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Effects of phenidone (DuCLOX-2/5 inhibitor) against N-methyl-N-nitrosourea induced mammary gland carcinoma in albino rats.

Abstract
The present study was designed to evaluate the effects of phenidone (Dual inhibitor of COX-2 and 5-LOX, DuCLOX-2/5 inhibitor) on various aspects of cancer chemoprevention. Treatment with the phenidone was inquested to validate the implications of dual inhibition of arachidonic acid (AA) metabolism against MNU induced mammary gland carcinogenesis. MNU treated rat showed altered hemodynamic profile, distorted cellular architecture, upregulated inflammatory enzyme markers (COX, LOX, Nitric oxide and hydrogen sulfide) and distorted oxidative stress markers (thiobarbituric acid reactive substances, protein carbonyl, superoxide dismutase, catalase and glutathione). Phenidone treatment regulated histological architecture in the experimental animals similar to control. The treatment with phenidone favorably regulated the levels of inflammatory markers, and oxidative stress markers against toxic treatment. Our findings emphasize the potential role of phenidone in suppression of mammary gland carcinoma against the deleterious effects of MNU.
AuthorsSwetlana Gautam, Soniya Rani, Sara A Aldossary, Abdulaziz S Saeedan, Mohd Nazam Ansari, Gaurav Kaithwas
JournalToxicology and applied pharmacology (Toxicol Appl Pharmacol) Vol. 351 Pg. 57-63 (07 15 2018) ISSN: 1096-0333 [Electronic] United States
PMID29679652 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2018 Elsevier Inc. All rights reserved.
Chemical References
  • Cyclooxygenase 2 Inhibitors
  • Lipoxygenase Inhibitors
  • Pyrazoles
  • Methylnitrosourea
  • Arachidonate 5-Lipoxygenase
  • ALOX5 protein, human
  • phenidone
Topics
  • Animals
  • Arachidonate 5-Lipoxygenase (metabolism)
  • Cyclooxygenase 2 Inhibitors (therapeutic use)
  • Female
  • Lipoxygenase Inhibitors (therapeutic use)
  • Mammary Neoplasms, Experimental (chemically induced, drug therapy, metabolism)
  • Methylnitrosourea (toxicity)
  • Pyrazoles (therapeutic use)
  • Random Allocation
  • Rats
  • Rats, Wistar
  • Treatment Outcome

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