Abstract | INTRODUCTION: The aim of this study was to evaluate the inflammatory profile of T helper (Th) cells in normoglycemic (N) and diabetic rats with apical periodontitis (AP). METHODS: RESULTS: The DM group showed more intense inflammatory infiltrate with larger sizes of bone reabsorption and a greater presence of bacteria than the N group (P < .05). Proinflammatory cytokine levels in the DM group were also greater than those in the N group (P < .05). However, interferon gamma was more intense in the N group than in the DM group (P < .05). CONCLUSIONS: The inflammatory profile of AP in DM is different from that in the N group, suggesting that Th1 is a secondary strain and the Th17 strain is predominant in DM.
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Authors | Renata Oliveira Samuel, Edilson Ervolino, Índia Olinta de Azevedo Queiroz, Mariane Maffei Azuma, Gabriela Tiago Ferreira, Luciano Tavares Angelo Cintra |
Journal | Journal of endodontics
(J Endod)
Vol. 45
Issue 8
Pg. 1009-1015
(Aug 2019)
ISSN: 1878-3554 [Electronic] United States |
PMID | 31227229
(Publication Type: Journal Article)
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Copyright | Copyright © 2019 American Association of Endodontists. Published by Elsevier Inc. All rights reserved. |
Topics |
- Animals
- Diabetes Mellitus, Experimental
- Humans
- Inflammation
- Male
- Periapical Periodontitis
(metabolism)
- Rats
- Rats, Wistar
- T-Lymphocytes, Regulatory
- Th1 Cells
- Th17 Cells
- Th2 Cells
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