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Thrombotic Thrombocytopenic Purpura

An acquired, congenital, or familial disorder caused by PLATELET AGGREGATION with THROMBOSIS in terminal arterioles and capillaries. Clinical features include THROMBOCYTOPENIA; HEMOLYTIC ANEMIA; AZOTEMIA; FEVER; and thrombotic microangiopathy. The classical form also includes neurological symptoms and end-organ damage, such as RENAL FAILURE. Mutations in the ADAMTS13 PROTEIN gene have been identified in familial cases.
Also Known As:
Purpura, Thrombotic Thrombocytopenic; Congenital Thrombotic Thrombocytopenic Purpura; Familial Thrombotic Thrombocytopenia Purpura; Familial Thrombotic Thrombocytopenic Purpura; Microangiopathic Hemolytic Anemia, Congenital; Moschcowitz Disease; Schulman-Upshaw Syndrome; Thrombotic Microangiopathy, Familial; Upshaw Factor, Deficiency of; Upshaw-Schulman Syndrome; Familial Thrombotic Microangiopathy; Microangiopathy, Familial Thrombotic; Schulman Upshaw Syndrome; Thrombocytopenic Purpura, Thrombotic; Thrombopenic Purpura, Thrombotic; Thrombotic Thrombopenic Purpura; Upshaw Schulman Syndrome; Moschkowitz Disease; Purpura, Thrombotic Thrombopenic; Thrombotic Thrombocytopenic Purpura, Congenital; Thrombotic Thrombocytopenic Purpura, Familial
Networked: 3662 relevant articles (184 outcomes, 117 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Hemolytic-Uremic Syndrome
2. Thrombocytopenia (Thrombopenia)
3. Thrombotic Microangiopathies
4. Atypical Hemolytic Uremic Syndrome
5. Idiopathic Thrombocytopenic Purpura (Thrombocytopenic Purpura, Autoimmune)

Experts

1. Coppo, Paul: 75 articles (03/2022 - 05/2002)
2. George, James N: 73 articles (11/2022 - 01/2002)
3. Matsumoto, Masanori: 72 articles (08/2022 - 01/2002)
4. Veyradier, Agnès: 72 articles (01/2022 - 04/2002)
5. Fujimura, Yoshihiro: 55 articles (01/2019 - 01/2002)
6. Vanhoorelbeke, Karen: 48 articles (10/2022 - 03/2006)
7. Lämmle, Bernhard: 47 articles (02/2021 - 01/2002)
8. Kremer Hovinga, Johanna A: 43 articles (01/2022 - 08/2003)
9. Vesely, Sara K: 42 articles (10/2020 - 01/2003)
10. Scully, Marie: 41 articles (01/2022 - 10/2006)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Thrombotic Thrombocytopenic Purpura:
1. thiamine triphosphorate (TTP)IBA
2. Rituximab (Mabthera)FDA Link
3. Vincristine (Oncovin)FDA LinkGeneric
4. von Willebrand FactorIBA
5. caplacizumabIBA
6. SteroidsIBA
7. Adrenal Cortex Hormones (Corticosteroids)IBA
8. AntibodiesIBA
9. Platelet Aggregation Inhibitors (Antiplatelet Drugs)IBA
10. Intravenous Immunoglobulins (IVIG)FDA Link

Therapies and Procedures

1. Plasma Exchange
2. Therapeutics
3. Plasmapheresis
4. Splenectomy
5. Bone Marrow Transplantation (Transplantation, Bone Marrow)