Abstract | BACKGROUND: METHODS: Matched sputum and serum, obtained from 62 stable COPD patients and 14 age-matched controls, were assayed for the presence of IgG and IgM antibodies against 13 autoantigens using protein array. A sputum eosinophil count ≥3% was used as cut-off value to stratify COPD patients into eosinophilic and non-eosinophilic groups. Correlation network analysis was used to evaluate the correlation patterns among autoantibody and clinical variables in each group. RESULTS: There were no significant differences of clinical parameters and autoantibody levels between the two COPD groups. In non-eosinophilic COPD, sputum anti-CytochromeC_ IgG and anti- Aggrecan_ IgM were significantly higher than those in healthy controls, and prior exacerbation was positively associated with lung function and sputum anti- Collagen-IV_ IgG. While in eosinophilic COPD, sputum/serum anti- heat shock protein (HSP)47_ IgG, serum anti-HSP70_ IgG and serum anti- Amyloid-beta_ IgG were significantly lower than those in healthy controls, and no significant correlation between prior exacerbations and lung function was found. Differences were also observed in network hubs, with the network for non-eosinophilic COPD possessing 9 hubs comprising two lung function parameters and seven autoantibodies, compared with eosinophilic COPD possessing 12 hubs all comprising autoantibodies. CONCLUSIONS:
Autoantibody responses were heterogeneous and differentially correlated with the exacerbation risk and other clinical parameters in COPD patients of different inflammatory phenotypes. These findings provide useful insight into the need for personalized management for preventing COPD exacerbations.
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Authors | Zhenyu Liang, Fengyan Wang, Dongying Zhang, Fei Long, Yuqiong Yang, Weili Gu, Kuimiao Deng, Jiaxuan Xu, Wenhua Jian, Luqian Zhou, Weijuan Shi, Jinping Zheng, Xin Chen, Rongchang Chen |
Journal | Journal of thoracic disease
(J Thorac Dis)
Vol. 12
Issue 6
Pg. 3085-3100
(Jun 2020)
ISSN: 2072-1439 [Print] China |
PMID | 32642231
(Publication Type: Journal Article)
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Copyright | 2020 Journal of Thoracic Disease. All rights reserved. |