Abstract | BACKGROUND: METHODS: RESULTS: The authors demonstrated 1Y expression in the spinal cord dorsal horn. Morphine administration evoked a calcium response (mean ± SD) (57 ± 13 nM) in cells coexpressing both gastrin releasing peptide receptor and the 1Y isomer. This was blocked by 10 μM naltrexone (0.7 ± 0.4 nM; P < 0.0001), 1 μM gastrin-releasing peptide receptor antagonist (3 ± 2 nM; P < 0.0001), or 200 μM 1Y-peptide (2 + 2 nM; P < 0.0001). In mice, 0.4 nmol 1Y-peptide significantly attenuated morphine-induced scratching behaviors (scratching bouts, vehicle vs. 1Y- peptide) (92 ± 31 vs. 38 ± 29; P = 0.011; n = 6 to 7 mice per group), without affecting morphine antinociception in warm water tail immersion test (% of maximum possible effect) (70 ± 21 vs. 67 ± 22; P = 0.80; n = 6 mice per group). CONCLUSIONS:
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Authors | Xian-Yu Liu, Yehuda Ginosar, Joseph Yazdi, Alexander Hincker, Zhou-Feng Chen |
Journal | Anesthesiology
(Anesthesiology)
Vol. 131
Issue 2
Pg. 381-391
(08 2019)
ISSN: 1528-1175 [Electronic] United States |
PMID | 31314749
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
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Chemical References |
- Analgesics, Opioid
- Narcotic Antagonists
- Receptors, Bombesin
- Receptors, Opioid, mu
- Naltrexone
- Morphine
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Topics |
- Aged
- Analgesics, Opioid
(adverse effects)
- Animals
- Behavior, Animal
- Cadaver
- Disease Models, Animal
- Humans
- Male
- Mice
- Mice, Inbred C57BL
- Morphine
(adverse effects)
- Naltrexone
(administration & dosage)
- Narcotic Antagonists
(administration & dosage)
- Pruritus
(chemically induced, prevention & control)
- Receptors, Bombesin
(drug effects)
- Receptors, Opioid, mu
(drug effects)
- Spinal Cord
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