Abstract | OBJECTIVE: MATERIALS AND METHODS: In this experimental study, adult female Wistar rats were randomly divided into five groups. Rats received an intraperitoneal injection of minocycline immediately after SCI, and then 24 hours after the injury. Transplantations were performed 7 days after the injury. Functional recovery was evaluated using the Basso, Beattie and Bresnahan scale (BBB). After that, the animals were sacrificed, and T11 segment of the spinal cord was removed after 5 weeks, and then used for histopathological, immunohistochemical, and biochemical assessments. Western blot analysis was applied to determine the protein expression of tumor necrosis factor alpha (TNF-α), interleukin 1 beta (IL1β) and caspase3. RESULTS: CONCLUSION: The combinatory treatment with OECs graft and minocycline induced a more effective response to the repair of spinal cord injury, and it is considered a therapeutic potential for the treatment of SCI.
|
Authors | Soheila Pourkhodadad, S Hahrbanoo Oryan, Gholamreza Kaka, Seyed Homayoon Sadraie |
Journal | Cell journal
(Cell J)
Vol. 21
Issue 2
Pg. 220-228
(Jul 2019)
ISSN: 2228-5806 [Print] Iran |
PMID | 30825296
(Publication Type: Journal Article)
|
Copyright | Copyright© by Royan Institute. All rights reserved. |