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Naltrexone (ReVia)

Derivative of noroxymorphone that is the N-cyclopropylmethyl congener of NALOXONE. It is a narcotic antagonist that is effective orally, longer lasting and more potent than naloxone, and has been proposed for the treatment of heroin addiction. The FDA has approved naltrexone for the treatment of alcohol dependence.

Also Known As:

ReVia; Antaxone; Bristol-Myers Squibb Brand of Naltrexone Hydrochloride; Celupan; Du Pont Brand of Naltrexone Hydrochloride; EN-1639A; Lacer Brand of Naltrexone Hydrochloride; Lamepro Brand of Naltrexone Hydrochloride; Nalorex; Naltrexone Hydrochloride; Nemexin; Orphan Brand of Naltrexone Hydrochloride; Pharmazam Brand of Naltrexone Hydrochloride; Schering-Plough Brand of Naltrexone Hydrochloride; Trexan; United Drug Brand of Naltrexone Hydrochloride; Bristol Myers Squibb Brand of Naltrexone Hydrochloride; EN 1639A; EN1639A; Hydrochloride, Naltrexone; Schering Plough Brand of Naltrexone Hydrochloride; Morphinan-6-one, 17-(cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxy-, (5alpha)-

Networked: 1331 relevant articles (169 outcomes, 255 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Zagon, Ian S: 20 articles (10/2015 - 04/2003)
2.	McLaughlin, Patricia J: 18 articles (10/2015 - 04/2003)
3.	Dehpour, Ahmad Reza: 15 articles (01/2015 - 08/2002)
4.	O'Malley, Stephanie S: 15 articles (10/2014 - 02/2002)
5.	Hulse, Gary K: 11 articles (06/2014 - 09/2003)
6.	Grant, Jon E: 11 articles (02/2014 - 04/2002)
7.	O'Brien, Charles P: 11 articles (08/2013 - 11/2002)
8.	Dehpour, Ahmad R: 10 articles (05/2014 - 12/2006)
9.	Kim, Suck Won: 10 articles (02/2014 - 04/2002)
10.	Sullivan, Maria A: 9 articles (04/2015 - 12/2002)

Related Diseases

1.	Alcoholism (Alcohol Abuse) 03/01/2003 - "As research continues on the optimal use of naltrexone for modifying alcohol intake, a number of factors have emerged that are likely to determine the efficacy of naltrexone as a pharmacotherapeutic agent for the treatment of alcoholism. " 01/01/2003 - "Although many physicians and others treating alcoholism have found naltrexone to be very helpful in treatment, it is still a technology that has not been used widely. " 01/01/1998 - "The majority indicated that it helped them understand "a good deal" about the management of alcoholism and the use of network therapy and naltrexone. " 01/01/2003 - "As studies continue on the use of naltrexone for modifying alcohol intake, promising avenues for continued work on maximizing the efficacy of naltrexone for treating alcohol abuse and alcoholism are emerging. " 09/01/1999 - "Clinical studies have shown that the opioid antagonist naltrexone is effective in the treatment of alcoholism. "
2.	Pruritus (Itching) 06/01/2007 - "In the open study more than 70% of the patients using the 1% naltrexone cream experienced a significant reduction of pruritus. " 10/20/1999 - "Effective treatment of pruritus with naltrexone, an orally active opiate antagonist." 01/01/2004 - "Two recent studies have provided opposite results on the efficacy of naltrexone on uremic pruritus. " 10/01/2005 - "After multiple treatment failures, her itching was relieved with naltrexone. " 12/07/1996 - "Our data suggest short-term efficacy with few side-effects for the amelioration of uraemic pruritus with naltrexone."
3.	Pain (Aches) 02/01/2013 - "When contrasting the condition end points, we observed a significantly greater reduction of baseline pain in those taking low-dose naltrexone than in those taking placebo (28.8% reduction versus 18.0% reduction; P = 0.016). " 06/01/2013 - "Reduction of conditioned pain modulation in humans by naltrexone: an exploratory study of the effects of pain catastrophizing." 02/01/2013 - "In this replication and extension study of a previous clinical trial, we tested the impact of low-dose naltrexone on daily self-reported pain. " 12/01/2009 - "In this study, we test the extent to which analgesic effects of acute anger arousal on subsequent pain sensitivity are opioid mediated by subjecting healthy participants to anger-induction and pain either under opioid blockade (oral naltrexone) or placebo. " 03/01/2004 - "This study was conducted to compare adrenocortical, pain sensitivity, and blood pressure responses to opioid blockade using naltrexone in men and women. "
4.	Opioid-Related Disorders (Opiate Addiction) 01/01/2014 - "Ultra-rapid opioid detoxification (UROD) and subsequently induction of naltrexone maintenance therapy can be regarded as a safe and effective detoxification method for use in patients with opiate addiction. " 06/01/2010 - "UROD and subsequently induction of naltrexone maintenance therapy can be regarded as safe and effective in patients with pure opiate addiction. " 03/01/1984 - "The results suggest that naltrexone is not a "cure" for opiate dependence, but is a medication which can be useful in protecting patients from re-addiction and is a modality patients should be encouraged to return to if they feel vulnerable to re-addiction." 01/01/1988 - "A number of studies have established the clinical efficacy of naltrexone in the treatment of opiate addiction. " 10/01/2009 - "There is increasing interest in the use of implantable naltrexone as a new treatment for opiate dependence. "
5.	Obesity 04/01/1999 - "Naltrexone in primary hyperphagic obesity wity hypochondriacal disorder - a clinical study." 11/01/2014 - "Opposing neural effects of naltrexone on food reward and aversion: implications for the treatment of obesity." 08/01/2009 - "Naltrexone for the treatment of obesity: review and update." 04/01/2007 - "Conditioned place preferences (CPPs) to high-caloric "snack foods" in rat strains genetically prone vs. resistant to diet-induced obesity: resistance to naltrexone blockade." 04/01/1999 - "RMANOVA revealed no statically significant (p>0.05) decrease in body mass index suggesting that psychoeducational methods with naltrexone were as ineffective in reducing obesity as psychoeducational methods alone. "

Related Drugs and Biologics

1.	Opioid Receptors (Opioid Receptor)
2.	Naltrexone (ReVia)
3.	Morphine (MS Contin)
4.	Naloxone (Narcan)
5.	Bupropion (Wellbutrin)
6.	acamprosate (AOTA)
7.	Opioid Analgesics (Opioids)
8.	Fluoxetine (Prozac)
9.	Ethanol (Ethyl Alcohol)
10.	naltrexone combination morphine

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Injections
3.	Analgesia
4.	Therapeutics
5.	Anesthesia