HLA Antigens (Human Leukocyte Antigens)

Antigens determined by leukocyte loci found on chromosome 6, the major histocompatibility loci in humans. They are polypeptides or glycoproteins found on most nucleated cells and platelets, determine tissue types for transplantation, and are associated with certain diseases.

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Networked: 2336 relevant articles (23 outcomes, 268 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Yilmaz, Erkan: 6 articles (08/2013 - 03/2002)
2.	Pospelov, L E: 5 articles (01/2008 - 01/2002)
3.	Konenkov, V I: 5 articles (01/2006 - 05/2000)
4.	Papasteriades, C A: 4 articles (07/2004 - 04/2000)
5.	Tarassi, K E: 4 articles (07/2004 - 04/2000)
6.	Gaudieri, Silvana: 3 articles (01/2016 - 10/2009)
7.	Reichert, Stefan: 3 articles (01/2015 - 03/2008)
8.	Amoroso, Antonio: 3 articles (01/2015 - 03/2006)
9.	Aida, Y: 3 articles (01/2015 - 02/2007)
10.	Maio, Michele: 3 articles (06/2014 - 09/2003)

Related Diseases

1.	Infection 08/01/2008 - "The hepatitis C virus (HCV) infection course and efficacy of treatment may be depended on HLA antigens. " 08/01/2005 - "It is suggested that vaginal or rectal exposure to allogeneic stimulation by a partner's HLA antigens in seminal fluid, as occurs during sexual intercourse, or immunization by semi-allogeneic fetuses in multiparous females may elicit protection against SIV or human immunodeficiency virus infection." 01/01/2015 - "Although human leukocyte antigens (HLA) have been shown in association with the outcomes of hepatitis C virus (HCV) infection among different ethnic groups, such studies remain absent in China, where the HCV prevalence is higher than the global average. " 09/01/2008 - "The aim of our work was to evaluate the infection rate among uraemic patients, and study the relationship between HLA antigens and H. " 07/01/2014 - "Multiple major histocompatibility complex (MHC) loci encoding human leukocyte antigens (HLA) have allelic variants unequivocally associated with differential immune control of HIV-1 infection. "
2.	Rheumatoid Arthritis 08/12/1993 - "These findings suggest that the maternal immune response to paternal HLA antigens may have a role in the pregnancy-induced remission of rheumatoid arthritis." 02/01/1986 - "Twenty-five patients with rheumatoid arthritis (RA) who developed toxicity while taking remission inducing drugs and 30 without toxicity were studied for possible associations with class I and II HLA antigens. " 06/01/1991 - "Rheumatoid arthritis (RA) is known to be associated with class II HLA antigens in most populations, but recent studies in Israeli Jewish patients showed no significant differences in either DR4 or DR1 between patients and controls. " 01/01/1987 - "HLA antigens and adult rheumatoid arthritis: a study with a monoclonal antibody." 04/01/1984 - "Study of HLA antigens in ten multiple-case rheumatoid arthritis families."
3.	Neoplasms (Cancer) 12/02/2010 - "This approach demonstrates the efficacy of using "off-the-shelf," virus-specific third-party CTLs restricted by human leukocyte antigens expressed by the tumor to treat otherwise lethal EBV-PTLD. " 06/01/1988 - "In order to elucidate the mechanism by which HLA antigens expression is induced or enhanced on the injured or transformed hepatocytes, we have made in vitro studies using human hepatic tumor-derived cell lines as a model system. " 06/01/1986 - "Immunohistochemical study of HLA antigens and lymphocyte infiltration in melanocytic tumors." 06/01/1986 - "Our studies are consistent with the proposal that altered expression of HLA antigens on tumors might impair recognition of these cells by the immune system of the host, thereby contributing to the proliferation of a malignant clone." 07/01/1985 - "In our present study, we contemplated unraveling the relationship between HLA antigens and malignant bone and soft-tissue tumor. "
4.	Schizophrenia (Dementia Praecox) 01/01/1981 - "We found no convincing association of HLA-antigens and Schizophrenia with exception of a significant reduction of Aw19 in our study of 140 schizophrenic patients. " 07/01/2008 - "This preliminary observation may help to understand the etiological basis of this disorder and the study may further strengthen the HLA antigens as the marker for schizophrenia." 01/01/2005 - "The aim of this preliminary study was to investigate how individual class I and II HLA antigens in schizophrenic patients may be related to schizophrenia and to the intensity of two kinds of EMD: fixation and smooth pursuit. " 01/01/2005 - "Relationship between class I and II HLA antigens in schizophrenia and eye movement disturbances: a preliminary study." 08/20/1999 - "It has been proposed that there is an immune component in the aetiology of schizophrenia, and the distribution of human leukocyte antigens (HLA) in schizophrenic patients and controls has been investigated in numerous studies. "
5.	Inflammation 08/07/2002 - "Endothelial dysfunction of peripheral arteries in patients with immunohistologically confirmed myocardial inflammation correlates with endothelial expression of human leukocyte antigens and adhesion molecules in myocardial biopsies." 07/01/1997 - "Early, aggressive treatment is indicated in patients with significant joint inflammation and certain HLA antigens. " 03/01/1994 - "The inflammation-promoted expression of HLA antigens is of less importance for graft survival if the difference in the HLA antigens is reduced by the match." 05/01/2000 - "The above changes of blood cell cytomembranes and renal tissue can be used as diagnostic criteria of inflammation activity in pyelonephritis while the HLA antigens are helpful for detection of CP risk groups." 01/01/2015 - "The genotype and phenotype of human cytokines, innate immunity, and human leukocyte antigens are also associated with the onset of immune clearance of HBV and severity of inflammation. "

Related Drugs and Biologics

1.	Antigens
2.	Antibodies
3.	Cytokines
4.	Gold
5.	HLA-B27 Antigen (HLA B27 Antigen)
6.	HLA-B Antigens (HLA-B)
7.	HLA-B57
8.	Genetic Markers (Genetic Marker)
9.	HLA-A Antigens (HLA-A)
10.	Insulin (Novolin)

Related Therapies and Procedures

1.	Homologous Transplantation (Allograft)
2.	Immunotherapy
3.	Platelet Transfusion (Blood Platelet Transfusions)
4.	Blood Transfusion (Blood Transfusions)
5.	Tissue Transplantation