Abstract | BACKGROUND: METHODS: RESULTS: CONCLUSIONS: HLA alleles can be used as prognostic biomarkers for immunologic disorders of platelet such as ITP, TTP, and HIT. Different DRB1 alleles enable the assessment of resistance to common ITP treatments as well as disease prognosis. Due to the genetic association between HLA-DR1 and HLA-DQ1 alleles and the role of HLA-DRB1 *11 in TTP, the HLA-DQB1 *02: 02 allele may also play a role in TTP pathogenesis.
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Authors | Ali Amin Asnafi, Mohammad Taha Jalali, Seyed Mohammad Sadegh Pezeshki, Kaveh Jaseb, Najmaldin Saki |
Journal | Journal of pediatric hematology/oncology
(J Pediatr Hematol Oncol)
Vol. 41
Issue 2
Pg. 81-86
(03 2019)
ISSN: 1536-3678 [Electronic] United States |
PMID | 30543580
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
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Chemical References |
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Topics |
- HLA Antigens
(blood, immunology)
- Hemorrhage
(blood, immunology, pathology)
- Heparin
(adverse effects)
- Humans
- Platelet Count
- Purpura, Thrombocytopenic, Idiopathic
(blood, immunology, pathology)
- Purpura, Thrombotic Thrombocytopenic
(blood, immunology, pathology)
- Thrombocytopenia
(blood, chemically induced, immunology, pathology)
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