Association between rs2275913 single-nucleotide polymorphism of the interleukin-17A gene and perioperative analgesic use in cosmetic orthognathic surgery.

Abstract

AIM:

Interleukin-17A (IL-17A) plays an essential role in tissue inflammation by inducing proinflammatory cytokine and chemokine production and is related to innate immune reactions. IL-17A also contributes to neuroinflammation, neuropathic pain, and mechanical hypersensitivity after peripheral nerve injury in rodents. To clarify the contribution of IL-17A to pain-related phenotypes in humans, we investigated the association between pain-related phenotypes and the rs2275913 single-nucleotide polymorphism (SNP) of the IL-17A gene, which has been reported to be associated with rheumatoid arthritis, ulcerative colitis, and some cancers.

METHODS:

The present study used a correlational design to examine the impact of the rs2275913 SNP on postoperative pain-related phenotypes in a group of patients who underwent cosmetic orthognathic surgery.

RESULTS:

Carriers of the AA genotype had higher opioid requirements during and after surgery than carriers of the AG and GG genotypes (P = .009). Linear regression analysis indicated that opioid requirements linearly increased as the copy number of the A allele of the SNP increased (P = .008).

CONCLUSIONS:

Opioid requirements during and after surgery are enhanced in carriers of the AA genotype of the rs2275913 SNP of the IL-17A gene, possibly through an enhancement of IL-17A function that induces inflammation that is related to the inflammatory pain stimulus.

• Authors: Seii Ohka, Daisuke Nishizawa, Junko Hasegawa, Kaori Takahashi, Kyoko Nakayama, Yuko Ebata, Ken-Ichi Fukuda, Kazutaka Ikeda
• Journal: Neuropsychopharmacology reports (Neuropsychopharmacol Rep) Vol. 38 Issue 2 Pg. 67-74 (06 2018) ISSN: 2574-173X [Electronic] United States
• PMID: 30106258 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2018 The Authors. Neuropsychopharmacology Reports published by John Wiley & Sons Australia, Ltd on behalf of The Japanese Society of Neuropsychopharmacology.

Chemical References

• Analgesics, Opioid
• Interleukin-17

Topics

• Adolescent
• Adult
• Analgesics, Opioid (therapeutic use)
• Female
• Humans
• Interleukin-17 (genetics)
• Male
• Middle Aged
• Orthognathic Surgical Procedures (adverse effects)
• Pain, Postoperative (drug therapy, genetics)
• Polymorphism, Single Nucleotide
• Surgery, Plastic (adverse effects)