Fucose

12/01/2015 - "This study investigates the dose-specific pro-oxidative behavior of a bacterial fucose polysaccharide, which attenuated proliferation of different cancer cells. "
04/01/1993 - "The aim of the study was to determine whether there is neo-expression of alpha-L-fucose in the normal appearing mucosa of the distal bowel in subjects with or at risk of hereditary bowel cancer. "
05/01/1980 - "The effect of smoking on L-fucose levels may account for discrepancies in L-fucose data reported in previous studies of mammary cancer. "
01/01/2015 - "Major N-glycan branching structures which are directly related to cancer are β1,6-GlcNAc branching, bisecting GlcNAc, and core fucose. "
03/01/2013 - "The presence of the MM12 peak, related to the fucose II complex, in tumors harboring a K-ras gene mutation has been investigated. "

01/01/2015 - "Notably, human rotaviruses DS-1 (P[4]) and RV-3 (P[6]) also use A-type HBGAs for infection, with fucose involvement. "
03/01/1968 - "Selective effects of L-fucose on BHK21 hamster fibroblasts and on BHK21 cells transformed by infections with polyoma virus."
06/15/2015 - "New work suggests that fucose can have a protective role in both gut-centered and systemic infection and inflammation. "
03/01/2010 - "In conclusion, in LAD II, the main clinical countenance shifts from frequent infections due to immunodeficiency in the early years to the metabolic consequences of the defect in fucose metabolism, i.e., retarded growth and mental retardation, in the later years. "
08/01/1997 - "This shows that the delta F508 CF mutation observed in this patient does not affect ciliary beating and suggests that treatment with fucose in the early stages of a Pseudomonas aeruginosa infection could be advantageous for cystic fibrosis patients."

02/01/1998 - "The FG region was expressed in yeast and lacked the fucose on Thr61, which was reported to be important for efficient clearance of t-PA by human hepatoma cells. "
01/01/1984 - "The data presented show specific alterations of fucose and fucoprotein metabolism which could be considered as a characteristic feature of chicken viral-induced hepatoma Mc-29."
01/01/1984 - "It was found that the labelling of hepatoma tissue homogenate and plasma membranes was higher than that of the same liver preparations 3 hr after the [14C]fucose injection. "
05/01/1977 - "Our results indicate that specific alterations of fucose metabolism are a characteristic feature of Morris hepatomas."
11/03/1995 - "A recombinant finger/growth factor construct inhibited t-PA and t-PA/plasminogen activator inhibitor type-1 degradation with an IC50 of 1800 nM, whereas a t-PA mutant lacking the finger and growth factor domains inhibited degradation with an estimated IC50 of 1200 nM. In comparison the IC50 of t-PA was found to be approximately 10 nM. Clearance of t-PA by human or rat hepatoma cells was not inhibited by high concentrations of fucose (50 mM), which suggests that the fucose on Thr-61 is not involved in clearance by these cells. "

05/01/2007 - "All fucoidans inhibited leucocyte recruitment in an inflammation model in rats, and neither the content of fucose and sulfate nor other structural features of their polysaccharide backbones significantly affected the efficacy of fucoidans in this model. "
02/29/2012 - "Carbocisteine, a mucoregulatory drug, corrects the contents of fucose in airway mucus and has anti-inflammatory properties in airway inflammation. "
05/01/2009 - "AGP with elevated fucose content isolated from patients with untreated chronic joint inflammation showed a decreased [Ca(2+)](i) modulatory effect on neutrophils compared to normally fucosylated AGP. "
10/27/2004 - "Both natural and fucose-depleted hAGP protect against renal I/R injury by preservation of tubular epithelial structure and inhibition of apoptosis and subsequent inflammation. "
06/15/2015 - "New work suggests that fucose can have a protective role in both gut-centered and systemic infection and inflammation. "

01/01/2012 - "Targeting anticancer drug delivery to pancreatic cancer cells using a fucose-bound nanoparticle approach."
04/01/2011 - "In this work, we study interactions between DC and the oncofetal fucose-rich glycovariants of bile salt-dependent lipase (BSDL), expressed in pancreatic cancer tissues and referred to as pathological BSDL carrying the fucosylated J28 glycotope (pBSDL-J28) because it is characterized by the mAb J28. "
06/05/2015 - "The fucose post-translational modification is frequently increased in pancreatic cancer, thus forming the basis for promising biomarkers, but a subset of pancreatic cancer patients does not elevate the known fucose-containing biomarkers. "
10/01/2013 - "There was a clear increase in overall expression of serum glycans, especially highly-branched glycans with fucose moieties, in pancreatic cancer. "
01/01/2012 - "These enzymes accelerate malignant transformation through fucosylation of sialylated precursors, suggesting a crucial requirement for fucose by pancreatic cancer cells. "