Lipid Peroxides

Peroxides produced in the presence of a free radical by the oxidation of unsaturated fatty acids in the cell in the presence of molecular oxygen. The formation of lipid peroxides results in the destruction of the original lipid leading to the loss of integrity of the membranes. They therefore cause a variety of toxic effects in vivo and their formation is considered a pathological process in biological systems. Their formation can be inhibited by antioxidants, such as vitamin E, structural separation or low oxygen tension.

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Networked: 1000 relevant articles (25 outcomes, 106 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Celik, Hakim: 6 articles (05/2014 - 04/2007)
2.	Das, Undurti N: 6 articles (01/2014 - 01/2007)
3.	Harangi, Mariann: 6 articles (10/2011 - 04/2002)
4.	Aksoy, Nurten: 5 articles (11/2014 - 01/2008)
5.	Erel, Ozcan: 5 articles (05/2014 - 03/2007)
6.	Aslan, Mehmet: 5 articles (07/2012 - 03/2007)
7.	Devaki, Thiruvengadam: 5 articles (01/2012 - 06/2006)
8.	Paragh, György: 5 articles (10/2011 - 04/2002)
9.	Das, U N: 5 articles (02/2006 - 09/2000)
10.	Lankin, V Z: 5 articles (07/2005 - 10/2000)

Related Diseases

1.	Ischemia 02/01/1997 - "Lipid peroxides are generated by the fetal rat brain after episodes of global ischemia in utero." 05/01/1993 - "Tissue levels of lipid peroxides (LPO) after 3 h ischemia and 1 h reperfusion did not change significantly compared with the nonischemic levels (0.71 +/- 0.32 nmol/mg protein, mean +/- SD). " 03/01/1992 - "In the liver ischemia-reperfusion model, levels of serum GOT, GPT and LDH activities and lipid peroxides in the liver tissue were significantly increased. " 06/01/1991 - "The level of lipid peroxides in liver tissue increased during 90-min ischemia. " 05/01/1991 - "Discriminant analysis further indicated that TBA-RS levels differentiate patients with and without vascular accidents, suggesting that high blood values of lipid peroxides could represent a predictive sign of vascular ischemia."
2.	Myocardial Infarction 07/01/1999 - "The initial level of lipid peroxides in beta-LP is 2-2.5-fold increased in myocardial infarction patients in comparison with healthy controls (p < 0.05), while oxidation resistance of beta-LP is decreased, the greatest decrease being observed during the 4th week of myocardial infarction (p < 0.05). " 02/01/1992 - "In the case of diabetic animals there was a decrease in the levels of lipid peroxides in the heart while in the case of diabetes associated with myocardial infarction it was slightly elevated. " 04/19/1987 - "[Lipid peroxides and other lipid metabolism parameters in the serum of children of parents with a past history of myocardial infarct]." 01/01/2010 - "Administration of 2Cl-SPZ or SPZ prior to ischemia significantly reduced myocardial infarct size, myocardial lipid peroxides, and ROS levels. " 05/01/2002 - "To determine whether the increased lipid hydroperoxide was related to bypass or reflected ongoing atherosclerosis, plasma lipid hydroperoxide was measured in acute myocardial infarction (AMI) and stable angina. "
3.	Atherosclerosis 02/01/1997 - "The present study indicates that hypercholesterolemic subjects have a high level of circulating lipid peroxides and that a higher tendency towards atherosclerosis in these subjects may be related to increased baseline levels of serum lipid peroxides." 12/01/2004 - "The epidemiology of plasma lipid peroxides, which may play a role in atherogenesis, has not been well defined. " 01/12/1998 - "In contrast, the relationship of total serum or plasma lipid peroxides (which also have a marked atherogenic action) with both aging and atherogenesis are not well understood. " 01/12/1998 - "Increase with age of serum lipid peroxides: implications for the prevention of atherosclerosis." 08/01/1997 - "Remnant-like particles (RLP) are reportedly involved in the pathogenesis of atherosclerosis, as are lipid peroxides. "
4.	Coronary Artery Disease (Coronary Atherosclerosis) 03/25/2008 - "This study was designed to determine the predictive value of lipid hydroperoxide (LOOH) levels for adverse cardiovascular outcomes in patients with stable coronary artery disease (CAD). " 11/01/1999 - "Lipid peroxides and antioxidant status in serum of patients with angiographically defined coronary atherosclerosis." 04/01/1993 - "Lipid peroxides and antioxidant defenses in accelerated transplantation-associated coronary arteriosclerosis." 10/15/1992 - "Lipid peroxides in plasma were similar in subgroups of patients with coronary artery disease without a history of myocardial infarct and those who had had myocardial infarct. " 10/15/1992 - "Lipid peroxides in plasma were determined in 100 patients with coronary artery disease, in 100 patients with peripheral artery disease and in 100 persons without any clinical symptoms of coronary or peripheral artery disease. "
5.	Granuloma 01/01/2008 - "fermentum ME-3 and ofloxacin eradicated Salmonella Typhimurium from blood, ileum and liver, decreased the number of animals with liver and spleen granulomas and reduced the value of lipid peroxides in the ileum mucosa. " 04/01/1997 - "The paw volume, biochemical parameters like tissue AST, ALT, gamma-GTP and lipid peroxides and dry wt. of granuloma were measured to assess the anti-inflammatory activity. " 04/01/1987 - "Further, these drugs were found to inhibit the levels of lipid peroxides, acid phosphatase, and gamma-glutamyl transpeptidase activity in the exudate of cotton pellet granuloma. " 01/01/1992 - "The lung extracts prepared from mice with hypersensitivity lung granulomas, but not foreign body lesions, contained high levels of superoxide dismutase (SOD) and thiobarbiturate-reactive substances including lipid peroxides. " 02/01/2008 - "In cotton pellet induced granuloma, MEBM at the same doses was found to significantly inhibit granuloma tissue formation, including significant reduction in levels of serum lysosomal enzymes (SGOT, SGPT and ALP) and lipid peroxides as compared to control."

Related Drugs and Biologics

1.	Free Radicals
2.	Antioxidants
3.	alpha-Tocopherol
4.	Enzymes
5.	Lipoproteins (Lipoprotein)
6.	Cholesterol
7.	Isoproterenol (Isoprenaline)
8.	Oxygen
9.	LDL Cholesterol
10.	Messenger RNA (mRNA)

Related Therapies and Procedures

1.	Ligation
2.	Aftercare (After-Treatment)
3.	Intravenous Injections
4.	Renal Dialysis (Hemodialysis)
5.	Rewarming