Moreover, levels of klotho were negatively correlated with levels of 8-OHdG and IL-6, but positively correlated with levels of TSA and IL-10.

CONCLUSION:

Klotho levels in the aqueous humor are decreased and associated with oxidative stress and inflammation in patients with exudative AMD.

• Authors: Zhongxu Ma, Jingjing Liu, Jing Li, Hao Jiang, Jun Kong
• Journal: Ocular immunology and inflammation (Ocul Immunol Inflamm) Vol. 30 Issue 3 Pg. 630-637 (Apr 03 2022) ISSN: 1744-5078 [Electronic] England
• PMID: 33048602 (Publication Type: Journal Article)

Chemical References

• Cytokines
• Interleukin-6
• Interleukin-10

Topics

• Aqueous Humor (metabolism)
• Cytokines (metabolism)
• Humans
• Inflammation (metabolism)
• Interleukin-10 (metabolism)
• Interleukin-6 (metabolism)
• Macular Degeneration (diagnosis)
• Oxidative Stress