Abstract | ETHNOPHARMACOLOGICAL RELEVANCE: AIM OF THE STUDY: METHODS: RESULTS: The purity of swertiamarin was confirmed by HPLC. The results showed that CSQ was found to possess high percentage of inhibition in an in vitro α- amylase inhibitory study. In a STZ-induced type 2 diabetes mellitus (T2DM), body weight of rats in CSQ treated and control groups were unaltered. A marked reduction in the blood glucose levels was observed in the CSQ treated groups on 14th and 28th day. Decrease in the levels of low-density lipoprotein ( LDL), triglycerides, total cholesterol and an increase in high-density lipoprotein ( HDL) cholesterol level was observed in a dose dependant in CSQ treated groups. However, CSQ treated groups could significantly improve antioxidant protection by increasing the levels of serum GSH, SOD, Catalase and GPx and decreasing the levels of lipid peroxide (p < 0.05). In the histopathological study, the pancreatic islets of Langerhans and vacuolization have shown significant increase in both the treated groups. CONCLUSIONS:
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Authors | V Jaishree, Shravan Narsimha |
Journal | Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
(Biomed Pharmacother)
Vol. 130
Pg. 110561
(Oct 2020)
ISSN: 1950-6007 [Electronic] France |
PMID | 32795923
(Publication Type: Journal Article)
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Copyright | Copyright © 2020. Published by Elsevier Masson SAS. |
Chemical References |
- Blood Glucose
- Hypoglycemic Agents
- Iridoid Glucosides
- Lipids
- Pyrones
- swertiamarin
- Quercetin
- alpha-Amylases
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Topics |
- Animals
- Blood Glucose
(analysis)
- Body Weight
(drug effects)
- Diabetes Mellitus, Experimental
(complications, drug therapy)
- Diabetes Mellitus, Type 2
(complications, drug therapy)
- Ethnopharmacology
- Hyperglycemia
(drug therapy, etiology)
- Hyperlipidemias
(drug therapy, etiology)
- Hypoglycemic Agents
(therapeutic use)
- Iridoid Glucosides
(therapeutic use)
- Lipids
(blood)
- Male
- Oxidative Stress
(drug effects)
- Pyrones
(therapeutic use)
- Quercetin
(therapeutic use)
- Rats
- Rats, Wistar
- alpha-Amylases
(antagonists & inhibitors)
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