Abstract | BACKGROUND: OBJECTIVE: MATERIALS AND METHODS: Paw withdrawal thresholds (PWTs) and paw withdrawal latencies (PWLs) were tested to examine the analgesic effect of ligustilide on CFA-induced inflammatory pain in rats. The change of spinal JNK/c-Jun activation was detected by western blotting after CFA injection with or without consecutive intrathecal ligustilide administration. After SP600125 (JNK inhibitor) was intrathecally injected in CFA rats, PWTs and PWLs were tested to investigate the change of ligustilide's analgesic effect. RESULTS: CONCLUSION:
Ligustilide could inhibit the upregulation of spinal p-JNK/p-c-Jun caused by CFA, and the inhibition of JNK/c-Jun activation is closely related to its anti- mechanical hyperalgesia effect in inflammatory pain. SUMMARY:
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Authors | Yi-Rui Wang, Hui Xu, Min Tao, Li-Hua Xu, Xin-Chun Fu |
Journal | Pharmacognosy magazine
(Pharmacogn Mag)
2017 Oct-Dec
Vol. 13
Issue 52
Pg. 634-638
ISSN: 0973-1296 [Print] India |
PMID | 29200725
(Publication Type: Journal Article)
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