Galectin-3 is a potential biomarker to insulin resistance and obesity in women with polycystic ovary syndrome.

Abstract

Polycystic ovary syndrome (PCOS) is the most common endocrine and metabolic disorder that affects women in reproductive age. This study aimed to evaluate Gal-3 levels and its role on metabolic parameters in women with PCOS. Gal-3 was measured in 44 PCOS and 25 women recruited as control group for the case-control study. Gal-3 levels were similar between PCOS and control groups (p > 0.05), but showed a positive correlation with glucose levels in the oral glucose tolerance test (OGTT) (r = 0.403, p = 0.037), body mass index (BMI) (r = 0.469, p = 0.027), insulin levels (r = 0.453, p = 0.030) and HOMA-IR (r = 0.738, p = 0.037) in PCOS group. The data suggest that Gal-3 plays a role in the pathophysiology of the insulin resistance and obesity in PCOS group.

• Authors: Michelle T Alves, Isabella D P de Souza, Cláudia N Ferreira, Ana Lúcia Cândido, Mariana F Bizzi, Flávia R Oliveira, Fernando M Reis, Karina B Gomes
• Journal: Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology (Gynecol Endocrinol) Vol. 36 Issue 9 Pg. 760-763 (Sep 2020) ISSN: 1473-0766 [Electronic] England
• PMID: 32157924 (Publication Type: Journal Article)

Chemical References

• Biomarkers
• Blood Proteins
• Galectins
• LGALS3 protein, human

Topics

• Adult
• Biomarkers (blood)
• Blood Proteins
• Body Mass Index
• Case-Control Studies
• Female
• Galectins (blood)
• Glucose Tolerance Test
• Humans
• Insulin Resistance (physiology)
• Obesity (blood, complications, diagnosis)
• Polycystic Ovary Syndrome (blood, complications, diagnosis)