Abstract | INTRODUCTION:
Parkinson's disease (PD) is a multisystem disorder of unknown etiology, highlights a broad array of symptoms and pathological features influencing organs throughout the body. The metabolic profile of saliva in patients with PD may be influenced by malabsorption in the gastroenteric tract, neurodegeneration, and mitochondrial dysfunction. In the present study, we apply a powerful NMR metabolomics approach for biomarker identification in PD using saliva, a non-invasive bio-fluid. METHODS: RESULTS: Increased concentration of phenylalanine, tyrosine, histidine, glycine, acetoacetate, taurine, TMAO, GABA, N-acetylglutamate, acetoin, acetate, alanine, fucose, propionate, isoleucine, and valine were observed in PD as compared to HC. Further, subgroup analysis among early PD, advanced PD, and HC groups, revealed increased metabolite concentration in early PD group as compared to advanced PD and HC group. DISCUSSION: Analysis revealed potential biomarkers and their involvement in amino acid metabolism, energy metabolism, neurotransmitters metabolism, and microflora system. Patients with early PD exhibited higher metabolite concentration as compared to advanced PD group which might be associated with dopaminergic treatment. CONCLUSION: The results of our data indicate that patients with PD might be characterized by metabolic imbalances like gut microflora system, energy metabolites, and neurotransmitters which may contribute to the PD pathogenesis.
|
Authors | Sadhana Kumari, Vinay Goyal, S Senthil Kumaran, S N Dwivedi, Achal Srivastava, N R Jagannathan |
Journal | Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
(Neurol Sci)
Vol. 41
Issue 5
Pg. 1201-1210
(May 2020)
ISSN: 1590-3478 [Electronic] Italy |
PMID | 31897951
(Publication Type: Journal Article)
|
Chemical References |
|
Topics |
- Adult
- Aged
- Biomarkers
(metabolism)
- Female
- Humans
- Male
- Metabolomics
- Middle Aged
- Parkinson Disease
(diagnosis, metabolism)
- Proton Magnetic Resonance Spectroscopy
- Saliva
(metabolism)
- Sensitivity and Specificity
|