The myocardial protective effect of monosodium phosphate cardioplegia in cardiopulmonary bypass in infants with an atrial septal defect.

Abstract

This study aimed to investigate the myocardial protective effect of liquid sodium phosphocreatine cardiac arrest in extracorporeal circulation surgery treating infants with atrial septal defects.Eighty-four infants with atrial septal defects who required extracorporeal circulation surgery treatment at our hospital from January 2016 to June 2018 were divided into an observation group and a control group through a digitally randomized method, with 42 cases in each group. The control group adopted the conventional modified St Thomas II high potassium cold liquid crystal cardiac arrest, while the observation group adopted the liquid sodium phosphocreatine cardiac arrest.The myocardial enzyme indexes of the 2 groups 3, 6, 12, and 24 hours postoperatively were higher than before establishing the cardiopulmonary bypass and the enzyme indexes of the control group at the same time were higher than that of the observation group; adenosine triphosphate, adenosine diphosphate, and other energy levels and the postoperative recovery rate energy levels of the observation group were higher than those in the control group, the difference was statistically significant (P < .05).Liquid sodium phosphocreatine cardiac arrest used in extracorporeal circulation surgery treating infants with atrial septal defects can reduce myocardial ischemia-reperfusion injury, maintain energy supply during ischemia, strengthen the St Thomas II effect, and aid postoperative cardiac function recovery of high potassium cold liquid crystal cardiac arrest used in infants with atrial septal defects and treated with extracorporeal circulation surgery.

• Authors: Fang Yang, Jie Wang, Bo Zhai
• Journal: Medicine (Medicine (Baltimore)) Vol. 99 Issue 28 Pg. e20934 (Jul 10 2020) ISSN: 1536-5964 [Electronic] United States
• PMID: 32664090 (Publication Type: Journal Article, Observational Study)

Chemical References

• Cardiotonic Agents
• Protective Agents
• Phosphocreatine
• Adenosine Diphosphate
• Potassium Chloride
• Adenosine Triphosphate

Topics

• Adenosine Diphosphate (metabolism)
• Adenosine Triphosphate (metabolism)
• Cardiopulmonary Bypass (methods)
• Cardiotonic Agents (administration & dosage, pharmacology)
• Case-Control Studies
• Child, Preschool
• Extracorporeal Circulation (methods)
• Female
• Heart Arrest (chemically induced)
• Heart Arrest, Induced (methods)
• Heart Septal Defects, Atrial (diagnosis, drug therapy, surgery)
• Humans
• Infant
• Male
• Myocardial Reperfusion Injury (prevention & control)
• Myocardium (chemistry, enzymology)
• Organ Preservation (methods)
• Phosphocreatine (administration & dosage, pharmacology)
• Postoperative Period
• Potassium Chloride (administration & dosage, pharmacology)
• Protective Agents (administration & dosage)
• Recovery of Function (drug effects)