Macroprolactinaemia modulates cardiometabolic effects of fenofibrate in men with atherogenic dyslipidaemia: A pilot study.

Abstract

WHAT IS KNOWN AND OBJECTIVE:

Cardiometabolic effects of hypolipidaemic agents depend on plasma levels of monomeric prolactin. Although macroprolactinaemia seems to be associated with increased cardiometabolic risk, no previous study has investigated whether macroprolactinaemia modulates pleiotropic effects of hypolipidaemic agents.

METHODS:

The study population included two age-, weight-, blood pressure- and lipid-matched groups of men: 12 men with elevated levels of big-big prolactin and 16 men with prolactin levels within the reference range. Because of atherogenic dyslipidaemia, all subjects were treated for 6 months with fenofibrate (200 mg daily). Glucose homeostasis markers and plasma lipids, as well as plasma levels of uric acid, high-sensitivity C-reactive protein (hsCRP), fibrinogen, homocysteine and 25-hydroxyvitamin D, were determined in patients at the beginning and at the end of the study.

RESULTS AND DISCUSSION:

Men with elevated levels of big-big prolactin were characterized by higher levels of hsCRP and fibrinogen and lower levels of 25-hydroxyvitamin D as well as decreased insulin sensitivity than subjects with prolactin levels within the reference range. In men without macroprolactinaemia, fenofibrate decreased circulating levels of total and LDL cholesterol, triglycerides, uric acid, hsCRP and fibrinogen, and increased concentrations of HDL cholesterol, homocysteine and 25-hydroxyvitamin D, as well as improved insulin sensitivity. In subjects with macroprolactinaemia, fenofibrate action was limited to the changes in HDL cholesterol, triglycerides, hsCRP and homocysteine. With the exception of homocysteine, cardiometabolic effects of fenofibrate were stronger in subjects without than in subjects with elevated levels of big-big prolactin.

WHAT IS NEW AND CONCLUSION:

The results of the study indicate that macroprolactinaemia exerts a negative impact on cardiometabolic effects of fenofibrate.

• Authors: Robert Krysiak, Karolina Kowalcze, Bogusław Okopień
• Journal: Journal of clinical pharmacy and therapeutics (J Clin Pharm Ther) Vol. 45 Issue 1 Pg. 115-121 (Feb 2020) ISSN: 1365-2710 [Electronic] England
• PMID: 31444987 (Publication Type: Journal Article)
• Copyright: © 2019 John Wiley & Sons Ltd.

Chemical References

• Hypolipidemic Agents
• Lipids
• prolactin, polymeric
• Vitamin D
• Prolactin
• 25-hydroxyvitamin D
• Fenofibrate

Topics

• Adult
• Atherosclerosis (drug therapy, etiology)
• Case-Control Studies
• Dyslipidemias (complications, drug therapy)
• Fenofibrate (administration & dosage, pharmacology)
• Humans
• Hypolipidemic Agents (administration & dosage, pharmacology)
• Lipids (blood)
• Male
• Middle Aged
• Pilot Projects
• Prolactin (blood)
• Vitamin D (analogs & derivatives, blood)