Abstract | BACKGROUND:
Neurological disorders constitute a growing worldwide concern due to the progressive aging of the population and the risky behavior they represent. Herbal medicines have scientific relevance in the treatment of these pathologies. One of these substances, Astragaloside IV (AS-IV), is the main active compound present in the root of Astragalus membranaceus (Fisch.) Bge, a Chinese medicinal herb with neuroprotective properties. OBJECTIVE: METHODS: This study is a systematic review, where an electronic search in United States National Library of Medicine (PubMed), Science Direct, Cochrane Library, Scientific Electronic Library Online (SciELO), Scopus, Web of Science, Medline via Proquest and Periodicos Capes databases covering the years between 2007 and 2017, using " Astragaloside IV" and " Neurodegenerative diseases"; " Astragaloside IV" and " Neurological disorders" as reference terms was made. RESULTS: CONCLUSION: The findings of the present study indicate that the administration of AS-IV can improve behavioral and neurochemical deficits largely due to its antioxidant, antiapoptotic and antiinflammatory properties, emerging as an alternative therapeutic approach for the treatment of neurological disorders.
|
Authors | Ianara M Costa, Francisca O V Lima, Luciana C B Fernandes, Bianca Norrara, Francisca I Neta, Rodrigo D Alves, José R L P Cavalcanti, Eudes E S Lucena, Jeferson S Cavalcante, Amalia C M Rego, Irami A Filho, Dinalva B Queiroz, Marco A M Freire, Fausto P Guzen |
Journal | Current neuropharmacology
(Curr Neuropharmacol)
Vol. 17
Issue 7
Pg. 648-665
( 2019)
ISSN: 1875-6190 [Electronic] United Arab Emirates |
PMID | 30207235
(Publication Type: Journal Article, Meta-Analysis, Systematic Review)
|
Copyright | Copyright© Bentham Science Publishers; For any queries, please email at [email protected]. |
Chemical References |
- Neuroprotective Agents
- Saponins
- Triterpenes
- astragaloside A
|
Topics |
- Alzheimer Disease
- Animals
- Brain Ischemia
- Encephalomyelitis
- Humans
- Nervous System Diseases
(drug therapy)
- Neuroprotective Agents
(pharmacology)
- Parkinson Disease
- Saponins
(pharmacology)
- Triterpenes
(pharmacology)
|