Abstract | AIM: METHODS: RESULTS: We found that α- mangostin inhibited RORγt transcription activity in a cell-based assay and also polarized Th17 cells in an in vitro induction experiment. Our results also showed that α- mangostin could significantly decrease serum anti-dsDNA antibody levels, IL-17A and IFN-γ expression and alleviate renal pathological damage in the α- mangostin-treated group mice than in the model group mice. CONCLUSION: Thus, α- mangostin demonstrated its potential as a candidate therapeutic drug for LN and other Th17-mediated autoimmune diseases by inhibiting the function of Th17.
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Authors | Xiaoqing Zhou, Huanpeng Chen, Fengjiao Wei, Qingyu Zhao, Qiao Su, Yu Lei, Meng Yin, Xuyan Tian, Zhonghua Liu, Bolan Yu, Chuan Bai, Xixin He, Zhaofeng Huang |
Journal | International journal of rheumatic diseases
(Int J Rheum Dis)
Vol. 23
Issue 1
Pg. 74-83
(Jan 2020)
ISSN: 1756-185X [Electronic] England |
PMID | 31769201
(Publication Type: Journal Article)
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Copyright | © 2019 Asia Pacific League of Associations for Rheumatology and John Wiley & Sons Australia, Ltd. |
Chemical References |
- Terpenes
- Xanthones
- pristane
- mangostin
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Topics |
- Animals
- Cell Differentiation
(drug effects)
- Disease Models, Animal
- Female
- Immunity, Cellular
(drug effects)
- Lupus Nephritis
(chemically induced, immunology, metabolism)
- Mice
- Mice, Inbred BALB C
- Mice, Inbred C57BL
- Terpenes
(toxicity)
- Th17 Cells
(immunology, pathology)
- Xanthones
(pharmacology)
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