Abstract | OBJECTIVE: METHODS: RESULTS: SARS-CoV-2 RNA was detected in the plasma of 2 patients (cycle threshold [Ct] value 35.0-37.0) and in CSF at low levels (Ct 37.2, 38.0, 39.0) in 3 patients in 1 but not in a second real-time PCR assay. CSF neopterin (median 43.0 nmol/L) and β2-microglobulin (median 3.1 mg/L) were increased in all. Median immunoglobulin G index (0.39), albumin ratio (5.35), and CSF white blood cell count (<3 cells/µL) were normal in all, while CSF NfL was elevated in 2 patients. CONCLUSION:
|
Authors | Arvid Edén, Nelly Kanberg, Johanna Gostner, Dietmar Fuchs, Lars Hagberg, Lars-Magnus Andersson, Magnus Lindh, Richard W Price, Henrik Zetterberg, Magnus Gisslén |
Journal | Neurology
(Neurology)
Vol. 96
Issue 2
Pg. e294-e300
(01 12 2021)
ISSN: 1526-632X [Electronic] United States |
PMID | 33004602
(Publication Type: Case Reports, Journal Article)
|
Copyright | © 2020 American Academy of Neurology. |
Chemical References |
|
Topics |
- Adult
- Aged
- Aged, 80 and over
- Biomarkers
(cerebrospinal fluid)
- Blood-Brain Barrier
(diagnostic imaging, metabolism)
- COVID-19
(cerebrospinal fluid, complications, diagnostic imaging)
- Female
- Humans
- Male
- Middle Aged
- Nervous System Diseases
(cerebrospinal fluid, diagnostic imaging, etiology)
- SARS-CoV-2
(isolation & purification)
|